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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0014 IGR0011 IGR0013 IGR0010 IGR0009 IGR0012 PG0012 hisC, - PG0011 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 clpC, - PG0009 nagA,ybbD, - PG0010 PG0012 hisC, - PG0011 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 clpC, - PG0009 nagA,ybbD, - PG0010 PG0012 hisC, - PG0011 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 clpC, - PG0009 nagA,ybbD, - PG0010


LANL Gene ID: PG0012

GenBank Locus Tag: PG0013

DNA Molecule Name:
1  

Genomic Island ID:
1

GenBank ID:
34539893

 Gene Name:


 Definition:
2-phosphosulfolactate phosphatase

 Cellular Location:
Cytoplasm [Evidence]

 Gene Start:
15731

Gene Stop:
16498

Gene Length:
768

Molecular Weight*:
28042

pI*:
5.20

Net Charge*:
-5.31

EC:
3.1.3.71  

 Functional Class:
Unknown; Conserved hypothetical  

 Gene Ontology:
Biological process
  GO:0019295    coenzyme M biosynthetic process

Molecular function
  GO:0000287    magnesium ion binding
  GO:0050532    2-phosphosulfolactate phosphatase activity


 Pathway: pathway table

 Comment:
TIGR ID: PG0013

 Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
A few significant hits in gapped BLAST to conserved proteins; e.g. residues 24-232 are 35% similar to a conserved hypothetical protein of Thermotoga maritima (AE001747), residues 26-248 are 30% similar to a conserved hypothetical protein of Deinococcus radiodurans (AE001985), residues 26-166 are 39% similar to a conserved protein of Methanobacterium thermoautotrophicum (AE000887).

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539893|ref|NP_904372.1|  hypothetical protein PG0013 [P...   520   e-146
 gi|154494997|ref|ZP_02034002.1|  hypothetical protein PARMER...   224   3e-57
 gi|149277084|ref|ZP_01883226.1|  hypothetical protein PBAL39...   148   3e-34
 gi|124003959|ref|ZP_01688806.1|  2-phosphosulfolactate phosp...   146   1e-33
 gi|110639204|ref|YP_679413.1|  conserved hypothetical protei...   136   1e-30
 gi|126648154|ref|ZP_01720648.1|  2-phosphosulfolactate phosp...   135   2e-30
 gi|148381493|ref|YP_001256034.1|  2-phosphosulfolactate phos...   131   5e-29
 gi|153933558|ref|YP_001385868.1|  putative 2-phosphosulfolac...   131   5e-29
 gi|153939295|ref|YP_001392907.1|  putative 2-phosphosulfolac...   130   5e-29
 gi|110801862|ref|YP_699809.1|  2-phosphosulfolactate phospha...   128   3e-28


InterPro Summary:  InterProScan

InterPro
IPR005238
Family
2-phosphosulfolactate phosphatase
PF04029 [3-239]T 1.7999975402237802E-38 PF04029 2-ph_phosp 2-ph_phosp
noIPR
unintegrated
unintegrated
G3DSA:3.90.1560.10 [12-232]T 3.70001063537236E-57 G3DSA:3.90.1560.10 G3DSA:3.90.1560.10 G3DSA:3.90.1560.10


COGS Summary:  COGS Search
BeTs to 5 clades of COG2045
COG name: Uncharacterized ACR
Functional Class: S
The phylogenetic pattern of COG2045 is -mt---vc-b-----------
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 26-230 are 32% similar to a (PROTEIN YITC CONSERVED MJ1140) protein domain (PD017220 which is seen in P73849_SYNY3.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 3 to 239 (E-value = 1.6e-41) place PG0012 in the 2-ph_phosp family which is described as 2-phosphosulpholactate phosphatase (PF04029)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
35  
52
transmembrane  
108  
124
transmembrane  
113  
130

Top PDB Hits:
-55% similar to PDB:1VR0 Crystal structure of putative 2-phosphosulfolactate phosphatase (15026306) from Clostridium acetobutylicum at 2.6 A resolution (E_value = 4.8E_28);
-56% similar to PDB:1NV8 N5-glutamine methyltransferase, HemK (E_value = 4.8E_28);
-56% similar to PDB:1NV9 HemK, apo structure (E_value = 4.8E_28);
-56% similar to PDB:1SG9 Crystal structure of hypothetical protein HEMK (E_value = 4.8E_28);
-56% similar to PDB:1VQ1 Crystal structure of N5-glutamine methyltransferase, HemK(EC 2.1.1.-) (TM0488) from Thermotoga maritima at 2.80 A resolution (E_value = 4.8E_28);

Gene Protein Sequence:
MLQISLCPSPVLYPYYKTEQEEYTVVIVDIFRAGTTITTALMNGAVGIIP
IATVEEAEIYAGNGFLVGGERGTKRLPFAHFGNAPEEYTRQAVEGKQLVL
STTNGTRAADIVAGALHVIIGAFINLEAVARYCIAKQKPVMVLASGWQNR
MSTEDCLFAGALAATIVRLGEEVICEDGASVFQELWGNYNTHEKLMAYLN
GRDHYERLRANKLERSVPYCTSLNLTEIVPELTFKISAASTDCPANRLFL
PVTPPF

Gene Nucleotide Sequence:  Sequence Viewer
ATGCTGCAGATCAGTCTCTGTCCTTCTCCTGTACTCTATCCATATTACAA
GACGGAGCAAGAAGAGTACACGGTTGTTATCGTGGATATCTTCCGTGCCG
GTACCACCATCACAACGGCACTGATGAACGGTGCCGTAGGCATCATCCCG
ATTGCAACCGTTGAGGAGGCGGAAATCTATGCCGGGAACGGGTTCCTCGT
AGGAGGCGAGCGAGGAACGAAGCGATTGCCTTTCGCTCATTTCGGCAATG
CTCCCGAAGAGTACACTCGCCAGGCGGTAGAGGGGAAACAGCTCGTACTA
TCGACGACCAACGGTACCCGCGCTGCCGACATAGTTGCCGGAGCCTTGCA
CGTTATTATCGGGGCTTTTATCAATCTGGAAGCTGTCGCTCGCTATTGTA
TCGCCAAGCAGAAGCCGGTCATGGTACTGGCTTCGGGCTGGCAAAACAGG
ATGAGTACGGAGGATTGTCTGTTCGCCGGTGCTTTGGCTGCTACGATTGT
CCGGCTTGGAGAGGAGGTCATTTGCGAAGACGGAGCGTCAGTTTTCCAAG
AACTCTGGGGTAACTACAATACGCATGAGAAGCTGATGGCCTACCTGAAC
GGTCGCGATCATTACGAACGCCTGCGCGCCAATAAATTGGAAAGAAGTGT
TCCCTATTGCACTTCACTCAATCTCACAGAAATTGTTCCCGAACTGACCT
TCAAAATTTCTGCCGCATCAACGGATTGCCCGGCTAACCGACTCTTCTTA
CCCGTCACTCCACCTTTC

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