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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0044 IGR0039 IGR0042 IGR0041 IGR0040 IGR0043 ychF, - PG0042 ftsH, - PG0041 ISPg1, - PG0044 PG0047 ISPg4,tnp, - PG0043 PG0045 PG0048 recJ, - PG0046 ychF, - PG0042 ftsH, - PG0041 ISPg1, - PG0044 PG0047 ISPg4,tnp, - PG0043 PG0045 PG0048 recJ, - PG0046 Type: IS element, Name: ISPg1 fragment - 3 Type: IS element, Name: ISPg4 - 7 ychF, - PG0042 ftsH, - PG0041 ISPg1, - PG0044 PG0047 ISPg4,tnp, - PG0043 PG0045 PG0048 recJ, - PG0046


LANL Gene ID: PG0045

GenBank Locus Tag: PG0052

DNA Molecule Name:
1  

GenBank ID:
34539924

Gene Name:


Definition:
histidine kinase sensor protein

Cellular Location:
Inner membrane, Cytoplasm [Evidence]

Gene Start:
63559

Gene Stop:
64743

Gene Length:
1185

Molecular Weight*:
44692

pI*:
10.20

Net Charge*:
10.46

EC:
 

Functional Class:
Uncategorized  

Gene Ontology:
Biological process
  GO:0007165    signal transduction
  GO:0016310    phosphorylation
  GO:0018106    peptidyl-histidine phosphorylation

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0000155    two-component sensor activity
  GO:0004673    protein histidine kinase activity
  GO:0005524    ATP binding
  GO:0016772    transferase activity, transferring phosphorus-containing groups


Pathway: pathway table

Comment:
TIGR ID: PG0052

Human Oral Microbiome Database:
View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST to sensor proteins; e.g. residues 145-389 are 27% similar to the two-component sensor histidine kinase of Bacillus subtilis (Z99111); residues 192-389 are 30% similar to the sensor protein AtoS for response regulator AtoC of Escherichia coli (AE000311); residues 174-389 are 31% similar to the Salmonella typhimurium sensor protein of Salmonella typhimurium LT2 (AF170176).

Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539924|ref|NP_904403.1|  sensor histidine kinase [Porph...   770   0.0  
 gi|150009042|ref|YP_001303785.1|  two-component sensor histi...   382   e-104
 gi|154494313|ref|ZP_02033633.1|  hypothetical protein PARMER...   361   5e-98
 gi|126663049|ref|ZP_01734047.1|  sensor histidine kinase [Fl...   297   8e-79
 gi|120437370|ref|YP_863056.1|  two-component system sensor h...   294   7e-78
 gi|126648708|ref|ZP_01721192.1|  sensor histidine kinase [Al...   288   3e-76
 gi|124005215|ref|ZP_01690057.1|  sensor histidine kinase [Mi...   285   3e-75
 gi|150026379|ref|YP_001297205.1|  Probable two-component sys...   283   1e-74
 gi|86143819|ref|ZP_01062195.1|  sensor histidine kinase [Fla...   281   4e-74
 gi|83855758|ref|ZP_00949287.1|  sensor histidine kinase [Cro...   280   9e-74


InterPro Summary:  InterProScan

InterPro
IPR003594
Domain
ATP-binding region, ATPase-like
G3DSA:3.30.565.10 [241-389]T 3.8999986179521803E-28 G3DSA:3.30.565.10 ATP_bd_ATPase ATP_bd_ATPase
PF02518 [284-391]T 3.49999466863949E-22 PF02518 HATPase_c HATPase_c
SM00387 [284-392]T 2.90000000000029E-20 SM00387 HATPase_c HATPase_c
SSF55874 [245-389]T 9.400000000000001E-35 SSF55874 ATP_bd_ATPase ATP_bd_ATPase
InterPro
IPR003661
Domain
Histidine kinase A, N-terminal
PF00512 [183-242]T 5.39999977351167 PF00512 HisKA HisKA
SM00388 [183-242]T 0.3 SM00388 HisKA HisKA
InterPro
IPR004358
Domain
Histidine kinase related protein, C-terminal
PR00344 [321-335]T 1.5E-15 PR00344 BCTRLSENSOR[339-349]T 1.5E-15 PR00344 BCTRLSENSOR[350-368]T 1.5E-15 PR00344 BCTRLSENSOR[376-389]T 1.5E-15 PR00344 BCTRLSENSOR BCTRLSENSOR
InterPro
IPR005467
Domain
Histidine kinase
PS50109 [190-392]T 0.0 PS50109 HIS_KIN HIS_KIN
InterPro
IPR009082
Domain
Histidine kinase, homodimeric
SSF47384 [173-241]T 5.900000000000001E-7 SSF47384 His_kin_homodim His_kin_homodim
noIPR
unintegrated
unintegrated
PTHR23283 [173-393]T 9.199984144203112E-36 PTHR23283 PTHR23283 PTHR23283
PTHR23283:SF24 [173-393]T 9.199984144203112E-36 PTHR23283:SF24 PTHR23283:SF24 PTHR23283:SF24


COGS Summary:  COGS Search
BeTs to 13 clades of COG0642
COG name: Sensory transduction histidine kinases
Functional Class: T
The phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inX
Number of proteins in this genome belonging to this COG is 6
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 292-389 are 42% similar to a (KINASE PROTEIN SENSORY TRANSDUCTION HISTIDINE SENSOR) protein domain (PD000064 which is seen in KINC_BACSU.


