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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0038 IGR0037 IGR0039 IGR0040 IGR0036 cdsA, - PG0040 ychF, - PG0042 ftsH, - PG0041 PG0037 ISPg4,tnp, - PG0043 htpG, - PG0038 PG0036 cdsA, - PG0040 ychF, - PG0042 ftsH, - PG0041 PG0037 ISPg4,tnp, - PG0043 htpG, - PG0038 PG0036 Type: IS element, Name: ISPg4 - 7 cdsA, - PG0040 ychF, - PG0042 ftsH, - PG0041 PG0037 ISPg4,tnp, - PG0043 htpG, - PG0038 PG0036


LANL Gene ID: PG0040

GenBank Locus Tag: PG0046

DNA Molecule Name:
1  

Genomic Island ID:
20

GenBank ID:
34539919

 Gene Name:
cdsA  

 Definition:
phosphatidate cytidylytransferase (CDP diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase)

 Cellular Location:
Inner membrane, Cytoplasm [Evidence]

 Gene Start:
57290

Gene Stop:
56439

Gene Length:
852

Molecular Weight*:
31292

pI*:
9.90

Net Charge*:
4.92

EC:
2.7.7.41  

 Functional Class:
Fatty acid and phospholipid metabolism  

 Gene Ontology:
Biological process
  GO:0008654    phospholipid biosynthetic process

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0004605    phosphatidate cytidylyltransferase activity


 Pathway: pathway table
Glycerolipid metabolism

 Comment:
TIGR ID: PG0046

 Proteomic Data: Proteomic Data Search
TIGR Annotationphosphatidate cytidylyltransferase, GroupI (fatty acid and phospholipid metabolism)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG00460.160.220.770.033.450.00160.770.03
LANLPG00401.121.7010.9278.36
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST to phosphatidate cytidylyltransferase protein; e.g. residues 154-282 are 44% similar to (U70214) phosphatidate cytidylyltransferase of Escherichia coli, residues 7-280 are 29% similar to (U32773) CDP-diglyceride synthetase (cdsA) of Haemophilus influenzae Rd, residues 154-282 are 43% similar to (Z99112) phosphatidate cytidylyltransferase (CDP-diglyceride synthase) of Bacillus subtilis.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539919|ref|NP_904398.1|  phosphatidate cytidylyltransfe...   499   e-140
 gi|154494842|ref|ZP_02033847.1|  hypothetical protein PARMER...   181   5e-44
 gi|150008469|ref|YP_001303212.1|  phosphatidate cytidylyltra...   177   7e-43
 gi|53712066|ref|YP_098058.1|  phosphatidate cytidylyltransfe...   164   8e-39
 gi|60680260|ref|YP_210404.1|  putative phosphatidate cytidyl...   162   2e-38
 gi|156107223|gb|EDO08968.1|  hypothetical protein BACOVA_048...   162   2e-38
 gi|156859431|gb|EDO52862.1|  hypothetical protein BACUNI_036...   159   1e-37
 gi|150004471|ref|YP_001299215.1|  phosphatidate cytidylyltra...   157   5e-37
 gi|153807420|ref|ZP_01960088.1|  hypothetical protein BACCAC...   146   2e-33
 gi|146300353|ref|YP_001194944.1|  phosphatidate cytidylyltra...   142   2e-32


InterPro Summary:  InterProScan

InterPro
IPR000374
Family
Phosphatidate cytidylyltransferase
PF01148 [5-282]T 4.699982625131889E-54 PF01148 CTP_transf_1 CTP_transf_1
PS01315 [240-266]T 8.0E-5 PS01315 CDS CDS
noIPR
unintegrated
unintegrated
PD002096 [224-261]T 0.0 PD002096 PD002096 PD002096
PTHR13773 [155-208]T 2.6999988713205702E-8 PTHR13773 PTHR13773 PTHR13773


