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Human Herpesvirus 2 Search Results

Record: 1 of 1  
MiniMap IGR10 IGR11 IGR13 UL18, - HHVTW020 UL16, - HHVTW018 UL13, - HHVTW015 UL12, - HHVTW014 UL17, - HHVTW019 UL15, - HHVTW017 UL18, - HHVTW020 UL16, - HHVTW018 UL13, - HHVTW015 UL12, - HHVTW014 UL17, - HHVTW019 UL15, - HHVTW017 UL18, - HHVTW020 UL16, - HHVTW018 UL13, - HHVTW015 UL12, - HHVTW014 UL17, - HHVTW019 UL14, - HHVTW016 UL14, - HHVTW016 UL15, - HHVTW017 UL15.5, - HHVTW019.1 UL15.5, - HHVTW019.1


Gene ID:HHVTW018

GenBank Locus Tag:

DNA Molecule Name:
1  

GenBank ID:
1869838

Gene Name:
UL16  

Definition:
virion protein

Cellular Location:
[Evidence]

Gene Start:
31261

Gene Stop:
30143

Gene Length:
1119

Molecular Weight*:
40089

pI*:
7.60

Net Charge*:
3.90

EC:
 

Functional Class:
virion production; DNA cleavage  
virion production; DNA packaging  

Gene Ontology:

Pathway: pathway table

Primary Evidence:
Oshima S, Daikoku T, Shibata S, Yamada H, Goshima F, Nishiyama, Characterization of the UL16 gene product of herpes simplex virus type 2, Arch Virol 1998;143(5):863-80, Medline: 98309064.

Su YH, Oakes JE, Lausch RN, Mapping the genetic region coding for herpes simplex virus resistance to mouse interferon alpha/beta, J Gen Virol 1993 Nov;74 ( Pt 11):2325-32, Medline: 94065657.



Secondary Evidence:
Nalwanga D, Rempel S, Roizman B, Baines JD , The UL 16 gene product of herpes simplex virus 1 is a virion protein that colocalizes with intranuclear capsid proteins, Virology 1996 Dec 15;226(2):236-42, Medline: 97124648.

Baines JD, Roizman B, The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture, J Virol 1991 Feb;65(2):938-44, Medline: 91101305.

McGeoch,D.J., Dalrymple,M.A., Davison,A.J., Dolan,A., Frame,M.C.,, McNab,D., Perry,L.J., Scott,J.E. and Taylor,P., The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1, J. Gen. Virol. 69 (Pt 7), 1531-1574 (1988), Medline: 88274327.




Comment:
The UL16 gene is entirely coded within the intron of the UL15 gene and it's proposed start codon is CTG. UL16 belongs to a family that includes HSV-1 UL16, HSV-6 ORF11R, EHV-1 46, HCMV UL94, EBV BGLF2, HSV 33, and VZV 44.

In HSV-1 UL16 is dispensable in cell culture and has gamma expression regulation (Roizman, PNAS 93:11307,1996, Medline: 97030190).


Blast Summary:  PSI-Blast Search
Residues 1-370 of the UL16 protein are 75% similar using gapped BLAST to residues 1-371 of the UL16 protein in Human herpesvirus 1 (strain 17), 33% (31%) similar over 317 aa in Equine herpesvirus 1 (4) (gene 46), 29% similar over 304 aa in Bovine herpesvirus 1 (UL16) and less similar with other Alphaherpesvirinae.

Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|9629285|ref|NP_044485.1| proposed start codon is CTG [Human h...   781   0.0  
 gi|9629395|ref|NP_044617.1| UL16 [Human herpesvirus 1] >gnl|BL_O...   572   e-162
 gi|30984444|ref|NP_851875.1| UL16 [Cercopithecine herpesvirus 1]...   498   e-140
 gi|28804651|dbj|BAC58055.1| UL16 [Cercopithecine herpesvirus 1]       491   e-138
 gi|9626784|ref|NP_041056.1| ORF 46 [Equine herpesvirus 1] >gnl|B...   183   5e-45
 gi|9629773|ref|NP_045264.1| 46 [Equine herpesvirus 4] >gnl|BL_OR...   179   7e-44
 gi|9629860|ref|NP_045344.1| virion protein [Bovine herpesvirus 1...   178   2e-43
 gi|13242437|ref|NP_077459.1| unknown [Cercopithecine herpesvirus...   155   1e-36
 gi|10180720|gb|AAG14208.1|AF243438_23 UL16 tegument protein-like...   153   4e-36
 gi|10834885|ref|NP_066846.1| UL16 protein [Gallid herpesvirus 3]...   150   4e-35


COGS Summary:  COGS Search
None.

