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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap tRNA-Asn-2 tRNA-Asn-1 IGR0002 IGR0001 IGR0005 IGR0007 IGR0003 IGR0004 IGR1676 IGR0006 ISPg5, - PG0008 ISPg5, - PG0007 PG0003 PG0005 PG0006 PG0002 PG1949 PG0004 dnaA, - PG0001 PG1948 ISPg5, - PG0008 ISPg5, - PG0007 PG0003 PG0005 PG0006 PG0002 PG1949 PG0004 dnaA, - PG0001 PG1948 Type: IS element, Name: ISPg5 - 8 ISPg5, - PG0008 ISPg5, - PG0007 PG0003 PG0005 PG0006 PG0002 PG0004 dnaA, - PG0001 PG1948 PG1949


LANL Gene ID: PG0004

GenBank Locus Tag: PG0004

DNA Molecule Name:
1  

GenBank ID:
34539884

Gene Name:


Definition:
probable phosphoribosyltransferase transcriptional regulator

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
3108

Gene Stop:
3809

Gene Length:
702

Molecular Weight*:
26088

pI*:
6.20

Net Charge*:
-3.45

EC:
 

Functional Class:
Regulatory functions  

Gene Ontology:
Biological process
  GO:0006342    chromatin silencing
  GO:0006355    regulation of transcription, DNA-dependent

Cellular component
  GO:0005677    chromatin silencing complex

Molecular function
  GO:0003677    DNA binding


Pathway: pathway table

Comment:
TIGR ID: PG0004

Proteomic Data: Proteomic Data Search
TIGR Annotationtranscriptional regulator, Sir2 family, GroupP (regulatory functions)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG00040.960.0221.820.000345.366.4e-121.820.00034
LANLPG00041.943.5440.95923.51
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous hits to transcriptional regulatory proteins and hypothetical proteins; e.g. residues 4-185 are 45% similar to transcriptional regulatory protein Sir2 family (AE000987) of Archaeoglobus fulgidus, residues 2-183 are 39% similar to transcriptional regulatory protein Sir2 (AJ248286) of Pyrococcus abyssi, residues 4-229 are 51% similar to putative protein (AE001545) of Helicobacter pylori J99.

Residues 4-189 are 46% similar to a probable nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) of Vibrio cholerae (AE004229). See also U89687 od Salmonella.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539884|ref|NP_904363.1|  NAD-dependent deacetylase [Por...   479   e-134
 gi|150009308|ref|YP_001304051.1|  transcriptional regulator ...   310   4e-83
 gi|154493799|ref|ZP_02033119.1|  hypothetical protein PARMER...   309   8e-83
 gi|53715792|ref|YP_101784.1|  NAD-dependent deacetylase [Bac...   275   1e-72
 gi|156110562|gb|EDO12307.1|  hypothetical protein BACOVA_021...   275   2e-72
 gi|156859050|gb|EDO52481.1|  hypothetical protein BACUNI_040...   273   5e-72
 gi|29348384|ref|NP_811887.1|  NAD-dependent deacetylase [Bac...   273   5e-72
 gi|153806980|ref|ZP_01959648.1|  hypothetical protein BACCAC...   269   8e-71
 gi|150003994|ref|YP_001298738.1|  putative nicotinate mononu...   269   1e-70
 gi|150025851|ref|YP_001296677.1|  NAD-dependent deacetylase ...   255   1e-66


InterPro Summary:  InterProScan

InterPro
IPR003000
Family
Silent information regulator protein Sir2
PTHR11085 [11-229]T 5.89998809405682E-45 PTHR11085 SIR2 SIR2
PF02146 [11-181]T 6.399986334035938E-58 PF02146 SIR2 SIR2
PS50305 [1-234]T 0.0 PS50305 SIRTUIN SIRTUIN
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.1220 [1-229]T 1.29999924468183E-31 G3DSA:3.40.50.1220 G3DSA:3.40.50.1220 G3DSA:3.40.50.1220
SSF52467 [3-229]T 2.1999999999999996E-64 SSF52467 SSF52467 SSF52467


