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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0049 IGR0051 IGR0052 IGR0054 IGR0050 IGR0053 PG0057 czcB, - PG0056 PG0054 PG0058 czcA, - PG0055 yngK, - PG0052 PG0053 PG0057 czcB, - PG0056 PG0054 PG0058 czcA, - PG0055 yngK, - PG0052 PG0053 PG0057 czcB, - PG0056 PG0054 PG0058 czcA, - PG0055 yngK, - PG0052 PG0053


LANL Gene ID: PG0055

GenBank Locus Tag: PG0064

DNA Molecule Name:
1  

GenBank ID:
34539936

Gene Name:
czcA  

Definition:
cation efflux protein

Cellular Location:
Inner membrane, Cytoplasm [Evidence]

Gene Start:
80283

Gene Stop:
77167

Gene Length:
3117

Molecular Weight*:
113485

pI*:
5.70

Net Charge*:
-5.78

EC:
 

Functional Class:
Transport and binding; Cations  

Gene Ontology:
Biological process
  GO:0006812    cation transport

Cellular component
  GO:0016021    integral to membrane

Molecular function
  GO:0008324    cation transporter activity


Pathway: pathway table

Comment:
TIGR ID: PG0064

Proteomic Data: Proteomic Data Search
TIGR Annotationheavy metal efflux pump, CzcA family, GroupS (transport and binding proteins)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0064-0.580.077-0.940.035-0.690.029-0.940.035
LANLPG00550.670.520.620.38
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous hits in gapped BLAST to cation efflux proteins, e.g. residues 1-1019 are 59% similar to the protein in Synechocystis (D64005).

This sequence is similar to BT2039.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539936|ref|NP_904415.1|  heavy metal efflux pump, CzcA ...  1945   0.0  
 gi|53713381|ref|YP_099373.1|  CzcA family cation efflux syst...  1498   0.0  
 gi|60681633|ref|YP_211777.1|  putative cation transport rela...  1497   0.0  
 gi|153808889|ref|ZP_01961557.1|  hypothetical protein BACCAC...  1445   0.0  
 gi|53715007|ref|YP_100999.1|  AcrB/AcrD/AcrF family cation e...  1443   0.0  
 gi|29347449|ref|NP_810952.1|  cation efflux system protein, ...  1433   0.0  
 gi|156111887|gb|EDO13632.1|  hypothetical protein BACOVA_006...  1426   0.0  
 gi|156861219|gb|EDO54650.1|  hypothetical protein BACUNI_016...  1425   0.0  
 gi|150004579|ref|YP_001299323.1|  AcrB/AcrD/AcrF family cati...  1415   0.0  
 gi|150008239|ref|YP_001302982.1|  cation efflux system prote...  1392   0.0


InterPro Summary:  InterProScan

InterPro
IPR001036
Family
Acriflavin resistance protein
PR00702 [12-36]T 7.9E-32 PR00702 ACRIFLAVINRP[40-58]T 7.9E-32 PR00702 ACRIFLAVINRP[333-356]T 7.9E-32 PR00702 ACRIFLAVINRP[360-381]T 7.9E-32 PR00702 ACRIFLAVINRP[388-412]T 7.9E-32 PR00702 ACRIFLAVINRP[551-568]T 7.9E-32 PR00702 ACRIFLAVINRP ACRIFLAVINRP
PF00873 [5-1023]T 0.0 PF00873 ACR_tran ACR_tran
InterPro
IPR004763
Family
Heavy metal efflux pump CzcA
TIGR00914 [1-1039]T 0.0 TIGR00914 2A0601 2A0601
noIPR
unintegrated
unintegrated
SSF82693 [42-130]T 2.8E-22 SSF82693 SSF82693[136-326]T 3.9E-17 SSF82693 SSF82693[564-660]T 3.7999999999999997E-4 SSF82693 SSF82693 SSF82693
SSF82714 [184-268]T 1.3E-13 SSF82714 SSF82714[717-803]T 3.5E-12 SSF82714 SSF82714 SSF82714
SSF82866 [292-502]T 8.3E-40 SSF82866 SSF82866[798-1029]T 2.5999999999999998E-46 SSF82866 SSF82866 SSF82866


