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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0028 IGR0027 IGR0030 IGR0031 IGR0029 IGR0032 trxA, - PG0030 PG0027 PG0029 PG0028 dnaE, - PG0031 rl19, - PG0032 trxA, - PG0030 PG0027 PG0029 PG0028 dnaE, - PG0031 rl19, - PG0032 trxA, - PG0030 PG0027 PG0029 PG0028 dnaE, - PG0031 rl19, - PG0032


LANL Gene ID: PG0030

GenBank Locus Tag: PG0034

DNA Molecule Name:
1  

GenBank ID:
34539910

Gene Name:
trxA  

Definition:
thioredoxin

Cellular Location:
Cytoplasm, Periplasm [Evidence]

Gene Start:
42639

Gene Stop:
42328

Gene Length:
312

Molecular Weight*:
11416

pI*:
4.70

Net Charge*:
-3.10

EC:
 

Functional Class:
Energy metabolism; Electron transport  

Gene Ontology:
Biological process
  GO:0006662    glycerol ether metabolic process
  GO:0045454    cell redox homeostasis

Molecular function
  GO:0009055    electron carrier activity
  GO:0015035    protein disulfide oxidoreductase activity


Pathway: pathway table

Comment:
Thioredoxin (TRX) is involved in several redox
reactions. See Rockey et al. Microbiol. 142:945
(1996). See CT099.

From Prosite PDOC00172:

Thioredoxins are small proteins of approximately
one hundred amino-acid residues which participate
in various redox reactions via the reversible
oxidation of an active center disulfide bond. They
exist in either a reduced form or an oxidized form
where the two cysteine residues are linked in an
intramolecular disulfide bond. Thioredoxin is
present in prokaryotes and eukaryotes and the
sequence around the redox-active disulfide bond is
well conserved. Bacteriophage T4 also encodes for
a thioredoxin but its primary structure is not
homologous to bacterial, plant and vertebrate
thioredoxins.

TIGR ID: PG0034

Proteomic Data: Proteomic Data Search
TIGR Annotationthioredoxin, GroupH (energy metabolism)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG00340.070.190.170.20.813.3e-080.170.2
LANLPG00301.051.121.761.46
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST to thioredoxin proteins; e.g. residues 3-103 are 51% similar to the thioredoxin (trxA) of Helicobacter pylori 26695 (AE000594), residues 3-101 are 50% similar to the thioredoxin of Staphylococcus aureus (AJ223480), residues 3-102 are 50% similar to the thioredoxin of Escherichia coli (K02845).

This sequence is similar to CT539 of Chlamydia trachomatis.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539910|ref|NP_904389.1|  thioredoxin [Porphyromonas gin...   207   1e-52
 gi|154491986|ref|ZP_02031612.1|  hypothetical protein PARMER...   145   7e-34
 gi|156109486|gb|EDO11231.1|  hypothetical protein BACOVA_031...   142   6e-33
 gi|150010064|ref|YP_001304807.1|  thioredoxin [Parabacteroid...   141   1e-32
 gi|53712002|ref|YP_097994.1|  thioredoxin [Bacteroides fragi...   140   2e-32
 gi|156859510|gb|EDO52941.1|  hypothetical protein BACUNI_037...   140   3e-32
 gi|86134260|ref|ZP_01052842.1|  thioredoxin [Tenacibaculum s...   140   3e-32
 gi|88711233|ref|ZP_01105321.1|  thioredoxin [Flavobacteriale...   139   4e-32
 gi|126663021|ref|ZP_01734019.1|  thioredoxin [Flavobacteria ...   139   6e-32
 gi|88801398|ref|ZP_01116926.1|  thioredoxin M [Polaribacter ...   138   1e-31


