Basic Search | Intermediate Search | Advanced Search | Gene Image Map |  Sequence Search |  Protein Motif Search |  Repeat Search |  DNA/RNA Motif Search |  Home

Human Herpesvirus 2 Search Results

Record: 1 of 1  
MiniMap IGR11 IGR13 IGR14 UL18, - HHVTW020 UL16, - HHVTW018 UL13, - HHVTW015 UL17, - HHVTW019 UL19, - HHVTW021 UL15, - HHVTW017 UL18, - HHVTW020 UL16, - HHVTW018 UL13, - HHVTW015 UL17, - HHVTW019 UL19, - HHVTW021 UL15, - HHVTW017 UL18, - HHVTW020 UL16, - HHVTW018 UL13, - HHVTW015 UL17, - HHVTW019 UL19, - HHVTW021 UL14, - HHVTW016 UL14, - HHVTW016 UL15, - HHVTW017 UL15.5, - HHVTW019.1 UL15.5, - HHVTW019.1


Gene ID:HHVTW019

GenBank Locus Tag:

DNA Molecule Name:
1  

GenBank ID:
1869839

Gene Name:
UL17  

Definition:
tegument protein

Cellular Location:
[Evidence]

Gene Start:
33471

Gene Stop:
31363

Gene Length:
2109

Molecular Weight*:
74696

pI*:
8.50

Net Charge*:
12.00

EC:
 

Functional Class:
virion production; DNA cleavage  
virion production; DNA packaging  

Gene Ontology:

Pathway: pathway table

Secondary Evidence:
Taus NS, Salmon B, Baines JD, The herpes simplex virus 1 UL 17 gene is required for localization of capsids and major and minor capsid proteins to intranuclear sites where viral DNA is cleaved and packaged, Virology 1998 Dec 5;252(1):115-25, Medline: 99092481.

Salmon B, Cunningham C, Davison AJ, Harris WJ, Baines JD, The herpes simplex virus type 1 U(L)17 gene encodes virion tegument proteins that are required for cleavage and packaging of viral DNA, J Virol 1998 May;72(5):3779-88, Medline: 98216738.

McGeoch,D.J., Dalrymple,M.A., Davison,A.J., Dolan,A., Frame,M.C.,, McNab,D., Perry,L.J., Scott,J.E. and Taylor,P., The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1, J. Gen. Virol. 69 (Pt 7), 1531-1574 (1988), Medline: 88274327.


Comment:
UL17 is coded entirely in the intron of UL15 and belongs to a family that includes HSV-1 UL17,HSV-6 ORF10R, EHV-1 45, HCMV UL93, EBV BGLF1, and VZV 43. Roizman (PNAS vol 63, 11307-12, 1996, Medline: 97030190) assigns it gamma-1 expression regulation.

Blast Summary:  PSI-Blast Search
Residues 1-702 of the UL17 protein are 81% similar using gapped BLAST to residues 1-703 of the UL17 protein in Human herpesvirus 1 (strain 17) and 36% similar over 720 aa to Equine herpesvirus 1 (gene 45), 35% similar over 718 aa to Equine herpesvirus 4 (gene 45), 35% similar over 724 aa to Bovine herpesvirus 1 (UL17), and less similar to Human herpesvirus 3 (gene 43) and other Alphaherpesvirinae.

Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|9629286|ref|NP_044486.1| UL17 [Human herpesvirus 2] >gnl|BL_O...  1414   0.0  
 gi|9629396|ref|NP_044618.1| UL17 [Human herpesvirus 1] >gnl|BL_O...  1149   0.0  
 gi|30984445|ref|NP_851876.1| tegument protein [Cercopithecine he...   937   0.0  
 gi|9626783|ref|NP_041055.1| ORF 45 [Equine herpesvirus 1] >gnl|B...   444   e-123
 gi|9629772|ref|NP_045263.1| 45 [Equine herpesvirus 4] >gnl|BL_OR...   432   e-119
 gi|9629859|ref|NP_045343.1| UL17 protein [Bovine herpesvirus 1] ...   387   e-106
 gi|28395423|gb|AAO38881.1| UL17 [Pseudorabies virus]                  347   6e-94
 gi|9625917|ref|NP_040166.1| tegument protein [Human herpesvirus ...   337   6e-91
 gi|13242436|ref|NP_077458.1| unknown [Cercopithecine herpesvirus...   321   3e-86
 gi|10180721|gb|AAG14209.1|AF243438_24 UL17 tegument protein-like...   279   1e-73


COGS Summary:  COGS Search
None.

