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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0046 IGR0049 IGR0047 IGR0045 IGR0044 IGR0048 PG0051 nadD,yqeJ, - PG0050 PG0047 pncB, - PG0049 yngK, - PG0052 PG0048 recJ, - PG0046 PG0053 PG0051 nadD,yqeJ, - PG0050 PG0047 pncB, - PG0049 yngK, - PG0052 PG0048 recJ, - PG0046 PG0053 PG0051 nadD,yqeJ, - PG0050 PG0047 pncB, - PG0049 yngK, - PG0052 PG0048 recJ, - PG0046 PG0053


LANL Gene ID: PG0049

GenBank Locus Tag: PG0057

DNA Molecule Name:
1  

GenBank ID:
34539929

Gene Name:
pncB  

Definition:
nicotinate phosphoribosyltransferase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
69875

Gene Stop:
71056

Gene Length:
1182

Molecular Weight*:
45457

pI*:
6.50

Net Charge*:
-3.22

EC:
2.4.2.11  

Functional Class:
Biosynthesis of cofactors, prosthetic groups and carriers; Pyridine nucleotides  

Gene Ontology:
Biological process
  GO:0019357    nicotinate nucleotide biosynthetic process
  GO:0019363    pyridine nucleotide biosynthetic process

Molecular function
  GO:0004516    nicotinate phosphoribosyltransferase activity


Pathway: pathway table
Nicotinate and nicotinamide metabolism

Comment:
TIGR ID: PG0057

Proteomic Data: Proteomic Data Search
TIGR Annotationnicotinate phosphoribosyltransferase, GroupB (biosynthesis of cofactors, prosthetic groups, and carriers)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0057-0.470.055-0.220.150.560.037-0.220.15
LANLPG00490.720.861.470.88
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Several hits in gapped BLAST to nicotinate phosphoribosyltransferase sequences, e.g. residues 3-374 are 38% similar to the enzyme from P.aeruginosa (strain PAO1)(AE004905).

This sequence is similar to BT1913.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539929|ref|NP_904408.1|  nicotinate phosphoribosyltrans...   819   0.0  
 gi|29347323|ref|NP_810826.1|  nicotinate phosphoribosyltrans...   399   e-109
 gi|156111219|gb|EDO12964.1|  hypothetical protein BACOVA_014...   392   e-107
 gi|153809395|ref|ZP_01962063.1|  hypothetical protein BACCAC...   392   e-107
 gi|53714809|ref|YP_100801.1|  nicotinate phosphoribosyltrans...   385   e-105
 gi|60682801|ref|YP_212945.1|  nicotinate phosphoribosyltrans...   385   e-105
 gi|156860140|gb|EDO53571.1|  hypothetical protein BACUNI_028...   382   e-104
 gi|67480593|ref|XP_655646.1|  nicotinate phosphoribosyltrans...   368   e-100
 gi|92113069|ref|YP_572997.1|  Nicotinate phosphoribosyltrans...   354   6e-96
 gi|146300227|ref|YP_001194818.1|  nicotinate phosphoribosylt...   343   1e-92


InterPro Summary:  InterProScan

InterPro
IPR006406
Family
Nicotinate phosphoribosyltransferase
PIRSF000484 [2-394]T 0.0 PIRSF000484 NAPRT NAPRT
TIGR01514 [3-393]T 0.0 TIGR01514 NAPRTase NAPRTase
InterPro
IPR007229
Family
Nicotinate phosphoribosyltransferase and related
PTHR11098:SF1 [3-380]T 1.50000965748784E-69 PTHR11098:SF1 NAPRTase NAPRTase
PF04095 [162-393]T 2.60000517657743E-46 PF04095 NAPRTase NAPRTase
noIPR
unintegrated
unintegrated
G3DSA:3.20.140.10 [2-393]T 9.099924325423259E-125 G3DSA:3.20.140.10 G3DSA:3.20.140.10 G3DSA:3.20.140.10
PTHR11098 [3-380]T 1.50000965748784E-69 PTHR11098 PTHR11098 PTHR11098
SSF54675 [2-137]T 4.1E-32 SSF54675 SSF54675[138-390]T 7.300000000000002E-67 SSF54675 SSF54675 SSF54675