Blocks Summary:  Blocks Search
None.

ProDom Summary:  Protein Domain Search
Residues 33-371 constitute a UL16 domain as seen in P89439_VVVVV.

Paralogs:  Local Blast Search
None.

Pfam Summary:  Pfam Search
None.

Structural Feature(s):
Feature Type  Start  Stop
non-globular  
1  
273

Top PDB Hits:
None.

Gene Protein Sequence:
LAQRALWRPQATPGPPGAAAPPGHRGAPPDARAPDPGPEADLVARIANSV
FVWRVVRGDERLKIFRCLTVLTEPLCQVALPDPDPERALFCEIFLYLTRP
KALRLPSNTFFAIFFFNRERRYCATVHLRSVTHPRTPLLCTLAFGHLEAA
SPPEETPDPAAEQLADEPVAHELDGAYLVPTDTAPESGACCALGPGAWWH
LPGGRIYCWAMDDDLGSLCPPGSRARHLGWLLSRITDPPGGGGACAPTAH
IDSANALWRAPAVAEACPCVAPCMWSNMAQRTLAVRGDASLCQLLFGHPV
DAVILRQATRRPRITAHLHEVVVGRDGAESVIRPTSAGWRLCVLSSYTSR
LFATSCPAVARAVARASSSDYK$

Gene Nucleotide Sequence:  Sequence Viewer
CTGGCACAGCGGGCACTCTGGCGTCCCCAGGCGACGCCAGGCCCCCCGGG
AGCCGCGGCCCCGCCGGGTCACCGGGGCGCCCCCCCCGACGCGCGCGCCC
CCGACCCGGGGCCCGAAGCCGACCTCGTCGCGCGCATCGCCAACTCTGTC
TTCGTGTGGCGCGTCGTTCGGGGGGACGAGCGGCTTAAGATTTTTCGGTG
CCTCACGGTCCTCACCGAGCCGCTGTGCCAGGTGGCCCTTCCGGACCCCG
ACCCCGAGCGTGCCCTTTTCTGCGAGATCTTCCTGTACCTGACGCGGCCC
AAGGCGCTGCGCCTGCCTTCGAACACGTTCTTTGCCATTTTCTTCTTTAA
CCGCGAGCGCCGCTACTGCGCCACCGTCCACCTCCGCAGCGTAACGCACC
CCCGGACCCCGCTGCTGTGCACCCTAGCCTTCGGCCACCTGGAAGCTGCC
TCCCCCCCGGAGGAAACCCCCGACCCCGCCGCCGAACAGCTCGCGGACGA
GCCCGTGGCCCACGAGCTCGACGGCGCCTACCTGGTACCCACGGACACGG
CCCCCGAATCCGGGGCGTGCTGTGCCCTGGGTCCGGGGGCCTGGTGGCAC
CTCCCCGGCGGCCGCATATACTGCTGGGCCATGGATGATGACCTGGGGTC
GCTCTGTCCCCCGGGCAGCCGGGCCCGCCATTTAGGATGGCTGCTATCCA
GGATTACCGACCCCCCGGGAGGAGGCGGCGCCTGCGCCCCGACGGCCCAC
ATCGATTCCGCCAACGCGCTGTGGCGCGCCCCCGCCGTGGCGGAGGCCTG
TCCCTGCGTCGCCCCGTGCATGTGGTCCAATATGGCCCAGCGCACCCTGG
CCGTCCGGGGGGACGCGAGCCTGTGTCAGCTCCTCTTCGGGCACCCCGTG
GACGCGGTTATCCTGCGGCAGGCGACCCGCCGCCCGCGCATCACGGCCCA
CCTGCACGAGGTCGTCGTGGGCCGGGACGGCGCGGAAAGCGTCATCCGCC
CGACCAGCGCCGGGTGGCGCCTCTGCGTTCTGTCATCGTATACCAGCCGC
CTGTTTGCAACGAGCTGCCCCGCGGTCGCGCGGGCCGTGGCCAGAGCCTC
ATCGTCCGATTACAAATAA

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