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Record: 1 of 1 MiniMap

Gene ID:HHVTW022GenBank Locus Tag:DNA Molecule Name: 1 GenBank ID: 1869842Gene Name: UL20 Definition: membrane proteinCellular Location: [Evidence]Gene Start: 41552Gene Stop: 40884Gene Length: 669Molecular Weight*: 24248pI*: 6.70Net Charge*: -0.57EC: Functional Class: virion entry and egress; capsid transport Gene Ontology:Pathway: pathway tableSecondary Evidence: Rajcani J, Kudelova M, Glycoprotein K of herpes simplex virus: a transmembrane protein encoded by the UL53 gene which regulates membrane fusion, Virus Genes 1999;18(1):81-90, Medline: 99266582. Avitabile E, Di Gaeta S, Torrisi MR, Ward PL, Roizman B, Campadelli-Fiume G, Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis, J Virol 1995 Dec;69(12):7472-82, Medline: 96078990. Ward PL, Campadelli-Fiume G, Avitabile E, Roizman B, Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1, J Virol 1994 Nov;68(11):7406-17, Medline: 95018654. Avitabile E, Ward PL, Di Lazzaro C, Torrisi MR, Roizman B, Campadelli-Fiume G, The herpes simplex virus UL20 protein compensates for the differential disruption of exocytosis of virions and viral membrane glycoproteins associated with fragmentation of the Golgi apparatus, J Virol 1994 Nov;68(11):7397-405, Medline: 95018653. Baines JD, Ward PL, Campadelli-Fiume G, Roizman B, The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress, J Virol 1991 Dec;65(12):6414-24, Medline: 92046298. MacLean CA, Efstathiou S, Elliott ML, Jamieson FE, McGeoch DJ, Investigation of herpes simplex virus type 1 genes encoding multiply inserted membrane proteins, J Gen Virol 1991 Apr;72 ( Pt 4):897-906, Medline: 91202126. McGeoch,Dalrymple,M.A., Davison,A.J.,D Dolan,A., Frame,M.C., McNab,D., Perry,L.J., Scott,J.E. and Taylor,P..J., The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1, J. Gen. Virol. 69 (Pt 7), 1531-1574 (1988), Medline: 88274327.Comment: Rajcani and Kudelova (1999) report that glycoprotein gK has an essential role in virion egress, acting along with glycoprotein gH and the UL20 protein. Ward et al. (1994) report results consistent with the hypothesis that UL20 is a component of virion envelopes and membranes of virion transport vesicles and is selectively retained from the latter in a Golgi compartment of HHV1 infected cells. In HSV-1 UL20 is dispensable in cell culture and has gamma expression regulation (Roizman, PNAS 93:11307,1996, Medline: 97030190).Blast Summary: PSI-Blast Search Residues 1-222 of the UL20 protein are 82% similar to residues 1-222 of the UL20 protein in Human herpesvirus 1 (strain 17) and 33% (32%) simmilar over 127 aa to Equine herpesvirus 1 (4) (gene 41) and weakly similar to membrane proteins in other Alphaherpesvirinae.Top Blast Hits: Updated monthly Click here to view the entire PsiBlast results. gi|9629289|ref|NP_044489.1| integral membrane protein [Human her... 454 e-127 gi|9629400|ref|NP_044621.1| integral membrane protein [Human her... 384 e-106 gi|28804708|dbj|BAC58109.1| integral membrane protein [Baboon he... 300 1e-80 gi|28804696|dbj|BAC58099.1| integral membrane protein [Cercopith... 298 3e-80 gi|28804714|dbj|BAC58114.1| integral membrane protein [Cercopith... 296 2e-79 gi|28804702|dbj|BAC58104.1| integral membrane protein [Cercopith... 295 3e-79 gi|28804655|dbj|BAC58059.1| integral membrane protein [Cercopith... 294 6e-79 gi|30984448|ref|NP_851879.1| virion membrane protein [Cercopithe... 294 6e-79 gi|20452457|gb|AAM22105.1|AF501667_4 integral membrane protein [... 292 2e-78 gi|13378318|gb|AAK18746.1| integral membrane protein UL20 [Bovin... 251 8e-66COGS Summary: COGS Search None.Blocks Summary: Blocks Search None.ProDom Summary: Protein Domain Search Residues 21-126 and 127-222 constitute integral membrane domains as seen in P89443_VVVVV. Residues 39-129 are 36% similar to a an integral membrane domain as seen in Q04531_VVVVV.Paralogs: Local Blast Search None.Pfam Summary: Pfam Search None.Structural Feature(s):

`Feature Type`	`Start`	`Stop`
`transmembrane`	`65`	`82`
`transmembrane`	`95`	`114`
`transmembrane`	`132`	`149`
`transmembrane`	`185`	`209`

Top PDB Hits: None.Gene Protein Sequence: MTMRDDVPLLDRELVDEAACGGEDGELPLDEQFSLSSYGTSDFFVSSAYS RLPPHTQPVFSKRVVMFAWSFLVLKPLELVAAGMYYGWTGRAVAPACIIA AVLAYYVTWLARALLLYVNIKRDRLPLSPPVFWGLCVIMGGAALCALVAA AHETFSPDGLFHWITASQLLPRTDPLRARSLGIACAAGAAMWVAAADCFA AFTNFFLARFWTRAILKAPVAF$Gene Nucleotide Sequence: Sequence Viewer ATGACAATGCGGGATGATGTTCCTTTGTTGGATCGCGAGCTGGTAGACGA GGCCGCGTGTGGCGGGGAGGACGGAGAACTGCCGCTCGATGAACAGTTTT CGCTGTCCTCGTACGGCACGTCTGATTTTTTTGTCAGTTCGGCCTACTCG CGTCTTCCGCCCCACACCCAGCCGGTCTTTTCCAAGCGGGTGGTGATGTT TGCTTGGTCGTTCCTGGTCCTCAAGCCGCTGGAGCTGGTGGCCGCGGGCA TGTATTACGGGTGGACCGGACGGGCGGTGGCGCCGGCATGTATTATAGCC GCCGTCCTCGCCTACTATGTCACGTGGCTGGCACGGGCGCTCCTCCTGTA CGTGAACATCAAACGGGATCGCCTGCCGTTGTCGCCACCCGTGTTTTGGG GGTTGTGCGTGATCATGGGCGGCGCGGCCCTGTGCGCCCTGGTGGCGGCC GCCCATGAGACGTTCAGTCCCGACGGGCTTTTCCATTGGATCACCGCCAG CCAGCTGCTGCCCCGCACGGATCCCCTCCGCGCCCGTTCTCTGGGAATCG CCTGCGCGGCCGGCGCCGCCATGTGGGTGGCGGCGGCGGACTGCTTTGCC GCCTTTACCAACTTTTTTCTAGCACGCTTTTGGACCAGGGCCATCTTGAA GGCACCCGTCGCGTTCTAA

Los Alamos National Laboratory • Est 1943