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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap tRNA-Asn-2 tRNA-Asn-1 IGR0002 IGR0001 IGR0005 IGR0007 IGR0003 IGR0004 IGR0008 IGR0006 ISPg5, - PG0008 ISPg5, - PG0007 PG0003 PG0005 PG0006 PG0002 PG0004 dnaA, - PG0001 clpC, - PG0009 ISPg5, - PG0008 ISPg5, - PG0007 PG0003 PG0005 PG0006 PG0002 PG0004 dnaA, - PG0001 clpC, - PG0009 Type: IS element, Name: ISPg5 - 8 ISPg5, - PG0008 ISPg5, - PG0007 PG0003 PG0005 PG0006 PG0002 PG0004 dnaA, - PG0001 clpC, - PG0009


LANL Gene ID: PG0006

GenBank Locus Tag: PG0006

DNA Molecule Name:
1  

GenBank ID:
34539886

Gene Name:


Definition:
probable integral membrane protein

Cellular Location:
Inner membrane, Cytoplasm [Evidence]

Gene Start:
6422

Gene Stop:
5097

Gene Length:
1326

Molecular Weight*:
48303

pI*:
10.20

Net Charge*:
11.49

EC:
 

Functional Class:
Uncategorized  

Gene Ontology:
Biological process
  GO:0006855    multidrug transport

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0015238    drug transporter activity
  GO:0015297    antiporter activity


Pathway: pathway table

Comment:
TIGR ID: PG0006

Human Oral Microbiome Database:
View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST to conserved hypothetical proteins e.g., residues 2-430 are 23% similar to AE001538 of Helicobacter pylori; residues 7-436 are 27% similar to MJ0709 of Methanococcus jannaschii; residues 2-430 are 24% similar to AE000624 of Helicobacter pylori; residues 5-434 are 27% similar to AE001810 of Thermotoga maritima.

This sequence is similar to BT2121.

Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539886|ref|NP_904365.1|  MATE efflux family protein [Po...   773   0.0  
 gi|154491846|ref|ZP_02031472.1|  hypothetical protein PARMER...   425   e-117
 gi|150010250|ref|YP_001304993.1|  MATE efflux family protein...   412   e-113
 gi|29347531|ref|NP_811034.1|  putative Na+-driven multidrug ...   333   2e-89
 gi|106894286|ref|ZP_01361407.1|  Multi antimicrobial extrusi...   330   1e-88
 gi|15894170|ref|NP_347519.1|  Probable cation efflux pump (m...   322   3e-86
 gi|156861283|gb|EDO54714.1|  hypothetical protein BACUNI_016...   320   9e-86
 gi|156109587|gb|EDO11332.1|  hypothetical protein BACOVA_032...   320   1e-85
 gi|28210337|ref|NP_781281.1|  Na+ driven multidrug efflux pu...   315   3e-84
 gi|126699145|ref|YP_001088042.1|  putative drug/sodium antip...   315   5e-84


InterPro Summary:  InterProScan

InterPro
IPR002528
Family
Multi antimicrobial extrusion protein MatE
PTHR11206 [21-437]T 1.6e-129 PTHR11206 MULTIDRUG RESISTANCE PUMP MULTIDRUG RESISTANCE PUMP
PF01554 [7-168]T 2.1e-27 PF01554 MatE[230-395]T 4.2e-14 PF01554 MatE MatE
TIGR00797 [7-407]T 3e-40 TIGR00797 matE: MATE efflux family protein matE: MATE efflux family protein
InterPro
IPR015522
Family
Na+ driven multidrug efflux pump
PTHR11206:SF6 [21-437]T 1.6e-129 PTHR11206:SF6 NA+ DRIVEN MULTIDRUG EFFLUX PUMP NA+ DRIVEN MULTIDRUG EFFLUX PUMP
noIPR
unintegrated
unintegrated
signalp [1-16]? NA signalp signal-peptide signal-peptide
tmhmm [5-25]? NA tmhmm transmembrane_regions[39-59]? NA tmhmm transmembrane_regions[80-100]? NA tmhmm transmembrane_regions[124-142]? NA tmhmm transmembrane_regions[152-170]? NA tmhmm transmembrane_regions[180-200]? NA tmhmm transmembrane_regions[215-235]? NA tmhmm transmembrane_regions[271-291]? NA tmhmm transmembrane_regions[312-332]? NA tmhmm transmembrane_regions[346-364]? NA tmhmm transmembrane_regions[379-401]? NA tmhmm transmembrane_regions[407-427]? NA tmhmm transmembrane_regions transmembrane_regions


COGS Summary:  COGS Search
BeTs to 14 clades of COG0534
COG name: Probable cation efflux pump (multidrug resistance protein)
Functional Class: R
The phylogenetic pattern of COG0534 is amtKYqVCEBrhUJgpOl---
Number of proteins in this genome belonging to this COG is 4
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 262-430 are 22% similar to a (PROTEIN CONSERVED INTEGRAL MEMBRANE) protein domain (PD114832 which is seen in O25796_HELPY.

Residues 100-243 are 26% similar to a (PROTEIN TRANSMEMBRANE MVIN MEMBRANE TRANSPORTER) protein domain (PD001019 which is seen in Q9ZK32_BBBBB.


