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Record: 1 of 1 MiniMap

LANL Gene ID: PG0084GenBank Locus Tag: PG0095DNA Molecule Name: 1 GenBank ID: 34539964Gene Name: mutS Definition: DNA mismatch repair proteinCellular Location: Cytoplasm [Evidence]Gene Start: 114853Gene Stop: 112181Gene Length: 2673Molecular Weight*: 100676pI*: 6.20Net Charge*: -11.14EC: Functional Class: DNA metabolism; DNA replication, recombination and repair Gene Ontology: Biological process GO:0006298 mismatch repair Molecular function GO:0003684 damaged DNA binding GO:0005524 ATP binding GO:0030983 mismatched DNA bindingPathway: pathway tableSecondary Evidence: LeClerc JE, Li B, Payne WL, Cebula TA. 1996. High mutation frequencies among Escherichia coli and Salmonella pathogens. Science 274(5290): 1208-11. PubMed: 8895473. Schlensog,V. and Bock,A. 1991. The Escherichia coli fdv gene probably encodes mutS and is located at minute 58.8 adjacent to the hyc-hyp gene cluster. J. Bacteriol. 173 (23): 7414-7415. PubMed: 1938937.Comment: The MutS protein is responsible for repair of mismatched bases. It does this in part through an ATPase domain. TIGR ID: PG0095Proteomic Data: Proteomic Data Search

TIGR Annotation		DNA mismatch repair protein MutS, GroupF (DNA metabolism)
ORF #		PG-PP/PG-PPC1				PG-PP/PG-PPC2
		Spectral Count		Peptide Intensity		Spectral Count		Peptide Intensity
		Pro	qVal	Pro	qVal	Pro	qVal	Pro	qVal
TIGR	PG0095	0.86	0.036	1.35	0.0018	2.67	4.5e-07	1.35	0.0018
LANL	PG0084	1.81		2.55		6.37		12.19
Consensus		SP1		IP1		SP2		IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer Blast Summary: PSI-Blast Search Several hits in gapped BLAST to DNA mismatch repair proteins, e.g. residues 8-845 are 37% similar to the mutS enzyme from E.coli (embCAB43497.1). This protein is similar to CT792, a predicted mismatch repair protein, and to BT3121. Top Blast Hits: Updated monthly Click here to view the entire PsiBlast results. gi|34539964|ref|NP_904443.1| DNA mismatch repair protein [P... 1768 0.0 gi|150003763|ref|YP_001298507.1| putative DNA mismatch repa... 1191 0.0 gi|154493322|ref|ZP_02032642.1| hypothetical protein PARMER... 1185 0.0 gi|150009585|ref|YP_001304328.1| putative DNA mismatch repa... 1177 0.0 gi|156109869|gb|EDO11614.1| hypothetical protein BACOVA_028... 1158 0.0 gi|156862724|gb|EDO56155.1| hypothetical protein BACUNI_001... 1156 0.0 gi|60683780|ref|YP_213924.1| DNA mismatch repair protein [B... 1153 0.0 gi|53715862|ref|YP_101854.1| DNA mismatch repair protein [B... 1149 0.0 gi|153807044|ref|ZP_01959712.1| hypothetical protein BACCAC... 1149 0.0 gi|29348530|ref|NP_812033.1| DNA mismatch repair protein [B... 1144 0.0InterPro Summary: InterProScan InterPro IPR000432 Domain DNA mismatch repair protein MutS, C-terminal PD001263 MutS_C PF00488 MutS_V SM00534 MUTSac PS00486 DNA_MISMATCH_REPAIR_2 InterPro IPR005748 Family MutS 1 protein TIGR01070 mutS1 InterPro IPR007695 Domain DNA mismatch repair protein MutS, N-terminal PF01624 MutS_I InterPro IPR007696 Domain MutS III PF05192 MutS_III SM00533 MUTSd InterPro IPR007860 Domain MutS II PF05188 MutS_II InterPro IPR007861 Domain MutS IV PF05190 MutS_IV noIPR unintegrated unintegrated G3DSA:1.10.1420.10 G3DSA:1.10.1420.10 G3DSA:3.30.420.110 G3DSA:3.30.420.110 G3DSA:3.40.1170.10 G3DSA:3.40.1170.10 G3DSA:3.40.50.300 G3DSA:3.40.50.300 PTHR11361 PTHR11361 PTHR11361:SF34 PTHR11361:SF34 SSF48334 SSF48334 SSF52540 SSF52540 SSF53150 SSF53150 SSF55271 SSF55271 COGS Summary: COGS Search BeTs to 10 clades of COG0249 COG name: MutS-like