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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0017 IGR0019 IGR0021 IGR0020 IGR0018 PG0018 ychM, - PG0019 PG0019.1 PG0020 PG0021 PG0017 PG0023 PG0022 PG0018 ychM, - PG0019 PG0019.1 PG0020 PG0021 PG0017 PG0023 PG0022 PG0018 ychM, - PG0019 PG0019.1 PG0020 PG0021 PG0017 PG0023 PG0022


LANL Gene ID: PG0021

GenBank Locus Tag: PG0025

DNA Molecule Name:
1  

GenBank ID:
34539902

Gene Name:


Definition:
isomerase/hydrolase protein

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
28597

Gene Stop:
29253

Gene Length:
657

Molecular Weight*:
24482

pI*:
7.10

Net Charge*:
0.31

EC:
 

Functional Class:
Uncategorized  

Gene Ontology:
Biological process
  GO:0008152    metabolic process

Molecular function
  GO:0003824    catalytic activity


Pathway: pathway table

Comment:
TIGR ID: PG0025

Proteomic Data: Proteomic Data Search
TIGR Annotationfumarylacetoacetate hydrolase family protein, GroupH (energy metabolism)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0025-0.060.240.010.250.640.170.010.25
LANLPG00210.961.011.561.17
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST to isomerase proteins; e.g. residues 2-213 are 36% similar to a putative isomerase in Escherichia coli (AE000216), residues 2-206 are 39% similar to an isomerase-like protein in Arabidopsis thaliana (Z97340), residues 2-209 are 36% similar to a 230aa long hypothetical 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase in Pyrococcus horikoshii (AP000003).

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539902|ref|NP_904381.1|  fumarylacetoacetate hydrolase ...   454   e-126
 gi|154494062|ref|ZP_02033382.1|  hypothetical protein PARMER...   266   6e-70
 gi|150009175|ref|YP_001303918.1|  putative hydrolase [Paraba...   266   8e-70
 gi|150004197|ref|YP_001298941.1|  2-hydroxyhepta-2,4-diene-1...   261   2e-68
 gi|60683226|ref|YP_213370.1|  putative hydrolase [Bacteroide...   261   3e-68
 gi|53715291|ref|YP_101283.1|  2-hydroxyhepta-2,4-diene-1,7-d...   260   4e-68
 gi|156859601|gb|EDO53032.1|  hypothetical protein BACUNI_030...   250   5e-65
 gi|153809102|ref|ZP_01961770.1|  hypothetical protein BACCAC...   249   9e-65
 gi|29349291|ref|NP_812794.1|  2-hydroxyhepta-2,4-diene-1,7-d...   246   5e-64
 gi|156111361|gb|EDO13106.1|  hypothetical protein BACOVA_011...   241   2e-62


InterPro Summary:  InterProScan

InterPro
IPR002529
Domain
Fumarylacetoacetate (FAA) hydrolase
PF01557 [30-200]T 5.7999965385478095E-31 PF01557 FAA_hydrolase FAA_hydrolase
noIPR
unintegrated
unintegrated
G3DSA:3.90.850.10 [2-214]T 4.3999900123769395E-55 G3DSA:3.90.850.10 G3DSA:3.90.850.10 G3DSA:3.90.850.10
PTHR11820 [2-19]T 1.30000495407324E-67 PTHR11820 PTHR11820[39-219]T 1.30000495407324E-67 PTHR11820 PTHR11820 PTHR11820
PTHR11820:SF7 [2-19]T 1.30000495407324E-67 PTHR11820:SF7 PTHR11820:SF7[39-219]T 1.30000495407324E-67 PTHR11820:SF7 PTHR11820:SF7 PTHR11820:SF7
SSF56529 [1-219]T 2.6000000000000003E-51 SSF56529 SSF56529 SSF56529


COGS Summary:  COGS Search
BeTs to 9 clades of COG0179
COG name: 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
Functional Class: R
The phylogenetic pattern of COG0179 is Amtky--cEbR----------
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** PF01557 (Fumarylacetoacetate (FAA) hydrolase family) with a combined E-value of 7.7e-18.
    PF01557B    83-117
    PF01557C    180-194


 ProDom Summary:  Protein Domain Search
Residues 39-204 are 39% similar to a (ISOMERASE PROTEIN 7-DIOATE 2-HYDROXYHEPTA-2 4-DIENE-1) protein domain (PD002459 which is seen in P76004_ECOLI.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 30 to 200 (E-value = 3.1e-34) place PG0021 in the FAA_hydrolase family which is described as Fumarylacetoacetate (FAA) hydrolase family (PF01557)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-53% similar to PDB:1SAW X-ray structure of homo sapiens protein FLJ36880 (E_value = 9.6E_32);
-49% similar to PDB:1NR9 Crystal Structure of Escherichia coli 1262 (APC5008), Putative Isomerase (E_value = 6.2E_31);
-51% similar to PDB:2DFU Crystal structure of the 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from Thermus Thermophilus HB8 (E_value = 1.3E_25);
-45% similar to PDB:1NKQ Crystal Structure of Yeast Hypothetical Protein YNQ8_YEAST (E_value = 1.2E_18);
-47% similar to PDB:1GTT CRYSTAL STRUCTURE OF HPCE (E_value = 2.1E_18);

Gene Protein Sequence:
MKIIAVGMNYGAHVSEMRRADILPVAPCPDGGGADFCVEEPVLFLKADSL
LREGHPLFYPDFSQEIHYETELVVRIDRIGKCIAERFAHRYYSEVTVGID
FTARDLQRRAKAKGLPWATAKAFDNSAAVGRWVKKDSLRHGVQELGLRLD
IDGRTVQQGNTRDMLFSVDRLIAYASRFFTLRMGDLIFTGTPAGVGPIAI
GQHLEAYLEEQKLLDISIK

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAGATAATTGCTGTCGGCATGAACTATGGTGCGCATGTCAGCGAAAT
GCGACGTGCGGACATCCTTCCCGTTGCTCCCTGTCCGGATGGAGGGGGAG
CCGATTTTTGTGTGGAGGAACCTGTGCTTTTCCTCAAGGCCGACTCCTTG
TTGCGCGAAGGGCATCCCCTTTTCTATCCGGATTTTTCTCAGGAGATCCA
CTATGAGACGGAGCTGGTGGTTCGTATAGATCGTATCGGCAAGTGCATAG
CCGAACGTTTTGCTCACCGCTATTACAGTGAGGTTACTGTCGGTATAGAC
TTCACGGCTCGTGACCTCCAGCGTCGTGCCAAAGCCAAGGGGTTGCCCTG
GGCAACGGCCAAAGCTTTCGACAACTCCGCTGCCGTAGGGCGGTGGGTGA
AAAAAGACTCGCTCCGGCACGGTGTGCAGGAATTGGGCCTGCGATTGGAT
ATAGACGGACGCACGGTGCAGCAGGGCAATACACGGGATATGCTCTTTTC
CGTAGATCGTTTGATCGCTTATGCCAGTCGTTTCTTCACACTTCGTATGG
GGGATCTTATCTTTACAGGGACTCCGGCAGGGGTAGGCCCCATTGCTATC
GGGCAGCACCTCGAAGCCTATCTCGAAGAGCAAAAACTGCTCGACATATC
CATCAAA

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