Paralogs:  Local Blast Search
Residues 6-439 are 28% similar to PG1265, a conserved hypothetical protein (probable integral membrane protein). Residues 6-439 are 28% similar to PG0742,a conserved hypothetical membrane protein, and residues 1-415 are 19% similar to PG0577, a DNA damage-inducible protein. Residues 1-343 are 20% similar to PG1432, a DNA damage-inducible protein.

Pfam Summary:  Pfam Search
Residues 7 to 168 (E-value = 1.9e-27) place PG0006 in the MatE family which is described as MatE (PF01554)
Residues 230 to 395 (E-value = 3.6e-14) place PG0006 in the MatE family which is described as MatE (PF01554)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
39  
55
transmembrane  
83  
99
transmembrane  
153  
169
transmembrane  
180  
196
transmembrane  
217  
233
transmembrane  
267  
283
transmembrane  
310  
326
non-globular  
314  
442
transmembrane  
387  
403
transmembrane  
411  
427

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
LFHYALPAVVGTAVNSLYNIVDRIFIGNGVSEYALSGLAITFPILIFLMA
FGMLVGAGASVRVSILLGRKDIKEAEHTLANAIFLTFFTQALTIIPCYIF
MEPLLRLFGASERTLPYAMEYLQYVVPANIFSALSFGYNAIMRASGYPRK
AMITMIIGAMTNVVLDYIFIYPLGMGISGAAIATVVSMIVCSVYVLSHFF
RKDSIVRFHRSAFRLSLPVIGGITAIGVAPFAMHLTGSLVNIIMNRSFVS
YGETADATDLAIGAFGIINGYAMLFFMIIIGVAQGMQPIVGFNYGAKNPG
RVKSAYRYSCGVNLLVSFLGFALAMLMPRTIVSLFTNSEQMIELSASALR
TALIGLSLVGFQVTTTQFFQSIGFSHKAIFLSLTRQIIFLIPCLLIIPRF
MGLDGVWWSLPISDLASVVLSFVLITIQMKHFNQSKKTTFAE

Gene Nucleotide Sequence:  Sequence Viewer
TTGTTTCACTATGCTCTGCCGGCGGTGGTGGGTACAGCAGTCAATTCGCT
ATACAACATCGTAGACCGCATCTTCATCGGGAACGGGGTGAGCGAATATG
CCTTGTCGGGCTTGGCTATCACCTTCCCAATCCTGATCTTCCTGATGGCC
TTCGGTATGCTGGTAGGGGCCGGTGCGTCCGTGAGGGTCTCTATCCTGCT
GGGGAGAAAAGACATAAAGGAGGCCGAACACACACTGGCCAATGCCATCT
TCCTGACCTTCTTCACACAAGCCCTGACCATTATCCCCTGCTATATTTTC
ATGGAGCCGCTGCTTCGGCTGTTCGGAGCCAGCGAACGTACGTTGCCGTA
TGCCATGGAATACCTCCAATACGTGGTTCCTGCCAATATTTTCTCAGCTC
TGAGCTTCGGCTACAATGCTATCATGAGAGCTTCGGGCTATCCGCGCAAA
GCCATGATTACGATGATCATCGGGGCTATGACGAACGTGGTGCTGGACTA
CATCTTCATCTATCCGTTGGGGATGGGGATAAGCGGAGCCGCCATAGCGA
CTGTCGTCTCCATGATAGTATGTTCGGTCTACGTCCTTTCGCACTTTTTC
CGTAAGGACAGTATCGTACGTTTCCACCGCTCGGCTTTCCGCCTGTCCCT
GCCGGTGATCGGCGGCATAACGGCTATAGGGGTAGCACCCTTCGCCATGC
ACCTTACGGGCAGTCTGGTCAATATCATCATGAATCGTTCTTTCGTATCC
TACGGCGAGACAGCAGATGCTACCGACTTGGCCATCGGAGCATTCGGGAT
TATCAATGGCTATGCCATGCTCTTTTTCATGATTATCATCGGTGTGGCTC
AGGGGATGCAGCCGATCGTAGGTTTCAACTACGGGGCTAAAAATCCGGGA
CGGGTGAAGTCGGCCTATCGCTACAGTTGTGGCGTCAATCTACTGGTCAG
CTTTCTCGGTTTTGCTCTGGCTATGCTTATGCCGAGGACAATCGTGAGTC
TATTCACCAATAGCGAACAGATGATAGAGCTATCTGCTTCGGCTCTTCGC
ACGGCCTTGATCGGGCTTTCTCTGGTCGGCTTTCAAGTTACCACGACGCA
ATTCTTCCAAAGCATCGGCTTCAGCCATAAGGCTATTTTCCTGAGCCTAA
CGCGCCAGATCATCTTCCTGATTCCCTGTTTGCTGATTATCCCCCGATTC
ATGGGGTTGGACGGCGTGTGGTGGAGTCTGCCGATCAGCGATCTGGCCTC
GGTCGTTTTGTCTTTTGTGCTAATTACCATACAGATGAAGCATTTCAATC
AATCGAAAAAAACTACTTTCGCGGAG

Los Alamos National Laboratory • Est 1943

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