Paralogs:  Local Blast Search
Residues 155-391 are 26% similar to PG1571, residues 175-389 are 22% similar to PG0014 and residues 109-368 are 23% similar to PG1255.

Pfam Summary:  Pfam Search
Residues 284 to 391 (E-value = 1.9e-24) place PG0045 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable signal  
1  
27
transmembrane  
18  
35
transmembrane  
153  
170
transmembrane  
156  
172
transmembrane  
279  
296

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
MSWSGNQTFFERSRIMMRVTFIFAAMVIALLTLFASDRLIDKMAGEERQK
IELWAQATKIVASDDEAVLAKDLVLQIIQSNNSIPVILCDPKDSIISYNN
IDIPAGKPALPYLQKKLRYFKEGYPPIRIEIEARRPQFLYYSDSQTLRRL
LVLPYIALSVIFIFLGISIMALLAERRSEQNRVWNGLSKETAHQLGTPIS
SLMAWVELLKASEEDPSITNEMEKDIDRLRMIAERFQKVGSEPKTEVQDV
RPALGSTADYMRYRVSRQVDIELRMPNEVIGIALSAPLFSWVIENMIKNA
VDAMSGKGKITIELKEKGSYAVIDITDTGKGIPKGKMRDIFRPGYSTKTR
GWGLGLSLAKRIIEKYHKGKISVKQSEPGIGTTFRILLPKQTDLP

Gene Nucleotide Sequence:  Sequence Viewer
ATGAGCTGGAGCGGTAATCAAACATTCTTCGAGCGAAGCCGCATCATGAT
GCGCGTTACCTTTATTTTCGCCGCCATGGTCATTGCTCTCCTTACGTTGT
TTGCTTCGGACAGACTGATCGATAAGATGGCCGGCGAGGAAAGACAGAAA
ATCGAGCTATGGGCACAGGCTACCAAGATCGTGGCCTCCGACGATGAAGC
CGTTCTGGCCAAAGACCTTGTTTTGCAGATTATCCAATCCAACAATAGCA
TCCCCGTCATCCTGTGCGATCCCAAAGACTCTATTATTTCGTACAACAAC
ATCGACATTCCGGCCGGCAAACCTGCACTGCCCTACCTCCAAAAGAAGCT
TCGTTATTTCAAGGAAGGGTATCCTCCTATCCGAATAGAAATAGAGGCCC
GTCGGCCACAATTCCTCTATTATTCCGACAGCCAAACCCTACGGCGACTG
TTGGTATTGCCTTATATAGCTCTGAGCGTGATATTTATCTTCCTCGGTAT
TTCCATCATGGCCTTGCTGGCTGAGCGCAGATCCGAACAGAATCGTGTAT
GGAACGGACTCTCCAAAGAGACTGCCCATCAGCTTGGCACGCCCATATCC
AGCCTGATGGCATGGGTGGAACTCCTCAAGGCATCGGAAGAGGATCCATC
TATCACCAATGAGATGGAAAAGGATATAGACCGACTGCGTATGATAGCCG
AACGATTCCAAAAGGTAGGCTCGGAACCCAAGACGGAAGTGCAGGATGTC
CGTCCGGCTTTGGGCAGCACAGCGGACTACATGCGCTACCGCGTATCGCG
ACAAGTGGACATAGAATTGAGGATGCCGAATGAGGTCATCGGCATAGCAC
TTTCGGCACCGCTGTTCAGTTGGGTGATCGAAAATATGATCAAAAATGCC
GTCGATGCCATGAGCGGTAAAGGAAAGATCACGATCGAACTTAAGGAGAA
AGGCTCGTATGCAGTAATAGATATTACCGACACGGGCAAAGGGATCCCCA
AGGGGAAAATGCGCGATATATTCCGTCCGGGCTATTCCACGAAGACCAGA
GGTTGGGGTTTGGGCTTGTCTCTGGCAAAGCGAATCATAGAGAAATATCA
CAAAGGGAAAATAAGCGTAAAGCAATCGGAGCCGGGTATTGGCACTACTT
TCCGTATTCTGCTGCCGAAACAGACCGATCTGCCA

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