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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0014 IGR0011 IGR0013 IGR0010 IGR0009 IGR0012 PG0012 hisC, - PG0011 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 clpC, - PG0009 nagA,ybbD, - PG0010 PG0012 hisC, - PG0011 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 clpC, - PG0009 nagA,ybbD, - PG0010 PG0012 hisC, - PG0011 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 clpC, - PG0009 nagA,ybbD, - PG0010


LANL Gene ID: PG0011

GenBank Locus Tag: PG0012

DNA Molecule Name:
1  

Genomic Island ID:
1

GenBank ID:
34539892

 Gene Name:
hisC  

 Definition:
histidinol-phosphate aminotransferase

 Cellular Location:
Cytoplasm [Evidence]

 Gene Start:
14693

Gene Stop:
15718

Gene Length:
1026

Molecular Weight*:
39011

pI*:
6.30

Net Charge*:
-4.05

EC:
2.6.1.9  

 Functional Class:
Amino acid biosynthesis; Histidine family  

 Gene Ontology:
Biological process
  GO:0009058    biosynthetic process

Molecular function
  GO:0003824    catalytic activity
  GO:0016769    transferase activity, transferring nitrogenous groups
  GO:0030170    pyridoxal phosphate binding


 Pathway: pathway table
Histidine metabolism
Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Tyrosine metabolism

 Comment:
TIGR ID: PG0012

 Proteomic Data: Proteomic Data Search
TIGR AnnotationL-threonine-O-3-phosphate decarboxylase, putative, GroupB (biosynthesis of cofactors, prosthetic groups, and carriers)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG00122.538.9e-162.6301.575.8e-142.630
LANLPG00115.796.172.972.16
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST to histidinol-phosphate aminotransferase proteins; e.g. residues 17-339 are 27% similar to histidinol-phosphate aminotransferase of Synechocystis sp.(D90906), residues 67-336 are 27% similar to histidinol-phosphate aminotransferase (hisC) of Pyrococcus abyssi (AJ248283), resisdues 64-335 are 26% similar to 328aa long hypothetical histidinol-phosphate aminotransferase of Pyrococcus horikoshii (AP000002), residues 7-335 are 25% similar to histidinol-phosphate aminotransferase (hisC-2) Archaeoglobus fulgidus(AE000963).

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539892|ref|NP_904371.1|  L-threonine-O-3-phosphate deca...   722   0.0  
 gi|150008941|ref|YP_001303684.1|  L-threonine-O-3-phosphate ...   442   e-122
 gi|154494474|ref|ZP_02033794.1|  hypothetical protein PARMER...   377   e-103
 gi|53713781|ref|YP_099773.1|  aminotransferase involved in c...   254   6e-66
 gi|60682003|ref|YP_212147.1|  putative histidinol-phosphate ...   254   8e-66
 gi|34540884|ref|NP_905363.1|  L-threonine-O-3-phosphate deca...   248   4e-64
 gi|150005628|ref|YP_001300372.1|  putative histidinol-phosph...   244   7e-63
 gi|156860135|gb|EDO53566.1|  hypothetical protein BACUNI_028...   239   3e-61
 gi|124002101|ref|ZP_01686955.1|  aminotransferase involved i...   208   4e-52
 gi|91201412|emb|CAJ74472.1|  similar to L-threonine-O-3-phos...   158   5e-37


InterPro Summary:  InterProScan

InterPro
IPR004839
Domain
Aminotransferase, class I and II
PF00155 [47-335]T 1.59999889349247E-15 PF00155 Aminotran_1_2 Aminotran_1_2
InterPro
IPR015421
Domain
Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10 [29-240]T 3.59998852907816E-42 G3DSA:3.40.640.10 PyrdxlP-dep_Trfase_major_sub1 PyrdxlP-dep_Trfase_major_sub1
InterPro
IPR015424
Domain
Pyridoxal phosphate-dependent transferase, major region
SSF53383 [15-338]T 4.2E-54 SSF53383 PyrdxlP-dep_Trfase_major PyrdxlP-dep_Trfase_major
noIPR
unintegrated
unintegrated
PTHR11751 [31-342]T 1.60000240695986E-53 PTHR11751 PTHR11751 PTHR11751
PTHR11751:SF3 [31-342]T 1.60000240695986E-53 PTHR11751:SF3 PTHR11751:SF3 PTHR11751:SF3


COGS Summary:  COGS Search
BeTs to 11 clades of COG0079
COG name: Histidinol-phosphate aminotransferase
Functional Class: E
The phylogenetic pattern of COG0079 is AmtkyqvCebRH---------
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 47-282 are 26% similar to a (PYRIDOXAL PHOSPHATE AMINOTRANSFERASE TRANSFERASE PROTEIN) protein domain (PD000087 which is seen in HIS8_METJA.