COGS Summary:  COGS Search
BeTs to 6 clades of COG1488
COG name: Nicotinic acid phosphoribosyltransferase
Functional Class: H
The phylogenetic pattern of COG1488 is a--kyqvcebR---gpol---
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 3-374 are 39% similar to a (NICOTINATE PHOSPHORIBOSYLTRANSFERASE) protein domain (PD025025 which is seen in PNCB_ECOLI.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 5 to 393 (E-value = 4.5e-81) place PG0049 in the NAPRTase family which is described as Nicotinate phosphoribosyltransferase (NAPRTase) family (PF04095)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-55% similar to PDB:1YIR Crystal Structure of a Nicotinate Phosphoribosyltransferase (E_value = 1.1E_59);
-52% similar to PDB:1VLP Crystal structure of nicotinate phosphoribosyltransferase (yor209c) from Saccharomyces cerevisiae at 1.75 A resolution (E_value = 2.5E_51);
-46% similar to PDB:1YBE Crystal Structure of a Nicotinate phosphoribosyltransferase (E_value = 2.5E_35);

Gene Protein Sequence:
MGIIRSILDTDLYKFTTGYAYAKLFPRAYGEFRFIDRNRQGFTEEFAELV
RGEIRAMAALSLTRDEKEFLQRELPYLPPIYIDFLDGFRFDPEEVTVSID
AQGHLDIRAQGLLYRVTLWETPILAVISELYYRFIGAEPDWKQVEEVTRS
KGELMREHRATFSIFGMRRRFSLEVEDRVTDILKQYAGESLFGTSNVHLA
HKHGLRVSGTHPHEWIQFHGAIYGYKMANYVAMEDWINVYDGDLGTVLTD
TYTTDVFMRNFSKKHAMLFTSLRHDSGDPEIFIEKAVRRYEELRVDPKIK
YIIFSDSLTPQRAIEIQKLCAGRIKASFGIGTNLTNDVGGGVEPLNIVMK
LWKCKMTAKDDWHYCVKLSDVDGKHTGEPEEILLAMNTLGIKPK

Gene Nucleotide Sequence:  Sequence Viewer
ATGGGTATTATCCGGAGCATATTAGACACCGATCTATATAAATTCACCAC
CGGCTATGCCTATGCCAAGCTATTCCCCAGAGCTTATGGCGAATTTCGCT
TCATAGACCGTAATCGGCAGGGCTTTACGGAAGAATTTGCGGAGCTGGTG
CGAGGTGAAATACGAGCGATGGCTGCTCTGTCTTTGACTCGTGATGAAAA
AGAGTTTCTCCAACGAGAGCTTCCTTATCTTCCACCGATATATATCGATT
TTCTCGATGGCTTCCGTTTCGATCCGGAAGAAGTTACAGTATCGATAGAC
GCACAAGGCCACTTGGATATACGAGCGCAAGGCCTTCTCTACCGAGTGAC
ACTTTGGGAGACGCCTATCCTTGCCGTCATCAGCGAGCTGTACTATCGTT
TTATTGGAGCCGAGCCGGATTGGAAACAAGTAGAAGAGGTAACTCGATCT
AAAGGGGAGCTGATGCGAGAGCATCGAGCTACGTTCTCGATATTCGGTAT
GCGGCGGCGTTTCTCCCTTGAAGTGGAAGACCGTGTGACGGATATTCTCA
AGCAGTATGCAGGTGAGAGTCTCTTTGGTACGAGCAACGTACACCTTGCC
CATAAGCATGGGCTACGTGTTTCCGGCACACATCCACACGAATGGATACA
ATTCCATGGAGCTATTTACGGCTATAAGATGGCCAATTATGTAGCCATGG
AGGATTGGATCAATGTCTATGACGGTGATCTTGGCACTGTGCTGACCGAT
ACGTACACGACTGATGTCTTCATGCGCAATTTCAGTAAGAAGCATGCCAT
GCTCTTTACCAGTCTGAGACATGACAGTGGTGATCCCGAGATATTCATAG
AAAAAGCAGTGCGACGATACGAAGAGCTGCGAGTGGATCCCAAAATCAAG
TACATTATATTCTCTGACAGCCTCACTCCTCAGCGAGCTATAGAGATTCA
AAAGTTGTGCGCCGGCAGGATTAAGGCCAGCTTTGGAATCGGTACCAATC
TGACCAATGATGTGGGGGGGGGCGTAGAGCCGTTGAATATCGTAATGAAG
CTCTGGAAGTGCAAGATGACGGCGAAAGACGACTGGCACTACTGTGTAAA
GCTGAGCGACGTCGATGGTAAGCATACGGGAGAGCCGGAAGAAATCCTTT
TGGCGATGAATACACTGGGTATCAAACCGAAA

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