COGS Summary:  COGS Search
BeTs to 16 clades of COG0575
COG name: CDP-diglyceride synthetase
Functional Class: I
The phylogenetic pattern of COG0575 is amtkyqvcEbrhujgpolinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB000374 (Phosphatidate cytidylyltransferase) with a combined E-value of 2e-37.
    IPB000374A    151-192
    IPB000374B    229-272


 ProDom Summary:  Protein Domain Search
Residues 154-281 are 43% similar to a (PHOSPHATIDATE CYTIDYLYLTRANSFERASE SYNTHASE) protein domain (PD002096 which is seen in CDSA_ECOLI.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 5 to 282 (E-value = 4.1e-57) place PG0040 in the CTP_transf_1 family which is described as Cytidylyltransferase family (PF01148)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
12  
36
transmembrane  
67  
91
transmembrane  
118  
135
transmembrane  
132  
148
transmembrane  
150  
166
transmembrane  
153  
176
transmembrane  
183  
199
transmembrane  
193  
210
transmembrane  
206  
222
transmembrane  
218  
235
transmembrane  
242  
258
transmembrane  
267  
284
transmembrane  
279  
295
transmembrane  
317  
333
transmembrane  
345  
361
transmembrane  
392  
408

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
MKAVLIRSLSGLVYMALIILPVVLREPALFLAVFAVFIVLGLREFASLVN
LNRTRPLRAFMDGLFGAFLFAAIFLYGSDRMDVTIFIPYIFYVLYTMVRS
LYSDRHKAGSDNSRTFMGHLYIAATLGLGSLLLVPESIGRELAVGEVADF
TPHYFLFVFVLIWLNDTGAFIAGSLFGKHTLFKVISPKKTWEGFIGGLLF
TVAGALLAGHYSGSAKHPMELVFFALLVTAMATWGDLYESNLKRNAGVKD
SGHIIPGHGGILDRLDSALFVFPAVYLFILIFGL

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAGCAGTTTTGATTCGCAGCCTCAGTGGTCTGGTCTATATGGCCCT
GATCATCCTTCCCGTCGTACTAAGGGAACCGGCTTTGTTCTTAGCGGTTT
TTGCCGTTTTCATCGTGTTGGGACTGCGGGAATTCGCCTCGCTGGTCAAT
CTGAATCGCACACGTCCCCTTCGGGCATTCATGGACGGACTTTTCGGTGC
CTTCCTCTTTGCGGCCATCTTCCTATACGGCAGTGACCGAATGGATGTCA
CGATATTTATCCCGTATATCTTCTATGTCCTCTACACTATGGTGCGCAGT
CTATATTCGGATCGCCATAAGGCCGGATCGGACAATAGCCGCACTTTCAT
GGGGCATCTGTATATAGCGGCAACGCTTGGTTTGGGTAGTCTTCTGCTCG
TGCCCGAAAGTATCGGCAGGGAGTTGGCAGTAGGAGAAGTGGCAGACTTC
ACGCCTCACTACTTCCTCTTCGTTTTTGTGCTGATATGGCTGAATGATAC
AGGAGCTTTTATTGCAGGTTCCCTCTTTGGCAAGCATACACTCTTCAAGG
TCATATCACCCAAGAAAACATGGGAGGGCTTTATCGGAGGGCTGCTGTTC
ACTGTGGCAGGTGCATTGCTGGCAGGCCACTATTCCGGTTCGGCCAAGCA
TCCGATGGAGCTGGTCTTCTTTGCTCTACTGGTAACGGCCATGGCCACTT
GGGGCGATCTGTATGAGTCCAATCTCAAACGCAATGCAGGAGTGAAGGAT
TCCGGCCATATCATTCCCGGACATGGAGGTATACTGGACCGGCTGGACAG
TGCTCTCTTCGTATTCCCGGCCGTCTATCTTTTCATTCTGATCTTCGGAT
TG

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