COGS Summary:  COGS Search
BeTs to 8 clades of COG0841
COG name: Cation efflux system protein
Functional Class: P
The phylogenetic pattern of COG0841 is -----QvCEb-hUJ--o---x
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
***** PR00702 (Acriflavin resistance protein family signature) with a combined E-value of 1.3e-36.
    PR00702A    12-36
    PR00702B    40-58
    PR00702C    333-356
    PR00702D    360-381
    PR00702E    388-412
    PR00702F    449-472
    PR00702G    474-497
    PR00702H    551-568


 ProDom Summary:  Protein Domain Search
Residues 619-850 are 40% similar to a (PROTEIN TRANSMEMBRANE EFFLUX TRANSPORT) protein domain (PD001911 which is seen in Q55935_SYNY3.

Residues 403-501 are 34% similar to a (PROTEIN CATION EFFLUX SYSTEM) protein domain (PD007644 which is seen in O25622_HELPY.

Residues 351-561 are 30% similar to a (PROTEIN MITOCHONDRION TRANSMEMBRANE OXIDOREDUCTASE NAD) protein domain (PD000148 which is seen in O51165_BORBU.

Residues 930-1019 are 46% similar to a (PROTEIN TRANSMEMBRANE MEMBRANE PUTATIVE TRANSPORT INNER) protein domain (PD000801 which is seen in Q55935_SYNY3.

Residues 513-613 are 34% similar to a (PROTEIN EFFLUX CATION SYSTEM) protein domain (PD002079 which is seen in Q9ZKN2_BBBBB.

Residues 1-248 are 39% similar to a (PROTEIN TRANSMEMBRANE EFFLUX TRANSPORT) protein domain (PD001810 which is seen in Q55935_SYNY3.

Residues 251-343 are 38% similar to a (PROTEIN TRANSMEMBRANE EFFLUX TRANSPORT) protein domain (PD002081 which is seen in Q55935_SYNY3.


Paralogs:  Local Blast Search
Residues 5-1019 are 25% similar to PG0493, a predicted cation efflux protein.

Pfam Summary:  Pfam Search
Residues 5 to 1023 (E-value = 9.5e-285) place PG0055 in the ACR_tran family which is described as AcrB/AcrD/AcrF family (PF00873)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable signal  
1  
32
non-globular  
35  
103
transmembrane  
341  
357
transmembrane  
346  
370
transmembrane  
362  
378
transmembrane  
375  
398
transmembrane  
392  
408
transmembrane  
447  
464
transmembrane  
450  
466
transmembrane  
474  
490
transmembrane  
475  
493
transmembrane  
538  
554
transmembrane  
540  
557
transmembrane  
866  
882
transmembrane  
867  
884
transmembrane  
895  
911
transmembrane  
900  
924
transmembrane  
915  
931
transmembrane  
967  
983
transmembrane  
999  
1015
transmembrane  
1003  
1020

Top PDB Hits:
-42% similar to PDB:1IWG Crystal structure of Bacterial Multidrug Efflux transporter AcrB (E_value = 1.2E_61);
-42% similar to PDB:1OY6 Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump (E_value = 1.2E_61);
-42% similar to PDB:1OY8 Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump (E_value = 1.2E_61);
-42% similar to PDB:1OY9 Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump (E_value = 1.2E_61);
-42% similar to PDB:1OYD Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump (E_value = 1.2E_61);