COGS Summary:  COGS Search
BeTs to 9 clades of COG0846
COG name: Putative NaMN:DMB phosphoribosyltransferase (CobB)/SIR2 transcriptional regulator
Functional Class: H
The phylogenetic pattern of COG0846 is A--kYqv-ebr-uj-------
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** BP02659 (PROTEIN SIR2 TRANSCRIPTION R) with a combined E-value of 6.6e-15.
    BP02659A    5-21
    BP02659C    67-116
    BP02659D    141-158
    BP02659E    169-203


 ProDom Summary:  Protein Domain Search
Residues 33-202 are 56% similar to a (PROTEIN SIR2 TRANSCRIPTION REGULATION REPRESSOR) protein domain (PD002659 which is seen in Q9ZAB8_BBBBB.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 11 to 181 (E-value = 1.5e-58) place PG0004 in the SIR2 family which is described as Sir2 family (PF02146)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable signal  
1  
18
gram negative signal  
1  
18
transmembrane  
169  
185

Top PDB Hits:
-66% similar to PDB:1S5P Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli. (E_value = 1.5E_41);
-61% similar to PDB:1ICI CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX (E_value = 3.0E_34);
-61% similar to PDB:1M2G Sir2 homologue-ADP ribose complex (E_value = 3.0E_34);
-61% similar to PDB:1M2H Sir2 homologue S24A mutant-ADP ribose complex (E_value = 6.7E_34);
-61% similar to PDB:1M2J Sir2 homologue H80N mutant-ADP ribose complex (E_value = 1.9E_33);

Gene Protein Sequence:
MNKKRLVVLSGAGMSAESGISTFRDANGLWENYPVEDVASIDGFRRNPAL
VLKFYNARRRDYAGCKPNAGHIGLAEMEKEYDVRIITQNVDDLHERAGST
HVIHLHGELMKNRSVATDSVLYPVDPTNPDLHVGDLAPDGCQLRPFIVWF
GEAVPMIEPAIEEVTQADILVVIGTSLNVYPAAGLLNYAPRNCPIYLIDP
KPVRSTSRQDIRYIHAPATEGVRMLRQELRDIDR

Gene Nucleotide Sequence:  Sequence Viewer
ATGAATAAGAAAAGACTCGTCGTCTTGAGTGGCGCAGGCATGAGTGCCGA
AAGCGGCATATCGACTTTTCGTGATGCCAACGGATTGTGGGAGAATTATC
CCGTCGAGGATGTGGCCTCTATCGATGGGTTTAGGCGCAATCCTGCCCTC
GTTCTCAAGTTCTACAATGCACGCCGACGCGACTATGCCGGTTGCAAACC
GAATGCAGGCCATATTGGTTTGGCGGAAATGGAGAAGGAGTATGATGTAA
GAATCATCACGCAGAATGTGGATGATCTGCACGAGAGAGCAGGCAGCACA
CACGTCATTCATCTGCACGGAGAGTTGATGAAGAACAGATCTGTGGCCAC
AGACAGTGTGCTCTATCCCGTAGACCCGACCAATCCCGATCTGCATGTAG
GAGATCTGGCACCCGACGGCTGTCAGCTACGGCCGTTTATTGTGTGGTTT
GGAGAAGCTGTTCCGATGATAGAGCCGGCCATCGAAGAGGTAACACAGGC
AGACATTCTCGTTGTCATCGGCACCTCTCTCAACGTTTATCCGGCTGCCG
GACTGTTGAATTATGCTCCTCGCAACTGCCCCATCTATCTGATCGATCCA
AAGCCTGTGCGCAGCACCTCCCGGCAAGACATTCGGTATATCCATGCTCC
TGCCACGGAAGGCGTAAGGATGTTGCGGCAAGAACTCCGTGATATAGATC
GC

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