Search Results

Record: 1 of 1 MiniMap

LANL Gene ID: PG0038GenBank Locus Tag: PG0045DNA Molecule Name: 1 Genomic Island ID: 20 GenBank ID: 34539918 Gene Name: htpG Definition: heat shock protein, HSP90 family Cellular Location: Cytoplasm [Evidence] Gene Start: 54199 Gene Stop: 56250 Gene Length: 2052 Molecular Weight*: 78212 pI*: 4.90 Net Charge*: -28.65 EC: Functional Class: Cellular processes; Chaperones Gene Ontology: Biological process GO:0006457 protein folding Molecular function GO:0005524 ATP binding GO:0051082 unfolded protein binding Pathway: pathway table Primary Evidence: Lopatin DE, Combs A, Sweier DG, Fenno JC, Dhamija S. Characterization of heat-inducible expression and cloning of HtpG (Hsp90 homologue) of Porphyromonas gingivalis. Infect Immun. 2000 Apr;68(4):1980-7. PMID: 10722592 Lopatin DE, Jaramillo E, Edwards CA, Van Poperin N, Combs A, Shelburne CE. Cellular localization of a Hsp90 homologue in Porphyromonas gingivalis. FEMS Microbiol Lett. 1999 Dec 1;181(1):9-16. PMID: 10564783 Comment: Lopatin et al. (2000) report that the P.g. Hsp90 cross-reacts with human Hsp90. A 68 kDa polypeptide is located in cytosolic fractions. TIGR ID: PG0045 Proteomic Data: Proteomic Data Search

TIGR Annotation		heat shock protein HtpG, GroupM (protein fate)
ORF #		PG-PP/PG-PPC1				PG-PP/PG-PPC2
		Spectral Count		Peptide Intensity		Spectral Count		Peptide Intensity
		Pro	qVal	Pro	qVal	Pro	qVal	Pro	qVal
TIGR	PG0045	0.92	0.0021	0.72	0.0095	0.62	0.0053	0.72	0.0095
LANL	PG0038	1.89		1.64		1.54		1.66
Consensus		SP1		IP1		SP2		IP2

