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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0046 IGR0049 IGR0047 IGR0045 IGR0050 IGR0044 IGR0048 PG0054 PG0051 nadD,yqeJ, - PG0050 PG0047 pncB, - PG0049 yngK, - PG0052 PG0048 recJ, - PG0046 PG0053 PG0054 PG0051 nadD,yqeJ, - PG0050 PG0047 pncB, - PG0049 yngK, - PG0052 PG0048 recJ, - PG0046 PG0053 PG0054 PG0051 nadD,yqeJ, - PG0050 PG0047 pncB, - PG0049 yngK, - PG0052 PG0048 recJ, - PG0046 PG0053


LANL Gene ID: PG0050

GenBank Locus Tag: PG0058

DNA Molecule Name:
1  

GenBank ID:
34539930

Gene Name:
nadD  yqeJ  

Definition:
nicotinate-nucleotide adenylyltransferase (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase)

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
71059

Gene Stop:
71649

Gene Length:
591

Molecular Weight*:
23036

pI*:
7.60

Net Charge*:
1.78

EC:
2.7.7.18  

Functional Class:
Uncategorized  

Gene Ontology:
Biological process
  GO:0009058    biosynthetic process
  GO:0009435    NAD biosynthetic process

Molecular function
  GO:0003824    catalytic activity
  GO:0016779    nucleotidyltransferase activity


Pathway: pathway table
Nicotinate and nicotinamide metabolism

Comment:
TIGR ID: PG0058

Proteomic Data: Proteomic Data Search
TIGR Annotationcytidyltransferase family protein, GroupT (unknown function)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG00580.750.193.790.11-1.720.0363.790.11
LANLPG00501.6813.790.300.15
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Several hits in gapped BLAST to predicted nicotinate-nucleotide adenyltransferases, e.g. residues 4-177 are 29% similar to the enzyme from B.subtilis (Z99117). Residues 1-177 are 27% similar to NADD_BORBU.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539930|ref|NP_904409.1|  nicotinic acid mononucleotide ...   397   e-109
 gi|53714993|ref|YP_100985.1|  nicotinic acid mononucleotide ...   171   2e-41
 gi|156861160|gb|EDO54591.1|  hypothetical protein BACUNI_015...   168   2e-40
 gi|29347421|ref|NP_810924.1|  nicotinic acid mononucleotide ...   166   8e-40
 gi|153809503|ref|ZP_01962171.1|  hypothetical protein BACCAC...   162   1e-38
 gi|154493633|ref|ZP_02032953.1|  hypothetical protein PARMER...   159   1e-37
 gi|150006824|ref|YP_001301567.1|  putative nicotinate-nucleo...   159   1e-37
 gi|150004202|ref|YP_001298946.1|  putative nicotinate-nucleo...   158   1e-37
 gi|156111190|gb|EDO12935.1|  hypothetical protein BACOVA_014...   156   8e-37
 gi|126647017|ref|ZP_01719527.1|  nicotinic acid mononucleoti...   147   4e-34


InterPro Summary:  InterProScan

InterPro
IPR004820
Domain
Cytidylyltransferase
PF01467 [5-165]T 3.1999989904635493E-25 PF01467 CTP_transf_2 CTP_transf_2
InterPro
IPR004821
Domain
Cytidyltransferase-related
TIGR00125 [3-68]T 8.63022592649419E-7 TIGR00125 cyt_tran_rel cyt_tran_rel
InterPro
IPR005248
Family
Probable nicotinate-nucleotide adenylyltransferase
PTHR12039 [1-177]T 3.3999997243768694E-29 PTHR12039 NAMN_adtrnsfrase NAMN_adtrnsfrase
TIGR00482 [5-190]T 3.8416123150052596E-86 TIGR00482 NAMN_adtrnsfrase NAMN_adtrnsfrase
InterPro
IPR014729
Domain
Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620 [2-177]T 2.39999798157241E-44 G3DSA:3.40.50.620 Rossmann-like_a/b/a_fold Rossmann-like_a/b/a_fold
noIPR
unintegrated
unintegrated
SSF52374 [1-177]T 1.2999999999999998E-45 SSF52374 SSF52374 SSF52374


COGS Summary:  COGS Search
BeTs to 11 clades of COG1057
COG name: Predicted nucleotidyltransferases
Functional Class: R
The phylogenetic pattern of COG1057 is ----Yqvcebr-ujgpol---
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** PR01020 (Lipopolysaccharide core biosynthesis protein signature) with a combined E-value of 5.3e-06.
    PR01020A    2-20
    PR01020C    54-78


 ProDom Summary:  Protein Domain Search
Residues 5-134 are 29% similar to a (PROTEIN CONSERVED INTERGENIC REGION) protein domain (PD009578 which is seen in O66452_AQUAE.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 5 to 165 (E-value = 1.3e-27) place PG0050 in the CTP_transf_2 family which is described as Cytidylyltransferase (PF01467)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-49% similar to PDB:1KAM Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase (E_value = 3.0E_18);
-49% similar to PDB:1KAQ Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase (E_value = 3.0E_18);
-48% similar to PDB:2H29 Crystal structure of Nicotinic acid mononucleotide Adenylyltransferase from Staphylococcus aureus: product bound form 1 (E_value = 3.5E_11);
-48% similar to PDB:2H2A Crystal structure of Nicotinic acid mononucleotide adenylyltransferase from Staphylococcus aureus: product bound form 2 (E_value = 3.5E_11);

Gene Protein Sequence:
MLTGLFFGSFNPMHIGHLALANYLTEYTPIGQLWFVPSPLNPLKNTQELL
PYDLRCELIEQAIRKDIRFQVLRIEELLPSPHYTIRTLRALSMLYPHHRF
ALLIGADNWQSFDRWKDHHRLMAKYELIIYPRFGYEVDDTTLPTGCRYIH
DAPRIEISSTQIRTSILEGKDLRYWLPLPESQDVIASALQSCLSPKR

Gene Nucleotide Sequence:  Sequence Viewer
ATGCTGACGGGACTATTCTTCGGATCTTTCAATCCGATGCATATCGGTCA
TTTGGCACTGGCCAATTATCTGACAGAATACACTCCGATCGGACAGTTGT
GGTTCGTACCAAGCCCGTTGAACCCTCTAAAAAATACCCAAGAGCTGCTC
CCGTACGATCTGCGTTGCGAGCTGATAGAGCAAGCCATTCGTAAGGATAT
CCGTTTTCAAGTTCTGCGCATTGAAGAGCTGCTCCCTTCTCCTCACTACA
CGATACGGACGCTTCGTGCTCTCTCCATGCTGTATCCTCATCATCGGTTC
GCCCTCCTGATCGGGGCGGACAACTGGCAGAGCTTCGATCGATGGAAGGA
TCATCATCGGCTGATGGCCAAATACGAGCTAATCATATACCCTCGGTTCG
GCTATGAAGTAGACGATACGACGCTTCCGACCGGATGTCGATACATACAT
GATGCCCCGCGAATAGAAATCTCCTCTACCCAAATCAGGACAAGCATATT
GGAAGGAAAAGATCTACGCTATTGGCTACCTCTCCCTGAGTCTCAGGACG
TCATAGCATCTGCCCTGCAAAGTTGTCTGTCACCAAAACGC

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