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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0002 IGR0001 IGR1674 IGR0005 IGR0003 IGR0004 IGR1675 IGR1676 PG0003 PG0005 PG0006 PG1947 PG1945 PG0002 PG1949 PG0004 dnaA, - PG0001 PG1948 PG0003 PG0005 PG0006 PG1947 PG1945 PG0002 PG1949 PG0004 dnaA, - PG0001 PG1948 PG0003 PG0005 PG0006 PG1945 PG0002 PG1949 PG0004 dnaA, - PG0001 PG1948 PG1947


LANL Gene ID: PG0001

GenBank Locus Tag: PG0001

DNA Molecule Name:
1  

GenBank ID:
34539881

Gene Name:
dnaA  

Definition:
chromosomal replication initiator protein DNAA

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1

Gene Stop:
1419

Gene Length:
1419

Molecular Weight*:
53352

pI*:
7.40

Net Charge*:
2.44

EC:
 

Functional Class:
DNA metabolism; DNA replication, recombination and repair  

Gene Ontology:
Biological process
  GO:0006270    DNA replication initiation
  GO:0006275    regulation of DNA replication

Molecular function
  GO:0000166    nucleotide binding
  GO:0003677    DNA binding
  GO:0003688    DNA replication origin binding
  GO:0005524    ATP binding
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Secondary Evidence:
Ohmori,H., Kimura,M., Nagata,T. and Sakakibara,Y.
Structural analysis of the dnaA and dnaN genes of Escherichia coli
Gene 28 (2), 159-170 (1984)
PubMed: 6234204


Comment:
Predicted dnaK protein is PG1069. For polIII sequences, see PG1615, PG0031, PG0831, PG1245, PG1614.

TIGR ID: PG0001

Human Oral Microbiome Database:
View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Numerous hits to chromosomal replication proteins; e.g. residues
11-448 are 33% similar to dnaA protein (IQECDA) of E. coli; residues 7-461 are 32% similar to chromosomal replication protein (dnaA) (U32780) of Haemophilus influenzae, residues 10-461 are 31% similar to dnaA protein (X14791)of Pseudomonas putida.

This sequence is orthologous to CT250, CT275 and to BT2143.

Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539881|ref|NP_904360.1|  chromosomal replication initia...   961   0.0  
 gi|150006675|ref|YP_001301418.1|  chromosomal replication in...   482   e-134
 gi|154491703|ref|ZP_02031329.1|  hypothetical protein PARMER...   463   e-128
 gi|53715109|ref|YP_101101.1|  chromosomal replication initia...   432   e-119
 gi|153808748|ref|ZP_01961416.1|  hypothetical protein BACCAC...   418   e-115
 gi|156109554|gb|EDO11299.1|  hypothetical protein BACOVA_032...   414   e-114
 gi|150002609|ref|YP_001297353.1|  chromosomal replication in...   412   e-113
 gi|29347553|ref|NP_811056.1|  chromosomal replication initia...   408   e-112
 gi|156861323|gb|EDO54754.1|  hypothetical protein BACUNI_017...   400   e-110
 gi|88803646|ref|ZP_01119170.1|  chromosomal replication init...   383   e-104


InterPro Summary:  InterProScan

InterPro
IPR001957
Family
Bacterial chromosomal replication initiator protein, DnaA
PR00051 [171-191]T 4.8E-36 PR00051 DNAA[203-217]T 4.8E-36 PR00051 DNAA[235-249]T 4.8E-36 PR00051 DNAA[269-296]T 4.8E-36 PR00051 DNAA[431-450]T 4.8E-36 PR00051 DNAA DNAA
TIGR00362 [5-471]T 3.03605069216282E-107 TIGR00362 DnaA DnaA
PS01008 [431-450]T 8.0E-5 PS01008 DNAA DNAA
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [170-374]T 4.49999999999996E-8 SM00382 AAA AAA
InterPro
IPR010921
Domain
Trp repressor/replication initiator
SSF48295 [367-473]T 2.7000000000000003E-28 SSF48295 Trp_repress_rep Trp_repress_rep
InterPro
IPR013159
Domain
Chromosomal replication initiator, DnaA C-terminal
PF08299 [381-450]T 4.00000300869916E-21 PF08299 Bac_DnaA_C Bac_DnaA_C
SM00760 [381-450]T 1.29999999999989E-30 SM00760 Bac_DnaA_C Bac_DnaA_C
InterPro
IPR013317
Domain
Chromosomal replication initiator, DnaA
PF00308 [137-356]T 4.89996723796366E-66 PF00308 Bac_DnaA Bac_DnaA
noIPR
unintegrated
unintegrated
G3DSA:1.10.1750.10 [368-471]T 8.70001261213413E-26 G3DSA:1.10.1750.10 G3DSA:1.10.1750.10 G3DSA:1.10.1750.10
G3DSA:3.40.50.300 [134-302]T 3.8000069709354504E-44 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
SSF52540 [135-350]T 7.700000000000002E-35 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 12 clades of COG0593
COG name: ATPase involved in DNA replication initiation
Functional Class: L
The phylogenetic pattern of COG0593 is -----qvcEbrHujgpolINX
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001957 (Bacterial chromosomal replication initiator protein, DnaA) with a combined E-value of 3.6e-54.
    IPB001957A    171-188
    IPB001957B    228-274
    IPB001957C    323-349
    IPB001957D    399-450


 ProDom Summary:  Protein Domain Search
Residues 281-448 are 37% similar to a (REPLICATION PROTEIN INITIATOR CHROMOSOMAL) protein domain (PD002151 which is seen in DNAA_PSEPU.