Human Oral Microbiome Database: View in HOMD Genome Viewer Blast Summary: PSI-Blast Search Numerous significant hits in gapped BLAST to heat shock proteins; e.g. residues 3-579 are 36% similar to the heat shock protein of Synechocystis sp (D90917); residues 22-584 are 31% similar to the heat shock protein HtpG of Escherichia coli (U82664); residues 22-465 are 33% similar to the high temperature protein G of Actinobacillus actinomycetemcomitans (U26968). This sequence is similar to BT0897. Top Blast Hits: Updated monthly Click here to view the entire PsiBlast results. gi|34539918|ref|NP_904397.1| heat shock protein 90 [Porphyr... 1317 0.0 gi|150007331|ref|YP_001302074.1| chaperone protein HtpG [Pa... 900 0.0 gi|154492182|ref|ZP_02031808.1| hypothetical protein PARMER... 880 0.0 gi|156861092|gb|EDO54523.1| hypothetical protein BACUNI_019... 836 0.0 gi|150005807|ref|YP_001300551.1| chaperone protein [Bactero... 835 0.0 gi|15559056|gb|AAL02103.1|AF404759_2 heat shock protein Htp... 832 0.0 gi|60681971|ref|YP_212115.1| heat shock protein 90 [Bactero... 832 0.0 gi|29346307|ref|NP_809810.1| heat shock protein 90 [Bactero... 831 0.0 gi|53713700|ref|YP_099692.1| heat shock protein 90 [Bactero... 830 0.0 gi|153806301|ref|ZP_01958969.1| hypothetical protein BACCAC... 827 0.0 InterPro Summary: InterProScan InterPro IPR001404 Family Heat shock protein Hsp90 PR00775 HEATSHOCK90 PTHR11528 Hsp90 PF00183 HSP90 PS00298 HSP90 InterPro IPR003594 Domain ATP-binding region, ATPase-like G3DSA:3.30.565.10 ATP_bd_ATPase PF02518 HATPase_c SM00387 HATPase_c SSF55874 ATP_bd_ATPase noIPR unintegrated unintegrated PTHR11528:SF25 PTHR11528:SF25 SSF54211 SSF54211 COGS Summary: COGS Search BeTs to 9 clades of COG0326 COG name: Molecular chaperone, HSP90 family Functional Class: O The phylogenetic pattern of COG0326 is ----Y--cebrhuj--ol--x Number of proteins in this genome belonging to this COG is 1 Blocks Summary: Blocks Search ***** IPB001404 (Heat shock hsp90 proteins family) with a combined E-value of 1.3e-74. IPB001404A 3-47 IPB001404B 64-108 IPB001404C 108-151 IPB001404D 164-197 IPB001404E 208-262 IPB001404F 285-316 IPB001404G 320-356 IPB001404I 436-478 IPB001404J 541-594 ProDom Summary: Protein Domain Search Residues 427-579 are 25% similar to a (HEAT SHOCK PROTEIN CHAPERONE ATP-BINDING HSP) protein domain (PD000904 which is seen in P74702_SYNY3. Residues 11-201 are 49% similar to a (HEAT SHOCK PROTEIN CHAPERONE) protein domain (PD000898 which is seen in P74702_SYNY3. Paralogs: Local Blast Search No paralogs found in P. gingivalis. Pfam Summary: Pfam Search Residues 25 to 176 (E-value = 7.6e-13) place PG0038 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518) Residues 179 to 642 (E-value = 1e-08) place PG0038 in the HSP90 family which is described as Hsp90 protein (PF00183) Structural Feature(s): Feature Type Start Stop coil-coil 80 112 coil-coil 589 637 transmembrane 653 669 Top PDB Hits: -49% similar to PDB:2IOP Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP (E_value = 9.4E_68); -49% similar to PDB:2IOQ Crystal Structure of full-length HTPG, the Escherichia coli HSP90 (E_value = 9.4E_68); -51% similar to PDB:1Y4S Conformation rearrangement of heat shock protein 90 upon ADP binding (E_value = 8.0E_67); -51% similar