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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0014 IGR0011 IGR0013 IGR0010 IGR0015 IGR0016 IGR0012 PG0017 PG0012 hisC, - PG0011 ISPg4, - PG0016 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 nagA,ybbD, - PG0010 PG0017 PG0012 hisC, - PG0011 ISPg4, - PG0016 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 nagA,ybbD, - PG0010 Type: IS element, Name: ISPg4 - 7 PG0017 PG0012 hisC, - PG0011 ISPg4, - PG0016 atoS,ntrB, - PG0014 ntrC, - PG0013 PG0015 nagA,ybbD, - PG0010


LANL Gene ID: PG0014

GenBank Locus Tag: PG0017

DNA Molecule Name:
1  

Genomic Island ID:
1

GenBank ID:
34539895

 Gene Name:
atoS  ntrB  

 Definition:
two-component sensor histidine kinase

 Cellular Location:
Inner membrane, Cytoplasm [Evidence]

 Gene Start:
18447

Gene Stop:
19781

Gene Length:
1335

Molecular Weight*:
50052

pI*:
6.70

Net Charge*:
-1.88

EC:
2.7.3.-  

 Functional Class:
Regulatory functions  

 Gene Ontology:
Biological process
  GO:0007165    signal transduction
  GO:0016310    phosphorylation
  GO:0018106    peptidyl-histidine phosphorylation

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0000155    two-component sensor activity
  GO:0004673    protein histidine kinase activity
  GO:0005524    ATP binding
  GO:0016772    transferase activity, transferring phosphorus-containing groups


 Pathway: pathway table

 Comment:
TIGR ID: PG0017

 Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significiant hits in gapped BLAST to histidine kinase
sensor proteins; e.g. residues 66-435 are 26% similar to the nitrogen regulation protein NtrY of Neisseria meningitidis (AE002370), residues 116-441 are 27% similar to the 2-component regulatory system-sensor histidine kinase in Chlamydia trachomatis (AE001320), residues 76-444 are 26% similar to the sensor histidine kinase in Thermotoga maritima (AE001790).

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539895|ref|NP_904374.1|  sensor histidine kinase [Porph...   833   0.0  
 gi|156861044|gb|EDO54475.1|  hypothetical protein BACUNI_019...   269   3e-70
 gi|156110147|gb|EDO11892.1|  hypothetical protein BACOVA_023...   261   6e-68
 gi|150008023|ref|YP_001302766.1|  putative two-component sys...   260   1e-67
 gi|154492707|ref|ZP_02032333.1|  hypothetical protein PARMER...   259   2e-67
 gi|53713438|ref|YP_099430.1|  putative two-component system ...   259   2e-67
 gi|29346099|ref|NP_809602.1|  putative two-component system ...   259   3e-67
 gi|60681685|ref|YP_211829.1|  putative two-component system,...   258   5e-67
 gi|153806550|ref|ZP_01959218.1|  hypothetical protein BACCAC...   245   3e-63
 gi|150005965|ref|YP_001300709.1|  putative two-component sys...   245   5e-63


InterPro Summary:  InterProScan

InterPro
IPR003594
Domain
ATP-binding region, ATPase-like
G3DSA:3.30.565.10 [288-445]T 2.4999981195644396E-25 G3DSA:3.30.565.10 ATP_bd_ATPase ATP_bd_ATPase
PF02518 [332-445]T 8.400017031637291E-22 PF02518 HATPase_c HATPase_c
SM00387 [332-445]T 1.19999999999993E-19 SM00387 HATPase_c HATPase_c
SSF55874 [292-444]T 3.0000000000000006E-32 SSF55874 ATP_bd_ATPase ATP_bd_ATPase
InterPro
IPR003661
Domain
Histidine kinase A, N-terminal
SM00388 [221-290]T 1.7 SM00388 HisKA HisKA
InterPro
IPR004358
Domain
Histidine kinase related protein, C-terminal
PR00344 [378-392]T 2.9E-12 PR00344 BCTRLSENSOR[396-406]T 2.9E-12 PR00344 BCTRLSENSOR[407-425]T 2.9E-12 PR00344 BCTRLSENSOR[431-444]T 2.9E-12 PR00344 BCTRLSENSOR BCTRLSENSOR
InterPro
IPR005467
Domain
Histidine kinase
PS50109 [228-445]T 0.0 PS50109 HIS_KIN HIS_KIN
noIPR
unintegrated
unintegrated
PTHR23283 [115-445]T 7.099983251124779E-40 PTHR23283 PTHR23283 PTHR23283
PTHR23283:SF24 [115-445]T 7.099983251124779E-40 PTHR23283:SF24 PTHR23283:SF24 PTHR23283:SF24
SSF55785 [109-204]T 2.5E-6 SSF55785 SSF55785 SSF55785


COGS Summary:  COGS Search
BeTs to 12 clades of COG0642
COG name: Sensory transduction histidine kinases
Functional Class: T
The phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inX
Number of proteins in this genome belonging to this COG is 6
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 314-444 are 35% similar to a (KINASE PROTEIN SENSORY TRANSDUCTION HISTIDINE SENSOR) protein domain (PD000064 which is seen in Q50903_MYXXA.