Blocks Summary:  Blocks Search
No significant hits.

ProDom Summary:  Protein Domain Search
Residues 1-699 constitute a UL17 domain as seen in P89440_VVVVV. Residues 100-133 are 52% similar to a UL17 domain as seen in UL17_EBV.

Paralogs:  Local Blast Search
None.

Pfam Summary:  Pfam Search
None.

Structural Feature(s):
Feature Type  Start  Stop
non-globular  
58  
372
non-globular  
407  
506

Top PDB Hits:
None.

Gene Protein Sequence:
MNAHFANEVQYDLTRDPSSPASLIHVIISSECLAAAGVPLSALVRGRPDG
GAAANFRVETQTRAHATGDCTPWRSAFAAYVPADAVGAILAPVIPAHPDL
LPRVPSAGGLFVSLPVACDAQGVYDPYTVAALRLAWGPWATCARVLLFSY
DELVPPNTRYAADGARLMRLCRHFCRYVARLGAAAPAAATEAAAHLSLGM
GESGTPTPQASSVSGGAGPAVVGTPDPPISPEEQLTAPGGDTATAEDVSI
TQENEEILALVQRAVQDVTRRHPVRARPKHAASGVASGLRQGALVHQAVS
GGALGASDAEAVLAGLEPPGGGRFASRGGPRAAGEDVLNDVLTLVPGTAK
PRSLVEWLDRGWEALAGGDRPDWLWSRRSISVVLRHHYGTKQRFVVVSYE
NSVAWGGRRARPPRLSSELATALTEACAAERVVRPHQLSPAAQTALLRRF
PALEGPLRHPRPVLQPFDIAAEVAFVARIQIACLRALGHSIRAALQGGPR
IFQRLRYDFGPHQSEWLGEVTRRFPVLLENLMRALEGTAPDAFFHTAYAL
AVLAHLGGQGGRGRRRRLVPLSDDIPARFADSDAHYAFDYYSTSGDTLRL
TNRPIAVVIDGDVNGREQSKCRFMEGSPSTAPHRVCEQYLPGESYAYLCL
GFNRRLCGLVVFPGGFAFTINTAAYLSLADPVARAVGLRFCRGAATGPGL
VR$