to PDB:1Y4U Conformation rearrangement of heat shock protein 90 upon ADP binding (E_value = 8.0E_67); -47% similar to PDB:2CG9 CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX (E_value = 3.2E_47); Gene Protein Sequence: MSKKGTIGVTSDNIFPVIKKFLYSDHEIFLREIVSNAVDATQKLKTLTSV GEFKGETGDLRVTVSVDEVARTITVSDRGVGMTEEEVEKYINQIAFSSAE EFLEKYKDDKAAIIGHFGLGFYSAFMVSERVDVITRSFREDATAVKWSCD GSPEYTLEPADKADRGTDIVMHIDEENSEFLKKEKIEGLLGKYCKFLTVP IIFGKKQEWKDGKMQDTDEDNQINDTHPAWTKKPADLKDEDYKEFYRSLY PMSEEPLFWIHLNVDYPFNLTGILYFPKIKNNLDLQRNKIQLYCNQVYVT DEVQGIVPDFLTLLHGVIDSPDIPLNVSRSYLQSDANVKKISSHITKKVA DRLEEIFKNDRPTFEEKWDSLKLFVEYGMLTDEKFYERAAKFFLFTDMDG HKYTFDEYRTLVEGVQTDKDGQVVYLYATDKHGQYSHVKRASDKGYSVML LDGQLDPHIVSLLEQKLEKTHFVRVDSDTINNLIRKEERAEVKLSDTERA TLVKLFEARLPRDEKKHFNVAFESLGAEGEAILITQAEFMRRMRDMAQLQ PGMSFYGELPDSYNLVLNTDHPLIDRVLSGEKESVEPSLTELRAKIAELK AEEAKLLDEEKGKKPEEIPVATKEAKENNAVEQAKTEGSINDQLTKYAQD NELIGQLIDLALLGSGLLTGEALAEFIRRSQRLL Gene Nucleotide Sequence: Sequence Viewer ATGAGTAAGAAAGGAACAATCGGGGTAACGAGCGACAATATATTCCCCGT CATCAAAAAATTCCTGTACAGCGACCATGAGATATTCCTGCGTGAGATCG TCTCCAATGCCGTGGATGCTACGCAGAAGCTGAAAACGCTTACATCCGTC GGCGAATTCAAAGGCGAGACGGGTGACCTCCGCGTAACGGTCAGCGTGGA TGAAGTGGCACGCACGATCACGGTCAGCGACCGCGGCGTAGGGATGACCG AAGAGGAGGTGGAGAAGTACATCAATCAGATTGCTTTCTCCAGTGCGGAA GAGTTTCTTGAAAAGTACAAAGACGACAAGGCCGCCATTATCGGCCACTT CGGACTCGGATTTTACTCGGCTTTCATGGTGTCCGAGCGAGTGGACGTGA TCACGCGCTCTTTCCGAGAAGATGCTACGGCGGTGAAATGGAGCTGCGAC GGATCGCCCGAATACACGCTCGAACCTGCGGACAAGGCTGACCGTGGCAC CGACATCGTGATGCACATCGATGAGGAGAATAGCGAGTTCCTCAAAAAAG AAAAGATAGAGGGGCTCCTCGGCAAATACTGTAAGTTCCTTACCGTGCCG ATCATTTTCGGCAAGAAGCAGGAATGGAAAGACGGCAAGATGCAAGATAC GGACGAGGACAATCAGATCAACGACACACATCCTGCCTGGACCAAAAAGC CTGCCGACCTCAAGGACGAAGACTATAAGGAATTTTACCGTTCGCTCTAT CCCATGTCCGAAGAGCCTCTCTTCTGGATCCACCTCAATGTGGACTATCC GTTCAATCTGACAGGTATCCTCTATTTCCCGAAGATCAAAAACAACTTGG ATCTGCAGCGCAACAAGATTCAGCTCTACTGCAATCAGGTTTACGTCACC GATGAAGTACAGGGTATCGTGCCGGACTTCCTCACCCTCCTGCACGGGGT CATCGATTCGCCGGATATTCCCCTCAACGTATCGCGCTCCTATCTGCAGA GCGATGCCAATGTGAAGAAGATCTCGTCTCATATCACCAAGAAGGTGGCA GACCGTCTGGAAGAAATTTTCAAAAACGACCGCCCCACATTCGAGGAGAA ATGGGATAGTCTGAAGCTCTTCGTCGAATACGGTATGCTGACGGATGAGA AGTTCTATGAGCGTGCAGCCAAATTCTTCCTTTTCACCGATATGGACGGA CACAAGTACACGTTCGACGAATACCGAACGCTCGTCGAAGGTGTACAGAC GGATAAGGACGGACAGGTAGTGTATCTCTATGCTACGGACAAGCATGGAC AGTACAGCCACGTGAAACGTGCATCCGACAAAGGCTACAGCGTGATGCTG TTGGATGGTCAGTTGGATCCGCATATCGTGAGCCTGCTGGAGCAAAAGTT GGAGAAGACACACTTTGTCCGTGTCGATAGCGATACGATCAACAATCTGA TCCGCAAGGAGGAAAGAGCCGAAGTGAAACTGTCCGATACGGAGCGCGCC ACTCTCGTGAAGCTGTTCGAAGCACGCCTGCCACGGGACGAGAAGAAGCA CTTCAATGTAGCTTTCGAATCGCTCGGAGCCGAAGGTGAAGCCATCCTTA TCACACAAGCCGAATTCATGCGCCGTATGCGCGATATGGCACAGCTGCAG CCGGGAATGAGCTTCTACGGCGAACTCCCCGATTCGTACAATCTGGTACT TAATACCGATCATCCGCTCATCGACAGGGTACTCTCCGGTGAGAAAGAAT CGGTAGAGCCTTCGCTCACAGAGCTTAGAGCGAAAATCGCCGAGCTGAAA GCGGAAGAGGCCAAGCTGCTCGATGAGGAAAAAGGGAAGAAACCGGAGGA AATCCCTGTTGCCACGAAGGAAGCCAAGGAGAACAACGCCGTCGAACAGG CCAAAACCGAAGGCAGTATCAACGATCAACTGACCAAATATGCTCAGGAC AACGAGCTGATAGGTCAGCTCATCGACTTGGCTCTGCTCGGAAGCGGATT GCTGACGGGAGAGGCTTTGGCCGAATTCATTCGTCGCAGCCAGCGTCTTC TC Los Alamos National Laboratory • Est 1943 Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy

`Feature Type`	`Start`	`Stop`
`coil-coil`	`80`	`112`
`coil-coil`	`589`	`637`
`transmembrane`	`653`	`669`