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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0017 IGR0019 IGR0021 IGR0020 IGR0016 IGR0018 PG0018 ychM, - PG0019 PG0019.1 PG0020 PG0021 PG0017 ISPg4, - PG0016 PG0023 PG0022 PG0018 ychM, - PG0019 PG0019.1 PG0020 PG0021 PG0017 ISPg4, - PG0016 PG0023 PG0022 Type: IS element, Name: ISPg4 - 7 PG0018 ychM, - PG0019 PG0019.1 PG0020 PG0021 ISPg4, - PG0016 PG0023 PG0022 PG0017


LANL Gene ID: PG0020

GenBank Locus Tag: PG0024

DNA Molecule Name:
1  

GenBank ID:
34539901

Gene Name:


Definition:
conserved hypothetical protein (possible DNA binding protein)

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
27872

Gene Stop:
28525

Gene Length:
654

Molecular Weight*:
23916

pI*:
7.60

Net Charge*:
1.34

EC:
 

Functional Class:
Unknown; Conserved hypothetical  

Gene Ontology:
Biological process
  GO:0006980    redox signal response
  GO:0016481    negative regulation of transcription

Cellular component
  GO:0005737    cytoplasm

Molecular function
  GO:0016564    transcriptional repressor activity


Pathway: pathway table

Comment:
TIGR ID: PG0024

Proteomic Data: Proteomic Data Search
TIGR AnnotationDNA-binding protein, putative, GroupT (unknown function)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0024-1.560.072-6.250.0051-6.250.0051
LANLPG00200.340.01
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous hits in gapped BLAST to conserved hypothetical proteins; e.g. residues 15-210 are 35% similar to a DNA-binding protein in Streptomyces coelicolor (AL079345), residues 13-207 are 34% similar to the ydiH protein in Bacillus subtilis (D88802), residues 13-218 are 33% similar to the YdiH in Bacillus halodurans (AB013375).

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539901|ref|NP_904380.1|  redox-sensing transcriptional ...   441   e-122
 gi|53715292|ref|YP_101284.1|  redox-sensing transcriptional ...   280   4e-74
 gi|60683227|ref|YP_213371.1|  redox-sensing transcriptional ...   280   4e-74
 gi|29349290|ref|NP_812793.1|  redox-sensing transcriptional ...   278   2e-73
 gi|156859600|gb|EDO53031.1|  hypothetical protein BACUNI_030...   277   3e-73
 gi|156111360|gb|EDO13105.1|  hypothetical protein BACOVA_011...   273   4e-72
 gi|153809101|ref|ZP_01961769.1|  hypothetical protein BACCAC...   272   1e-71
 gi|150004196|ref|YP_001298940.1|  putative DNA binding prote...   271   2e-71
 gi|154494063|ref|ZP_02033383.1|  hypothetical protein PARMER...   263   4e-69
 gi|150009176|ref|YP_001303919.1|  putative DNA binding prote...   256   5e-67


InterPro Summary:  InterProScan

InterPro
IPR003781
Domain
CoA-binding
PF02629 [88-192]T 1.99999636034536E-24 PF02629 CoA_binding CoA_binding
InterPro
IPR009718
Domain
Rex DNA-binding, C-terminal
PF06971 [13-62]T 1.29999924468183E-19 PF06971 Put_DNA-bind_N Put_DNA-bind_N
InterPro
IPR011991
Domain
Winged helix repressor DNA-binding
G3DSA:1.10.10.10 [13-85]T 9.800002721303039E-19 G3DSA:1.10.10.10 Wing_hlx_DNA_bd Wing_hlx_DNA_bd
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.720 [86-216]T 1.49999648196318E-38 G3DSA:3.40.50.720 G3DSA:3.40.50.720 G3DSA:3.40.50.720
SSF46785 [16-89]T 3.6E-20 SSF46785 SSF46785 SSF46785
SSF51735 [94-217]T 7.5E-32 SSF51735 SSF51735 SSF51735


COGS Summary:  COGS Search
No hit to the COGs database.
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 13-207 are 34% similar to a (PROTEIN YDIH) protein domain (PD112016 which is seen in O05521_BACSU.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 183 to 214 (E-value = 1.4e-12) place PG0020 in the Put_DNA-bind_C family which is described as Putative DNA-binding protein C-terminus (PF06971)

 Structural Feature(s):
Feature Type  Start  Stop
non-globular  
1  
114

Top PDB Hits:
-49% similar to PDB:1XCB X-ray Structure of a Rex-Family Repressor/NADH Complex from Thermus Aquaticus (E_value = 9.6E_24);
-49% similar to PDB:2DT5 Crystal Structure of TTHA1657 (AT-rich DNA-binding protein) from Thermus thermophilus HB8 (E_value = 1.6E_23);
-35% similar to PDB:1DJ9 CRYSTAL STRUCTURE OF 8-AMINO-7-OXONANOATE SYNTHASE (OR 7-KETO-8AMINIPELARGONATE OR KAPA SYNTHASE) COMPLEXED WITH PLP AND THE PRODUCT 8(S)-AMINO-7-OXONANONOATE (OR KAPA). THE ENZYME OF BIOTIN BIOSYNTHETIC PATHWAY. (E_value = 1.6E_23);
-35% similar to PDB:1DJE CRYSTAL STRUCTURE OF THE PLP-BOUND FORM OF 8-AMINO-7-OXONANOATE SYNTHASE (E_value = 1.6E_23);
-48% similar to PDB:1Y81 Conserved hypothetical protein Pfu-723267-001 from Pyrococcus furiosus (E_value = 1.6E_23);

Gene Protein Sequence:
MKTIANESFLLDTKVPEPTLRRLPWYLSYVQLLHADGCESVSSTRIARAV
GVDASLVAKDLSYVSVDGRTRVGYRVADMVAVLNDFLGFTHHHRAFLFGV
GSLGAALLQDSGLRHFGLEIAAGFDVNPDIVDTNINGIPVYHKSRVAELC
ARERVDIGILTVPIRAAQSMADEMIAAGIKAIWNFTPWRISVPEGVVVQN
TSMYAQLAVMFNRMKSLP

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAACGATTGCGAACGAGTCTTTTCTTCTTGATACAAAAGTCCCCGA
ACCTACTCTGAGGCGTCTTCCCTGGTATTTGTCTTACGTCCAGCTTTTGC
ATGCGGATGGATGCGAGTCGGTGTCTTCCACGCGGATCGCTCGTGCCGTA
GGAGTGGATGCTTCGCTCGTGGCCAAGGATCTCTCCTATGTATCGGTGGA
TGGGCGTACACGGGTAGGGTACCGGGTGGCGGACATGGTGGCTGTGCTGA
ACGACTTTCTGGGCTTTACGCACCACCACCGTGCTTTCCTCTTCGGGGTG
GGAAGTCTGGGTGCTGCTTTGTTGCAGGACTCGGGTTTGCGCCACTTCGG
GTTGGAGATTGCCGCCGGGTTCGATGTGAATCCGGATATTGTGGACACTA
ATATCAATGGCATCCCCGTTTACCATAAGAGCCGGGTTGCGGAGTTGTGC
GCTCGAGAGCGTGTGGATATAGGTATTCTTACCGTTCCGATACGGGCGGC
ACAGTCGATGGCCGATGAGATGATAGCAGCAGGGATCAAGGCTATTTGGA
ATTTTACCCCTTGGCGCATCAGTGTACCCGAAGGCGTGGTCGTACAGAAT
ACGTCGATGTATGCCCAGTTGGCTGTGATGTTCAATCGGATGAAATCGCT
ACCT

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