Gene ID:HHVTW059
GenBank Locus Tag:
DNA Molecule Name:
1
GenBank ID:
136947
Gene Name:
UL55
Definition:
unknown (UL55_HSV2H)
Cellular Location:
[Evidence]
Gene Start:
116342
Gene Stop:
116902
Gene Length:
561
Molecular Weight*:
20426
pI*:
9.50
Net Charge*:
11.72
EC:
Functional Class:
Gene Ontology:
Pathway: pathway table
Primary Evidence:
Yamada H, Jiang YM, Oshima S, Daikoku T, Yamashita Y, Tsurum
T, Nishiyama Y, Characterization of the UL55 gene product of herpes simplex virus type 2, Gen Virol 1998 Aug;79 ( Pt 8):1989-95, Medline: 98378050.
McGeoch DJ, Cunningham C, McIntyre G, Dolan A, Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2, J Gen Virol 1991 Dec;72 ( Pt 12):3057-75 , Medline: 92113549.
Secondary Evidence:
Nash TC, Spivack JG, The UL55 and UL56 genes of herpes simplex virus type 1 are not required for viral replication, intraperitoneal virulence, or establishment of latency in mice, Virology 1994 Nov 1;204(2):794-8, Medline: 95027710.
Perry LJ, McGeoch DJ, The DNA sequences of the long repeat region a region in the genome of herpes simplex virus type 1, J Gen Virol 1988 Nov;69 ( Pt 11):2831-46, Medline: 89036163.
Perry LJ, McGeoch DJ, The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1, J Gen Virol 1988 Nov;69: 2831-46, Medline: 89036163.
Comment:
Yamada et al. (1998) identify the UL55 protein in HSV-2. Using indirect immunofluorescence studies they localize it within and at the periphery of the nucleus as discrete granules at late times post-infection. Nuclear fractionation studies show that the protein is associated with the nuclear matrix of infected cells, adjacent to compartments called assemblons. It was not detected in purified virions. Yamada et al. conclude that the UL55 protein may play a role in virion assembly or maturation.
UL55 is dispensable for intraperitoneal virulence and establishment of latent infection in vivo, see Nash and Spivack (1994) and it's expression regulation is unknown, see Roizman, PNAS 93:11307 (1996) Medline: 97030190.
Blast Summary: PSI-Blast Search
Residues 1-183 of the UL55 protein are 85% similar using gapped BLAST to residues 1-185 of UL55 in Human herpesvirus 1 (strain 17) and weakly similar to Equine herpesvirus 1 and 4 (P28963 and AAC59557), Human herpesvirus 3 (P09268) and Gallid herpesvirus 1 (BAA33006).
Top Blast Hits: Updated monthly
Click here to view the entire PsiBlast results.
COGS Summary: COGS Search
None.
Blocks Summary: Blocks Search
Residues 29-65 and 111-119 may represent blocks PF01673A and C (Herpesvirus putative major envelope glycoprotein) with a combined E value of 0.86.
ProDom Summary: Protein Domain Search
Residues 11-162 and 163-186 constitute the UL55 protein domains as seen in UL55_HSV2H.
Paralogs: Local Blast Search
None.
Pfam Summary: Pfam Search
None.
Top PDB Hits:
None.
Gene Protein Sequence:
MTTTPLSNLFLRAPDITHVAPPYCLNATWQAENALHTTKTDPACLAARSY
LVRASCSTSGPIHCFFFAVYKDSQHSLPLVTELRNFADLVNHPPVLRELE
DKRGGRLRCTGPFSCGTIKDVSGASPAGEYTINGIVYHCHCRYPFSKTCW
LGASAALQHLRSISSSGTAARAAEQRRHKIKIKIKV$
Gene Nucleotide Sequence: Sequence Viewer
ATGACAACGACGCCCCTCTCGAACCTGTTTTTACGGGCCCCGGACATCAC
CCACGTCGCCCCCCCGTACTGTCTGAATGCCACGTGGCAGGCCGAAAACG
CCCTGCACACGACCAAAACGGACCCCGCGTGCCTGGCCGCGCGGAGTTAT
TTAGTCCGCGCCTCCTGCTCGACCAGCGGCCCCATCCACTGTTTTTTCTT
TGCGGTGTACAAGGACTCGCAGCACTCCCTTCCGCTGGTTACCGAGCTCC
GCAACTTCGCGGACCTGGTCAACCACCCGCCCGTCTTGCGCGAACTAGAG
GATAAGCGTGGGGGGCGGCTGCGGTGCACGGGCCCATTCAGCTGCGGAAC
CATCAAGGACGTCTCCGGTGCATCCCCCGCGGGGGAATACACGATAAACG
GTATCGTGTACCACTGTCACTGTCGGTATCCGTTCTCCAAAACCTGCTGG
CTCGGGGCATCCGCGGCCCTACAACACCTTCGCTCTATAAGCTCAAGCGG
CACGGCCGCTCGCGCGGCAGAACAGCGACGCCACAAAATCAAAATCAAAA
TCAAGGTATAA