Gene Protein Sequence:
MLNKIIRFSLNNRLTILVASVLLMLVGTYTASNMEVDVFPDLNAPTVVVM
TEATGMAPEEVERLVTFPVETAVNGATDVRRVRSSSTTGFSIVWVEFDWG
TDIYRARQIVSEKLAVVGADLPDNVGKPTLGPQSSILGEVMIIGLTADST
SLQDLRTLADWTIRPRLLSIGGVAQVTVLGGDIKEYQILLNPERMKHYGI
TLAEVRAAVDQMNRNASGGVLYEYGNEYIICGLLSTNDAAALGKTLVKSL
DDIPIMLESVAEVRVGNKAPKLGLASERGQSAVLVTITKQPATSTLELTE
RLDRSLADLQKALPSDVKVSTDIFRQERFIENSISNVRKALYEGGIFVVI
VLFIFLMNARATIISLVTIPLSLVASFLTLKLMGLTINTMSLGGMAIAIG
SLVDDAIVDVENVYKRLRENRMKPREEQDTVLNVIFEASKEVRMPILNST
FIIIASFVPLFFLSGMEGRMLVPLGIAFIIALLASTIVALTLTPVLCSYL
LAKRKKDDSPEKEPIVAKKLKGWYGQALQWSLGNTKKVLLMTGGVLVAAL
IVFFTLGRSFLPPFNEGSFTINVSTLPGISLEESDRMGRMAEEILLSVPE
VQTVGRKTGRAELDEHALGVNVSEIEVPFVLKDRSKDEVLADIREKLKVL
PGVNIEIGQPISHRIDAMLSGTRANIAIKLFGPDLNRLFAIGNQIKTSVH
DVKGVADLNVEQQVERPQLKIVPKREMLAKYGLTPASFAEIVNVMLAGEV
VSQVYEGNRSFDLSLKVNDESRESADRIRDLIIDAGGRKIPFAYVADIVS
ASGPNTINRENVSRKIVVSANVAGRDLRSVVNDIQERIDADITLPEGYHI
EYGGQFESEQAASRTLLVTSVFFILVIFLLLFNQFRSLSQSAVSLLNLPL
ALIGGVFAIFFTGGIISIPAIIGFISLFGIATRNGMLLISRYNDLQQAGL
SPYESVLRGSLDRLNPILMTALTSGLALIPLALGGELPGNEIQSPMAKVI
LGGLFSSTILNAFIVPIMYLLTDKSYRERTFRNRQLTIE