Residues 143-278 are 42% similar to a (PROTEIN ATP-BINDING REPLICATION INITIATOR) protein domain (PD002717 which is seen in DNAA_HAEIN.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 137 to 450 (E-value = 7.3e-105) place PG0001 in the Bac_DnaA family which is described as Bacterial dnaA protein (PF00308)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-54% similar to PDB:1L8Q CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR (E_value = 1.3E_44);
-54% similar to PDB:2HCB Structure of AMPPCP-bound DnaA from Aquifex aeolicus (E_value = 1.3E_44);
-67% similar to PDB:1J1V Crystal structure of DnaA domainIV complexed with DnaAbox DNA (E_value = 9.1E_11);
-51% similar to PDB:1BBT METHODS USED IN THE STRUCTURE DETERMINATION OF FOOT AND MOUTH DISEASE VIRUS (E_value = 9.1E_11);
-51% similar to PDB:1FOD STRUCTURE OF A MAJOR IMMUNOGENIC SITE ON FOOT-AND-MOUTH DISEASE VIRUS (E_value = 9.1E_11);

Gene Protein Sequence:
MNYHSTNVNEIWDACLRILQDIVDERAYRTWFLPIIPVSIEGDTLTLQVP
SQFFCEFLEGNFVEQLRTVLGRVIGPNASLQYNALVDNSSPKYPGTVTLA
GCADGGQAAEQFDVNLLHRHMPNAATHSEAQDFDTQLNSRLNFRNFYQSE
CNYVARSVAEAIAASPGNTPMNPFFIYGASGVGKTHLCHALGLRVREMHP
RLKVLYVSSHLFEMQFTTAARMGTINDFIAFYQQVDVLIIDDIQWLIGKK
KTQLAFFQVFNHLYMLGKQIVLTSDKPPVDLNGMEERLVTRMAGATCVKI
ERPDLKLRREILQQRTLQSGVRLDESVLNFIAENVCDNVRELEGTLVSLI
TNSVVVGKEIDLTFAKRIVRQAVRLEKKEVTIECIQQAVSRVFQVQIEQM
KSKSRKQDIVQARQVVMFLSKKHTAQSLSAIGELMGGRNHATVLHGCRCV
TNEMEMNASFRSSVERAEQLIAN

Gene Nucleotide Sequence:  Sequence Viewer
ATGAACTACCACTCGACCAATGTAAATGAAATATGGGACGCGTGTCTTCG
CATCCTTCAGGATATTGTGGATGAGCGAGCATACCGTACATGGTTCTTGC
CTATCATACCGGTATCTATCGAGGGCGATACGCTTACCTTACAAGTGCCG
AGTCAGTTCTTCTGTGAGTTTTTGGAGGGCAATTTCGTAGAGCAGCTGCG
TACGGTGTTGGGGCGTGTTATAGGTCCCAACGCATCATTACAGTATAATG
CCCTTGTAGACAACAGTTCGCCCAAATATCCCGGCACGGTGACATTGGCC
GGTTGTGCCGACGGTGGACAGGCAGCCGAACAGTTCGATGTCAATTTGCT
ACACAGGCACATGCCCAATGCAGCCACCCATAGCGAAGCACAGGATTTCG
ACACGCAGCTCAATAGCAGGCTCAATTTCCGCAACTTCTACCAGAGCGAA
TGCAACTATGTAGCTCGCTCAGTGGCTGAAGCCATCGCCGCCAGCCCGGG
CAATACGCCGATGAATCCATTCTTTATATATGGAGCTTCCGGTGTGGGCA
AGACGCACTTGTGCCATGCCTTGGGCCTTCGTGTCAGAGAGATGCACCCC
CGGTTGAAAGTACTATACGTATCGAGTCATTTGTTCGAGATGCAGTTCAC
TACGGCAGCCCGTATGGGGACGATCAATGACTTCATCGCATTCTACCAGC
AAGTGGATGTACTGATCATCGATGACATCCAATGGTTGATCGGCAAGAAG
AAAACGCAATTAGCTTTCTTCCAAGTGTTCAATCACCTCTATATGCTTGG
CAAACAGATAGTCTTGACGTCGGACAAACCTCCTGTAGACCTTAACGGGA
TGGAGGAGCGGTTGGTCACTCGTATGGCCGGTGCTACCTGTGTCAAGATA
GAACGTCCGGATTTGAAGTTGCGTCGTGAGATACTCCAGCAGCGTACGCT
TCAAAGCGGTGTCCGGCTGGACGAATCGGTGCTGAACTTTATCGCCGAAA
ATGTCTGCGACAATGTTCGTGAACTGGAAGGCACCCTCGTATCCTTGATC
ACAAATTCGGTGGTTGTAGGTAAGGAAATCGACCTGACCTTTGCCAAACG
GATTGTCCGCCAAGCTGTCAGACTGGAGAAAAAGGAAGTCACCATCGAGT
GCATCCAGCAGGCAGTCAGCAGAGTATTTCAGGTGCAGATAGAGCAGATG
AAAAGCAAGAGTCGGAAGCAGGATATCGTACAGGCTCGTCAGGTGGTCAT
GTTCCTCTCCAAAAAACACACGGCTCAGTCCTTGTCGGCTATCGGCGAAC
TGATGGGAGGACGTAACCATGCCACCGTACTCCACGGCTGTCGCTGTGTG
ACGAACGAGATGGAGATGAATGCCTCATTCCGTTCATCGGTAGAACGTGC
CGAACAGTTGATCGCCAAT

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