Paralogs:  Local Blast Search
Residues 64-444 are 25% similar to PG0674 and residues 213-444 are 22% similar to PG0045.

Pfam Summary:  Pfam Search
Residues 332 to 445 (E-value = 1.6e-21) place PG0014 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable signal  
1  
29
transmembrane  
16  
40
transmembrane  
33  
49
transmembrane  
112  
128
transmembrane  
119  
136

Top PDB Hits:
-46% similar to PDB:2C2A STRUCTURE OF THE ENTIRE CYTOPLASMIC PORTION OF A SENSOR HISTIDINE KINASE PROTEIN (E_value = 2.9E_11);
-54% similar to PDB:1R62 Crystal structure of the C-terminal Domain of the Two-Component System Transmitter Protein NRII (NtrB) (E_value = 7.1E_10);

Gene Protein Sequence:
MGRRKTGSFGLHLLFTIVMAVVGTWSAAAGHYAITVFAAGLVIFSALRLR
LLYRRHLQDLSLLLNAIENGDYSVRFSEMGGNVSHRTFNRTLNRIKEILS
RSRDEAIAGEQFLVHVLEQIPVGIMMVAPEGYVYSTNTVLLRLLGLPVIT
HLDQLRRVSPDMPRLFRSAATDSGIHIKLTTEREEQEVSLRFSSFRIRGK
IYHIYTLSNIGKELDARETESWIRLIRVMTHEIMNSIAPITSICDTLLDN
LQSSADEEMLSTGLDTIRSTGVGLLSFVQDYRKFTAVPPPEKEDIALHAF
LSGILRLQEELLSSNDIKVDIEEIPVELTVPADRRQLTSVLINLVKNAAE
AEYPADTEKRLLRIRVEERLDSLDEHRLLLHVENNGTPIPQEVFDNMFVP
FYTTKTGGSGIGLSLSRYIIRLHGGNLLARRTADGFTSFVIELPL

Gene Nucleotide Sequence:  Sequence Viewer
ATGGGAAGACGGAAGACCGGCAGTTTCGGCTTGCATCTGTTATTTACCAT
CGTCATGGCGGTGGTGGGTACTTGGTCGGCAGCTGCAGGACATTATGCCA
TCACTGTTTTTGCAGCCGGACTCGTTATCTTTTCCGCCTTGCGGTTGCGT
TTACTTTATCGGCGCCATCTTCAAGATCTTTCCCTGCTCTTGAATGCTAT
CGAGAATGGCGATTATTCCGTGCGCTTTTCCGAAATGGGAGGCAATGTCT
CGCATCGAACATTCAACCGCACGCTTAATCGTATCAAGGAGATCCTCAGC
CGTTCTCGTGATGAGGCTATAGCCGGCGAGCAGTTTCTCGTACATGTATT
GGAACAGATTCCTGTCGGCATCATGATGGTTGCTCCGGAAGGATATGTCT
ATTCTACCAATACAGTGCTGTTGCGCCTCCTCGGTTTACCCGTTATCACA
CACCTCGATCAGCTCAGACGTGTGTCGCCGGACATGCCTCGACTGTTTCG
TTCGGCGGCTACCGATTCAGGTATTCATATCAAGCTTACTACGGAGCGGG
AAGAGCAGGAGGTGAGCCTCCGCTTCTCTTCGTTCCGCATCAGGGGGAAG
ATATACCATATATATACGCTGTCGAATATCGGCAAGGAGCTTGACGCTCG
CGAGACAGAGTCGTGGATTCGGCTCATTCGGGTGATGACGCACGAGATCA
TGAACTCGATAGCCCCCATTACTTCGATATGCGATACCCTCTTGGACAAT
TTGCAAAGCTCTGCGGACGAGGAGATGCTGTCTACCGGATTGGATACCAT
TCGTAGTACCGGAGTGGGGCTGTTATCCTTTGTACAGGACTACCGTAAGT
TTACGGCAGTTCCTCCTCCCGAGAAGGAGGACATTGCTTTACATGCTTTT
CTTTCGGGGATATTGCGCCTGCAAGAAGAGCTTCTGTCCTCCAACGATAT
AAAGGTGGATATTGAAGAAATACCCGTGGAGCTGACTGTCCCGGCCGACC
GCCGGCAATTGACTTCGGTACTGATAAACCTCGTCAAAAATGCTGCCGAG
GCGGAATATCCTGCCGATACGGAGAAACGACTTTTGCGTATTCGTGTCGA
GGAACGTCTCGATTCGTTGGATGAACACAGACTACTCCTTCATGTGGAGA
ACAATGGCACTCCTATTCCTCAAGAGGTGTTCGACAATATGTTTGTTCCT
TTCTATACGACCAAAACCGGAGGTAGCGGCATCGGTCTGAGCCTTTCCCG
TTATATCATTCGTCTGCATGGGGGAAATTTGCTTGCGAGGCGTACAGCCG
ATGGTTTCACCTCTTTCGTTATTGAACTGCCGCTC

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