InterPro Summary:  InterProScan

InterPro
IPR005746
Family
Thioredoxin
TIGR01068 [5-104]T 1.4104510690792002E-52 TIGR01068 thioredoxin thioredoxin
InterPro
IPR006662
Domain
Thioredoxin-related
PR00421 [20-28]T 1.1E-9 PR00421 THIOREDOXIN[28-37]T 1.1E-9 PR00421 THIOREDOXIN[68-79]T 1.1E-9 PR00421 THIOREDOXIN THIOREDOXIN
PS00194 [21-39]T 8.0E-5 PS00194 THIOREDOXIN THIOREDOXIN
InterPro
IPR012335
Domain
Thioredoxin fold
G3DSA:3.40.30.10 [3-104]T 2.19999900980727E-32 G3DSA:3.40.30.10 Thioredoxin_fold Thioredoxin_fold
InterPro
IPR012336
Domain
Thioredoxin-like fold
SSF52833 [1-104]T 6.9E-36 SSF52833 IPR012336 IPR012336
InterPro
IPR013766
Domain
Thioredoxin domain
PF00085 [1-103]T 1.70000295590065E-39 PF00085 Thioredoxin Thioredoxin
InterPro
IPR015467
Domain
Thioredoxin family
PTHR10438 [18-104]T 1.70000295590065E-39 PTHR10438 Trx Trx
noIPR
unintegrated
unintegrated
PTHR10438:SF13 [18-104]T 1.70000295590065E-39 PTHR10438:SF13 PTHR10438:SF13 PTHR10438:SF13


COGS Summary:  COGS Search
BeTs to 15 clades of COG0526
COG name: Thiol-disulfide isomerase and thioredoxins
Functional Class: O,C
The phylogenetic pattern of COG0526 is AMTkYQVCEBRHUJgpoLINX
Number of proteins in this genome belonging to this COG is 7
Blocks Summary:  Blocks Search
***** IPB000063 (Thioredoxin family) with a combined E-value of 3.4e-10.
    IPB000063    21-33


 ProDom Summary:  Protein Domain Search
Residues 3-69 are 55% similar to a (REDOX-ACTIVE CENTER PROTEIN ISOMERASE PRECURSOR) protein domain (PD000175 which is seen in Q9ZEH4_STAAU.

Residues 5-90 are 31% similar to a (PROTEIN THIOREDOXIN PUTATIVE INTERGENIC) protein domain (PD012637 which is seen in Q9ZPH2_ARATH.


Paralogs:  Local Blast Search
Residues 18-78 are 49% similar to PG0246, thioredoxin. Residues 14-348 are 33% similar to PG1431, cytochrome c biogenesis protein and residues 14-362 are 31% similar to PG0966, a probable cytochrome c biogenesis protein.

Pfam Summary:  Pfam Search
Residues 1 to 104 (E-value = 1.9e-38) place PG0030 in the Thioredoxin family which is described as Thioredoxin (PF00085)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-69% similar to PDB:1ZZY Crystal Structure of Thioredoxin Mutant L7V (E_value = 1.4E_24);
-70% similar to PDB:2FCH Crystal Structure of Thioredoxin Mutant G74S (E_value = 1.4E_24);
-69% similar to PDB:1SKR T7 DNA Polymerase Complexed To DNA Primer/Template and ddATP (E_value = 1.9E_24);
-69% similar to PDB:1SKS Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine dimer on the template (E_value = 1.9E_24);
-69% similar to PDB:1SKW Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template (E_value = 1.9E_24);

Gene Protein Sequence:
MALQITDATFDGLVAEGKPMVVDFWATWCGPCRMVGPIIDELAAEYEGRA
IIGKVDVDANTELPMKYGVRNIPTILFIKNGEVVKKLVGAQSKDVFKKEL
DALF

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCACTGCAAATTACAGATGCAACATTTGACGGCTTGGTAGCTGAAGG
CAAGCCGATGGTAGTGGATTTCTGGGCTACATGGTGCGGTCCTTGCCGCA
TGGTAGGTCCGATCATCGACGAGCTGGCTGCGGAATATGAAGGACGCGCT
ATCATAGGAAAAGTGGATGTGGATGCAAATACGGAATTGCCCATGAAGTA
TGGCGTGCGTAATATCCCCACCATTTTGTTCATCAAGAACGGCGAAGTGG
TAAAGAAGCTCGTGGGTGCTCAGTCCAAAGACGTATTCAAGAAAGAATTG
GATGCCTTGTTT

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