Paralogs:  Local Blast Search
Residues 1-337 are 39% similar to PG1037.

Pfam Summary:  Pfam Search
Residues 56 to 339 (E-value = 5.5e-05) place PG0011 in the Aminotran_1_2 family which is described as Aminotransferase class I and II (PF00155)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
75  
92
transmembrane  
194  
211
transmembrane  
225  
244

Top PDB Hits:
-50% similar to PDB:1LC5 Crystal Structure of L-Threonine-O-3-phosphate Decarboxylase from S. enterica in its apo state (E_value = 2.1E_35);
-50% similar to PDB:1LC7 Crystal Structure of L-Threonine-O-3-phosphate Decarboxylase from S. enterica complexed with a substrate (E_value = 2.1E_35);
-50% similar to PDB:1LC8 Crystal Structure of L-Threonine-O-3-phosphate Decarboxylase from S. enterica complexed with its reaction intermediate (E_value = 2.1E_35);
-50% similar to PDB:1LKC Crystal Structure of L-Threonine-O-3-Phosphate Decarboxylase from Salmonella enterica (E_value = 2.1E_35);
-44% similar to PDB:1H1C HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (HISC) FROM THERMOTOGA MARITIMA (E_value = 7.0E_15);

Gene Protein Sequence:
MIFGHGDEGITPLSSEIVNFSTTVWTDGDKDHLEKHLVENLNCIRHYPEP
DAGTLRQMLAKRNSVDNNAILVTNGPTAAFYQIAQAFRGSRSLIAIPSFA
EYEDACRMYEHEVCFYPSNEDIGEADFSNMDFCWLCNPNNPDGRLLQRTE
ILRLLNDHPDTTFVLDQSYVSFTTEEVIRPADIKGRKNLVMVYSFSHAYG
IPGLRIGYIVANKDFMKRVAAFSTPWAVNALAIEAAKFILIHPAQFTLPI
RKWQRNTVDFITALNRLDGVEVHPSGTTFFLLRLKKGTAAELKKYMLEEY
NMLIRDASNFRGLDESYVRITTQRPAQNQLFIKALETFLEKY

Gene Nucleotide Sequence:  Sequence Viewer
ATGATTTTTGGACATGGAGATGAAGGCATTACACCCTTATCAAGCGAAAT
AGTCAATTTCAGTACCACTGTCTGGACAGATGGCGATAAAGATCATCTGG
AGAAACATCTGGTAGAAAACCTCAACTGTATTCGGCACTACCCCGAGCCG
GATGCCGGTACGCTCAGGCAGATGCTTGCCAAGCGGAACAGCGTGGACAA
TAACGCCATACTTGTAACCAACGGACCCACGGCGGCCTTCTACCAAATAG
CACAGGCTTTCAGAGGGAGCCGAAGCCTCATAGCCATTCCTTCTTTTGCC
GAATATGAGGATGCTTGTCGGATGTACGAGCACGAAGTCTGCTTCTATCC
TTCTAATGAGGACATAGGCGAGGCTGATTTTTCCAATATGGATTTCTGCT
GGCTTTGTAACCCGAACAATCCCGATGGCAGACTGCTGCAGCGGACAGAG
ATCCTGCGTCTGCTCAACGATCATCCTGACACGACATTCGTCCTCGACCA
GTCCTATGTATCGTTTACGACCGAGGAAGTGATTCGTCCGGCCGACATCA
AAGGACGGAAAAACCTTGTCATGGTCTATTCTTTCAGTCATGCCTATGGG
ATACCGGGGCTTCGCATCGGCTATATCGTAGCCAATAAAGATTTTATGAA
GCGTGTGGCGGCTTTCAGTACGCCGTGGGCGGTAAACGCACTGGCTATAG
AGGCTGCCAAATTCATCCTTATCCATCCTGCACAATTCACTCTGCCGATC
CGCAAGTGGCAACGCAATACGGTAGATTTTATCACAGCCCTGAATCGCCT
CGATGGTGTAGAAGTACATCCCTCAGGCACCACGTTCTTCCTCCTTCGCC
TCAAGAAAGGAACAGCGGCCGAACTGAAAAAATATATGCTGGAGGAATAT
AATATGCTGATTCGGGATGCTTCCAATTTCCGTGGTCTCGATGAATCCTA
CGTCCGAATCACCACGCAGCGACCTGCTCAGAACCAGCTTTTCATCAAAG
CTCTGGAGACATTCCTCGAGAAATAC

Los Alamos National Laboratory • Est 1943

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