Gene ID:HHVTW005
GenBank Locus Tag:
DNA Molecule Name:
1
GenBank ID:
330308
Gene Name:
UL3
Definition:
nuclear phosphoprotein, cellular homolog (HS2UL3A)
Cellular Location:
[Evidence]
Gene Start:
11033
Gene Stop:
11734
Gene Length:
702
Molecular Weight*:
25519
pI*:
10.50
Net Charge*:
9.77
EC:
Functional Class:
protein transport
Gene Ontology:
Pathway: pathway table
Primary Evidence:
Holzerlandt R, Orengo C, Kellam P, Alba MM.
Identification of new herpesvirus gene homologs in the human genome,
Genome Res. 2002 Nov;12(11):1739-48,
PMID: 12421761.
Yamada H, Jiang YM, Zhu HY, Inagaki-Ohara K, Nishiyama Y,
Nucleolar localization of the UL3 protein of herpes simplex virus type 2,
J Gen Virol 1999 Aug;80 ( Pt 8):2157-64,
Medline: 99394691.
Worrad,D.M. and Caradonna,S.,
The herpes simplex virus type 2 UL3 open reading frame encodes a nuclear localizing phosphoprotein,
Virology 195 (2), 364-376 (1993),
Medline: 93331693.
McGeoch,D.J., Cunningham,C., McIntyre,G. and Dolan,A.,
Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2,
J. Gen. Virol. 72 (Pt 12), 3057-3075 (1991),
Medline: 92113549.
Secondary Evidence:
Ghiasi H, Perng GC, Cai S, Nesburn AB, Wechsler SL,
The UL3 open reading frame of herpes simplex virus type 1 codes for a phosphoprotein,
Virus Res 1996 Oct;44(2):137-42,
Medline: 97033395.
Singh J, Wagner EK,
Transcriptional analysis of the herpes simplex virus type 1 region containing the TRL/UL junction,
Virology 1993 Sep;196(1):220-31,
Medline: 93362408.
McGeoch,D.J., Dalrymple,M.A., Davison,A.J., Dolan ,A., Frame,M.C., McNab,D., Perry,L.J., Scott,J.E. and Taylor,P.,
The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1,
J. Gen. Virol. 69 (Pt 7), 1531-1574 (1988),
Medline: 88274327.
Comment:
Worrad and Caradonna (1993) report that immunohistochemical analysis of infected cells reveals the UL3 protein has a perinuclear location early in infection and at later times becomes associated with the nucleus as discrete particles. They also suggest it is posttranslationally phosphorylated.
Holzerlandt et al.(2002) identify UL3 as a cellular homolog.
In HSV-1 UL3 is dispensable in cell culture, Baines and Roizzman (1991) and has gamma-2 expression regulation, Markovitz et al.(1999).
Blast Summary: PSI-Blast Search
Residues 1-230 of the UL3 protein are 75% similar using gapped BLAST to residues 1-232 of the UL3 protein in Human herpesvirus 1 (strain 17). UL3 has significant similarilty to Equine herpesvirus 1 & 4 (P28942 & AAC59579)51% (55%) over 211(208) aa, Gallid herpesvirus 2 (AAA61508), Bovine herpesvirus 1.1 (CAA06132), and many other Alphaherpesvirinae. Variants include P28279.
Top Blast Hits: Updated monthly
Click here to view the entire PsiBlast results.
COGS Summary: COGS Search
None.
Blocks Summary: Blocks Search
None.
ProDom Summary: Protein Domain Search
Residues 1-91 and 92-228 constitute phosphoprotein domains (PD021063 and PD006494) as seen in Q89644_VVVVV. Residues 38-103 are 37% similar to a domain (PD092220) seen in C.elegans O44596_CAEEL.
Paralogs: Local Blast Search
None.
Pfam Summary: Pfam Search
None.
Structural Feature(s):
| Feature Type | Start | Stop |
| non-globular |
Top PDB Hits:
None.
Gene Protein Sequence:
MVKSRVSYRSVMSGVGEERVPSAFTILASWGWTFAPQNHDPGASPNTTPI
ESIAGTAPDAHVGPLDGEPDRDAISPLTSSVAGDPPGADGPYVTFDTLFM
VSSIDELGRRQLTDTIRKDLRLSLAKFSIACTKTSSFSGTAARQRKRGAP
PQRTCVPRSNKSLQMFVLCKRANAAQVREQLRAVIRSRKPRKYYTRSSDG
RLCPAVPVFVHEFVSSEPMRLHRDNVMLSTEPD$
Gene Nucleotide Sequence: Sequence Viewer
ATGGTTAAATCTCGGGTCTCATACCGGTCCGTGATGTCGGGCGTGGGGGA
AGAGAGGGTCCCCTCTGCGTTTACTATCCTTGCCTCGTGGGGCTGGACGT
TTGCACCCCAGAACCATGATCCTGGCGCGTCGCCGAATACGACGCCCATA
GAGTCGATTGCGGGGACCGCACCGGACGCGCACGTGGGGCCTCTCGACGG
AGAGCCGGACCGGGATGCGATCTCCCCGCTTACGTCGAGCGTGGCCGGCG
ACCCGCCGGGGGCGGACGGCCCCTACGTCACCTTTGATACTCTGTTTATG
GTATCTTCGATCGACGAACTGGGGCGCCGCCAGCTCACGGATACGATCCG
TAAGGACCTGCGGCTGTCGCTGGCCAAGTTCAGCATCGCGTGTACCAAGA
CCTCGTCGTTTTCGGGGACGGCCGCGCGCCAGCGCAAGCGCGGAGCACCG
CCGCAACGCACATGCGTACCACGCAGCAACAAGAGCCTCCAGATGTTCGT
TTTGTGCAAGCGCGCCAACGCCGCGCAGGTGCGCGAGCAGCTGCGGGCGG
TTATTCGGTCGCGCAAGCCGCGCAAGTATTACACGCGGTCCTCGGATGGG
CGGCTCTGCCCGGCCGTCCCCGTGTTTGTACACGAGTTTGTTTCGTCCGA
ACCCATGCGCCTCCATCGAGATAACGTCATGCTGTCTACGGAACCAGACT
AA