Gene Nucleotide Sequence:  Sequence Viewer
ATGCTGAACAAGATCATTCGGTTCTCTCTGAACAACCGGCTGACCATATT
GGTAGCATCCGTACTGCTGATGCTGGTCGGCACCTATACGGCCTCCAATA
TGGAGGTGGACGTATTCCCTGACTTGAACGCTCCTACCGTCGTAGTGATG
ACGGAGGCTACCGGTATGGCACCCGAGGAAGTGGAACGCCTCGTAACCTT
CCCCGTCGAGACGGCCGTCAATGGAGCTACCGACGTGCGTCGCGTGCGCT
CGTCTTCCACTACGGGCTTCTCTATCGTTTGGGTGGAATTCGACTGGGGG
ACGGATATTTATCGTGCTCGTCAGATCGTGTCGGAAAAGCTGGCCGTGGT
CGGTGCCGATCTGCCGGACAATGTGGGCAAACCTACGCTCGGCCCCCAAT
CCTCCATCCTCGGCGAAGTCATGATTATCGGACTTACGGCCGACAGCACC
TCTCTCCAAGACCTCCGTACTTTGGCCGACTGGACGATCCGTCCGCGCTT
GCTCTCGATCGGAGGTGTGGCACAGGTGACAGTACTCGGAGGCGACATCA
AGGAATATCAGATACTGCTCAATCCCGAAAGGATGAAGCACTACGGTATC
ACGCTGGCCGAAGTACGTGCTGCCGTCGACCAAATGAACCGCAATGCATC
GGGTGGCGTACTGTATGAATACGGCAACGAATATATCATTTGCGGACTCC
TCTCCACGAACGATGCTGCCGCATTGGGTAAGACACTGGTAAAAAGTCTC
GATGATATTCCCATCATGCTCGAAAGCGTGGCAGAGGTAAGGGTGGGCAA
TAAGGCACCGAAGTTGGGCCTTGCTTCCGAGCGAGGACAATCTGCCGTAC
TCGTGACCATCACCAAACAGCCGGCGACGAGTACACTGGAGCTGACCGAA
AGGTTGGATCGCTCTCTGGCCGATCTGCAAAAGGCTCTCCCCTCCGATGT
GAAAGTGAGTACAGACATATTCCGTCAAGAGCGTTTCATCGAAAATTCTA
TCAGCAACGTACGAAAAGCTCTGTACGAAGGAGGCATATTCGTCGTCATC
GTATTATTCATTTTCCTGATGAATGCTCGTGCCACGATCATTTCGCTGGT
CACCATTCCCCTTTCGCTGGTTGCATCCTTTTTGACACTCAAACTGATGG
GACTGACCATCAATACGATGAGTCTCGGAGGTATGGCTATCGCCATCGGT
TCGCTGGTGGACGATGCCATCGTGGACGTGGAGAATGTATACAAACGCCT
GCGCGAAAACCGTATGAAGCCTCGCGAAGAACAGGACACGGTGCTCAACG
TCATATTCGAAGCCTCCAAGGAGGTGCGTATGCCGATCCTTAACTCCACC
TTTATCATTATCGCCAGCTTCGTACCGCTGTTTTTCCTCTCCGGTATGGA
GGGACGTATGCTGGTTCCGCTTGGGATCGCCTTTATCATTGCCCTTCTGG
CATCTACCATTGTAGCCCTTACGCTTACCCCCGTACTCTGTAGCTATTTG
CTGGCTAAGAGAAAGAAAGATGATTCGCCGGAAAAGGAACCCATCGTGGC
CAAGAAACTGAAAGGCTGGTACGGACAGGCCCTGCAGTGGTCTCTTGGCA
ACACGAAAAAAGTATTGCTTATGACCGGTGGTGTACTGGTGGCTGCACTT
ATCGTCTTCTTCACCCTCGGACGCAGTTTTCTGCCTCCATTCAACGAAGG
GTCGTTCACCATCAACGTAAGCACTCTACCGGGCATATCGCTGGAGGAAA
GCGACAGAATGGGGCGTATGGCAGAAGAAATCCTGCTTTCAGTCCCCGAA
GTACAGACCGTGGGGCGTAAGACGGGACGCGCCGAACTGGACGAGCACGC
ACTGGGAGTCAATGTGTCGGAAATAGAGGTGCCCTTCGTCCTCAAGGATC
GTTCCAAAGACGAAGTCCTTGCTGACATTCGCGAGAAGCTCAAAGTGCTG
CCGGGTGTGAATATCGAAATAGGCCAGCCCATTTCGCACCGCATCGATGC
CATGCTCTCGGGTACGCGCGCCAATATCGCCATCAAACTATTCGGTCCGG
ATCTGAACCGGCTGTTTGCAATCGGGAATCAGATCAAGACTTCCGTTCAC
GATGTGAAGGGAGTGGCGGATCTGAATGTGGAGCAGCAGGTGGAGCGACC
GCAACTCAAGATCGTACCGAAGCGTGAGATGCTGGCCAAATACGGACTCA
CACCGGCGAGTTTTGCCGAAATAGTCAATGTGATGCTTGCAGGAGAAGTG
GTTTCGCAGGTGTACGAAGGCAATCGTTCGTTCGATCTTTCTCTGAAGGT
GAACGATGAAAGCCGCGAGAGCGCAGACCGCATCCGAGATCTCATCATAG
ACGCCGGCGGACGGAAGATACCCTTCGCTTATGTGGCCGATATAGTGTCG
GCTTCGGGGCCGAATACGATCAACCGCGAGAACGTTTCCCGAAAAATAGT
CGTTTCAGCCAATGTGGCCGGTCGAGACCTGCGCAGCGTTGTCAATGATA
TTCAGGAAAGGATCGATGCCGATATTACGCTTCCCGAGGGCTATCATATC
GAGTATGGAGGGCAGTTCGAAAGCGAACAGGCAGCATCGCGCACCCTTCT
CGTCACCTCCGTTTTTTTCATTTTGGTGATCTTCCTGCTGCTTTTCAATC
AGTTCCGAAGTCTCTCTCAATCGGCGGTCAGCCTGCTCAACCTGCCTTTG
GCTCTTATCGGAGGTGTCTTTGCCATCTTCTTCACAGGTGGGATTATCAG
TATTCCGGCCATCATCGGCTTTATCTCCCTGTTCGGAATAGCCACGCGCA
ACGGTATGCTGCTCATTTCGCGTTACAACGATTTGCAGCAAGCAGGCCTT
TCACCATACGAAAGTGTCCTGCGAGGTTCGCTGGATCGTCTGAATCCGAT
CCTGATGACAGCCCTTACATCCGGGCTCGCTCTTATACCGCTGGCACTGG
GGGGCGAACTTCCGGGCAACGAGATCCAGAGTCCGATGGCGAAGGTCATA
CTCGGGGGATTGTTTTCCTCCACCATTCTCAACGCTTTTATCGTTCCGAT
TATGTATCTGCTGACCGACAAAAGCTATCGAGAAAGGACGTTTCGAAATC
GACAACTAACAATCGAA

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