Gene Nucleotide Sequence:  Sequence Viewer
ATGAACGCGCACTTTGCCAACGAGGTCCAATACGATCTCACCCGGGACCC
GAGCAGCCCCGCCTCGCTGATTCACGTCATCATCTCCAGCGAGTGCCTGG
CGGCGGCGGGGGTCCCGCTGTCCGCCCTCGTGCGCGGCCGCCCCGACGGT
GGGGCGGCCGCGAACTTCCGGGTCGAAACCCAGACCCGGGCCCACGCGAC
CGGCGACTGCACCCCGTGGCGTTCGGCGTTTGCCGCCTACGTGCCGGCGG
ATGCGGTGGGGGCGATCCTAGCCCCCGTCATCCCGGCGCACCCGGACCTC
CTGCCGCGCGTCCCCAGCGCGGGCGGGCTGTTCGTCTCCCTGCCGGTCGC
GTGCGACGCCCAAGGCGTGTACGACCCGTACACGGTCGCGGCGCTGCGCC
TGGCGTGGGGCCCGTGGGCGACCTGTGCCCGCGTGCTCCTGTTCAGTTAC
GACGAGCTCGTCCCGCCAAACACGCGATACGCGGCCGACGGCGCGCGCCT
CATGCGCCTCTGTCGCCACTTTTGTCGCTACGTCGCGCGGCTGGGGGCCG
CGGCTCCCGCCGCCGCGACGGAGGCGGCGGCCCACCTGTCCCTGGGGATG
GGGGAAAGCGGCACCCCCACTCCCCAGGCGTCCTCGGTCTCGGGCGGGGC
CGGGCCGGCCGTTGTCGGCACCCCAGACCCCCCCATCTCCCCGGAGGAGC
AGCTCACGGCCCCGGGAGGCGACACGGCCACCGCGGAGGACGTGTCCATC
ACGCAAGAGAACGAGGAGATCCTCGCGCTGGTCCAGCGGGCCGTGCAGGA
CGTCACCCGCCGCCACCCGGTCCGCGCGCGCCCCAAGCACGCGGCCTCCG
GCGTCGCCTCGGGGCTCCGCCAGGGCGCCCTGGTCCACCAGGCCGTCAGC
GGGGGAGCCCTGGGCGCGTCGGACGCGGAGGCGGTGCTGGCGGGCCTGGA
GCCGCCCGGCGGGGGGCGCTTTGCCAGCCGGGGGGGCCCCCGGGCCGCGG
GCGAGGACGTCCTCAACGACGTGCTCACCCTCGTGCCGGGGACCGCCAAG
CCGCGATCGCTGGTCGAGTGGCTGGACCGCGGGTGGGAAGCTCTGGCCGG
CGGCGACCGGCCCGACTGGCTGTGGAGCCGTCGCTCCATCTCCGTGGTCC
TGCGCCATCACTACGGGACCAAGCAGCGCTTCGTCGTCGTCTCCTACGAG
AATTCGGTGGCGTGGGGCGGGCGACGCGCCCGCCCCCCGCGGCTGTCCTC
CGAGCTGGCCACGGCCCTGACGGAGGCCTGTGCCGCCGAGCGCGTCGTGC
GCCCCCACCAGCTGTCCCCCGCGGCCCAGACGGCGCTGCTGCGTCGCTTT
CCCGCGCTCGAGGGACCCCTGCGCCACCCGCGCCCCGTGCTGCAGCCCTT
TGACATCGCGGCCGAGGTGGCCTTCGTCGCGCGCATCCAGATCGCGTGTC
TGCGGGCCCTGGGCCACTCTATCCGGGCCGCGCTCCAAGGCGGCCCGCGC
ATCTTCCAGCGCCTGCGCTACGACTTTGGCCCCCACCAGAGCGAGTGGCT
AGGGGAGGTGACGCGGCGCTTCCCCGTGCTCCTGGAGAACCTGATGCGCG
CCCTCGAGGGGACCGCCCCCGACGCGTTCTTTCACACCGCGTACGCCCTG
GCCGTGCTGGCGCATCTGGGCGGCCAGGGCGGTCGGGGGCGGCGGCGGCG
GCTCGTCCCTCTCAGCGACGACATCCCCGCCCGCTTCGCCGACTCCGACG
CCCACTACGCGTTTGACTACTACAGCACCAGCGGAGACACGCTGCGCCTC
ACCAACCGTCCAATCGCAGTGGTGATTGACGGTGACGTCAATGGACGCGA
GCAGAGTAAATGTCGCTTCATGGAGGGCAGCCCCTCCACTGCCCCACACA
GGGTCTGCGAGCAATACCTTCCGGGAGAGAGCTACGCGTACCTCTGCCTT
GGGTTCAATCGCCGCCTCTGCGGGCTAGTGGTCTTTCCGGGAGGCTTTGC
GTTTACCATTAACACCGCGGCGTACCTCAGCCTCGCAGACCCCGTCGCGC
GTGCCGTCGGACTCCGGTTCTGTCGCGGGGCGGCTACGGGACCCGGCCTT
GTCCGCTGA

Los Alamos National Laboratory • Est 1943

Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy