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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0066 IGR0073 IGR0072 IGR0071 IGR0065 IGR0067 IGR0069 IGR0068 IGR0070 PG0076 PG0082 PG0081 PG0080 PG0074 PG0078 dps, - PG0079 sda,sdh, - PG0072 PG0077 melA, - PG0073 PG0076 PG0082 PG0081 PG0080 PG0074 PG0078 dps, - PG0079 sda,sdh, - PG0072 PG0077 melA, - PG0073 Type: tandem, Name: tan33 - 241 Type: tandem, Name: tan34 - 242 Type: tandem, Name: tan84 - 292 PG0076 PG0082 PG0081 PG0080 PG0074 PG0078 dps, - PG0079 sda,sdh, - PG0072 PG0077 melA, - PG0073


LANL Gene ID: PG0077

GenBank Locus Tag: PG0088

DNA Molecule Name:
1  

GenBank ID:
34539958

Gene Name:


Definition:
hypothetical zinc protease

Cellular Location:
Cytoplasm, Extracellular [Evidence]

Gene Start:
103415

Gene Stop:
104629

Gene Length:
1215

Molecular Weight*:
46392

pI*:
6.70

Net Charge*:
-3.06

EC:
 

Functional Class:
Uncategorized  

Gene Ontology:

Pathway: pathway table

Secondary Evidence:
Chen,N.Y., Jiang,S.Q., Klein,D.A. and Paulus,H. 1993. Organization and nucleotide sequence of the Bacillus subtilis diaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthase. J. Biol. Chem. 268 (13): 9448-9465. PubMed: 8098035.


Comment:
Zinc protease requires divalent cations for activity. In Bacillus subtilis, this protein belongs to the peptidase family M16, also known as the insulinase family (gi: 1176567).


TIGR ID: PG0088

Human Oral Microbiome Database:
View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Numerous hits with gapped blast to putative zinc proteases: i.e., residues 6-403 of PG0077 are 33% similar to residues 5-401 of YmxG, a hypothetical zinc protease from B. subtilis (1176567).

This protein is similar to CT806, a predicted insulinase family/protease III, and to BT3308.


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539958|ref|NP_904437.1|  peptidase, M16 family [Porphyr...   815   0.0  
 gi|150009484|ref|YP_001304227.1|  putative zinc protease Ymx...   405   e-111
 gi|154490034|ref|ZP_02030295.1|  hypothetical protein PARMER...   390   e-107
 gi|156861945|gb|EDO55376.1|  hypothetical protein BACUNI_010...   367   e-100
 gi|53711465|ref|YP_097457.1|  putative zinc protease YmxG [B...   358   4e-97
 gi|60679735|ref|YP_209879.1|  putative peptidase [Bacteroide...   358   5e-97
 gi|29348717|ref|NP_812220.1|  putative zinc protease ymxG [B...   357   1e-96
 gi|153807212|ref|ZP_01959880.1|  hypothetical protein BACCAC...   351   6e-95
 gi|156111633|gb|EDO13378.1|  hypothetical protein BACOVA_009...   343   1e-92
 gi|150003837|ref|YP_001298581.1|  putative zinc protease [Ba...   341   6e-92


InterPro Summary:  InterProScan

InterPro
IPR007863
Domain
Peptidase M16, C-terminal
PF05193 [165-340]T 7.00000734129907E-30 PF05193 Peptidase_M16_C Peptidase_M16_C
InterPro
IPR011765
Domain
Peptidase M16, N-terminal
PF00675 [13-160]T 1.89999859865843E-27 PF00675 Peptidase_M16 Peptidase_M16
noIPR
unintegrated
unintegrated
G3DSA:3.30.830.10 [2-197]T 6.49997950541775E-54 G3DSA:3.30.830.10 G3DSA:3.30.830.10[222-394]T 9.499968559308541E-44 G3DSA:3.30.830.10 G3DSA:3.30.830.10 G3DSA:3.30.830.10
PTHR11851 [28-397]T 1.0999918447139803E-90 PTHR11851 PTHR11851 PTHR11851
SSF63411 [1-191]T 1.2E-45 SSF63411 SSF63411[216-404]T 6.0999999999999995E-40 SSF63411 SSF63411 SSF63411


COGS Summary:  COGS Search
BeTs to 10 clades of COG0612
COG name: Predicted Zn-dependent peptidases
Functional Class: R
The phylogenetic pattern of COG0612 is ----YQvCEBrhUJ--o---x
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
***** IPB001431 (Insulinase family (Peptidase family M16)) with a combined E-value of 1.3e-15.
    IPB001431A    43-56
    IPB001431B    76-90
    IPB001431C    178-190


 ProDom Summary:  Protein Domain Search
Residues 231-403 are 32% similar to a (PROTEASE PROCESSING PROTEIN PEPTIDASE PRECURSOR) protein domain (PD001445 which is seen in O86835_STRCO.

Residues 6-190 are 37% similar to a (PROTEASE PROTEIN METALLOPROTEASE) protein domain (PD000718 which is seen in YMXG_BACSU.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 13 to 160 (E-value = 1.7e-30) place PG0077 in the Peptidase_M16 family which is described as Insulinase (Peptidase family M16) (PF00675)
Residues 165 to 340 (E-value = 1.3e-32) place PG0077 in the Peptidase_M16_C family which is described as Peptidase M16 inactive domain (PF05193)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-46% similar to PDB:1HR6 YEAST MITOCHONDRIAL PROCESSING PEPTIDASE (E_value = 2.1E_29);
-46% similar to PDB:1HR7 YEAST MITOCHONDRIAL PROCESSING PEPTIDASE BETA-E73Q MUTANT (E_value = 4.7E_29);
-46% similar to PDB:1HR8 YEAST MITOCHONDRIAL PROCESSING PEPTIDASE BETA-E73Q MUTANT COMPLEXED WITH CYTOCHROME C OXIDASE IV SIGNAL PEPTIDE (E_value = 4.7E_29);
-46% similar to PDB:1HR9 YEAST MITOCHONDRIAL PROCESSING PEPTIDASE BETA-E73Q MUTANT COMPLEXED WITH MALATE DEHYDROGENASE SIGNAL PEPTIDE (E_value = 4.7E_29);
-44% similar to PDB:1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN (E_value = 9.1E_25);

Gene Protein Sequence:
MDYQLYTLPSGLHVVYKPHAGEVTYAGFAIGVGTRHESSRHHGLAHLTEH
MLFKGTSLRNSLQIIRRMEEVGAELNAFTEKESTYVYCIFPKAHFNRATN
LLFDIVQHSRFPEEELTKEKTVVIDEIDSYRDNPSELIFDEFENILFRHH
PLGHNILGTEASVSRITGQIGRNFLRRHYRPDNMIFFLAGEADLSDWPLN
PAEKVSIRNTDGTPLHTLREGFLPRTIRRHKDTYQHHILMGGPAYSLHDD
RRIPLSLLNNILGGPGMNSRLNLSLREEHGYVYNVESNYTPYSDTGVFNI
YLGCAPRYAEAAMELVRKELRYLIEHPLSPIELESAKRQFKGQLIVSADN
KESTFLSLGKSMLLYGKYDPLSDIFHRIDAITSDRLREIAAEVLNPDSML
TLIYC

Gene Nucleotide Sequence:  Sequence Viewer
ATGGATTATCAACTATACACGCTGCCGAGCGGTTTGCATGTGGTATATAA
ACCGCATGCGGGCGAAGTTACATACGCCGGCTTTGCCATAGGCGTCGGCA
CACGCCACGAAAGCTCGCGGCATCATGGATTGGCTCATCTGACGGAACAC
ATGCTCTTCAAAGGCACCAGCCTGCGCAATAGCCTTCAGATCATTCGTCG
CATGGAAGAGGTCGGTGCCGAGCTTAATGCTTTCACCGAGAAAGAATCCA
CCTATGTGTACTGCATCTTTCCGAAAGCGCACTTCAACCGTGCCACCAAT
CTCCTTTTCGATATTGTACAGCATAGCCGATTCCCGGAAGAAGAATTGAC
CAAAGAGAAAACCGTTGTTATCGACGAAATCGATTCTTATCGAGACAATC
CCTCGGAACTTATATTCGACGAATTCGAGAATATCCTTTTCCGTCATCAT
CCTCTCGGACATAACATTCTCGGCACAGAGGCTTCTGTATCACGCATCAC
GGGACAAATAGGTCGTAACTTCCTCCGTCGCCACTACCGGCCGGACAATA
TGATCTTCTTCCTGGCCGGAGAAGCAGACCTGTCCGATTGGCCCCTTAAT
CCGGCCGAGAAGGTCTCCATCCGTAATACCGATGGTACTCCTCTCCATAC
CCTCAGAGAAGGCTTTCTGCCGCGTACCATCAGACGGCACAAGGATACCT
ACCAGCATCACATCCTCATGGGCGGTCCGGCGTATTCGCTCCACGACGAC
AGACGCATTCCGCTAAGTCTGCTTAATAATATCCTCGGAGGGCCGGGTAT
GAACTCCCGGCTCAATCTCTCACTGCGTGAAGAGCATGGCTATGTCTATA
ACGTAGAGAGCAATTACACGCCCTATTCCGATACGGGAGTCTTCAATATC
TACCTCGGCTGCGCTCCCCGATATGCGGAAGCAGCCATGGAGCTTGTCAG
AAAAGAGTTGCGCTATTTGATCGAACACCCTCTTTCTCCGATAGAACTGG
AATCTGCCAAGCGACAGTTCAAAGGGCAGCTCATCGTGTCGGCTGACAAT
AAGGAGTCCACATTCCTTTCATTGGGCAAGAGTATGCTCCTCTATGGCAA
ATACGATCCCCTTTCGGATATTTTCCATCGTATCGATGCCATTACCTCCG
ATCGGCTCCGTGAGATTGCGGCCGAAGTGCTGAATCCTGACAGCATGCTT
ACACTGATTTATTGT

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