ATPases involved in mismatch repair, family 2 Functional Class: L The phylogenetic pattern of COG0249 is ----Yqvceb-h----olinx Number of proteins in this genome belonging to this COG is 2 Blocks Summary: Blocks Search ***** IPB000432 (DNA mismatch repair protein MutS family) with a combined E-value of 5e-80. IPB000432A 297-321 IPB000432B 614-645 IPB000432C 654-702 IPB000432D 728-738 IPB000432E 761-794 ProDom Summary: Protein Domain Search Residues 550-794 are 50% similar to a (PROTEIN DNA REPAIR ATP-BINDING DNA-BINDING MISMATCH MUTS) protein domain (PD001263 which is seen in MUTS_SYNY3. Residues 8-188 are 45% similar to a (REPAIR DNA PROTEIN MISMATCH) protein domain (PD136848 which is seen in MUTS_THEMA. Residues 230-547 are 35% similar to a (PROTEIN REPAIR DNA ATP-BINDING DNA-BINDING MISMATCH MUTS) protein domain (PD002590 which is seen in MUTS_THEMA. Paralogs: Local Blast Search Residues 291-796 are 21% similar to residues 24-528 of PG0350, a predicted MUS2 enzyme. Residues 340-738 are 23% similar to residues 37-395 of PG0954. Pfam Summary: Pfam Search Residues 8 to 120 (E-value = 8.4e-59) place PG0084 in the MutS_I family which is described as MutS domain I (PF01624) Residues 128 to 254 (E-value = 4.9e-22) place PG0084 in the MutS_II family which is described as MutS domain II (PF05188) Residues 262 to 564 (E-value = 2.3e-107) place PG0084 in the MutS_III family which is described as MutS domain III (PF05192) Residues 428 to 519 (E-value = 8.4e-35) place PG0084 in the MutS_IV family which is described as MutS family domain IV (PF05190) Residues 567 to 804 (E-value = 9.1e-139) place PG0084 in the MutS_V family which is described as MutS domain V (PF00488) Structural Feature(s): Feature Type Start Stop coil-coil 492 533 Top PDB Hits: -60% similar to PDB:1E3M THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:T MISMATCH (E_value = 1.8E_159); -60% similar to PDB:1OH5 THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH (E_value = 1.8E_159); -60% similar to PDB:1OH6 THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH (E_value = 1.8E_159); -60% similar to PDB:1OH7 THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH (E_value = 1.8E_159); -60% similar to PDB:1OH8 THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE (E_value = 1.8E_159); Gene Protein Sequence: MAKPVVETPLMRQYFQIKQKHPDAILLFRVGDFYETFSEDAIVASEILGI TLTRRANGAAQFVELAGFPHHALDTYLPKLVRAGKRVAICDQLEDPKKTK TLVKRGITELVTPGVSTNDNVLSHKENNFLAAVSCGKEVFGISLLDISTG EFMAGQGNADYVEKLLTNYRPKEILVERSERSRFNDLFHWSGFIFDMEDW AFSSENNRLRVLKHFDLKSLKGFGLEELSMAVTAAGAVLNYLDLTQHHQL QHITSLSRLDENRYVRLDKFTVRSLELLSPMNEGGKSLLDIIDHTITPMG ARRIRQWIVFPLKDPARIQARQRVVEFFFRHPEERAIIAEHLTEIGDLER LVTKGAMGRISPREMVQLRVALQALEPIKEVCTHADEENLRTLGGKLELC KELRDKILREVMPDAPAALGRGPVIAHGVDATLDELRALAYSGKDYLIKL QQQEIERTGIPSLKVAYNNVFGYYIEVRNTHKDKVPAEWIRKQTLVSAER YITEELKEYEAKILGAEEKIAALEGQLYALLVAELQRYVAPLQQDSQAVA SLDCLLSFAESARRYRFICPVVDESFTIDIKAGRHPVIEQQLPADEPYIA NDIYLDTDRQQVIIVTGPNMSGKSALLRQTALISLMAQIGSFVPAESARI GMVDSIFTRVGASDNISMGESTFMVEMQEASNILNNLTPRSLVLFDELGR GTSTYDGISIAWSIVEYIHDNPKAHPRTLFATHYHELNELEGQLDRVHNF NVSAREVDGKMLFLRKLEPGGSAHSFGIQVARLGGMPHHIVQRATDILHR LEQEREKIEEEEPKTKDTKRGPSEKVKNASPTLPRDEKGRSIDGYQLSFF QLDDPVLSQIREEILDLNIDNLTPLEALNKLNDIKRILRGY Gene Nucleotide Sequence: Sequence Viewer ATGGCAAAGCCTGTGGTAGAAACGCCTTTGATGCGCCAATACTTTCAGAT CAAGCAAAAACACCCTGATGCTATCCTGCTCTTCAGGGTGGGAGATTTCT ACGAAACATTTTCGGAGGATGCCATCGTGGCTTCCGAGATCCTGGGGATA ACGCTGACACGGCGTGCCAACGGAGCTGCCCAGTTTGTCGAATTGGCCGG CTTTCCTCATCATGCGTTGGATACCTATCTGCCCAAATTGGTACGAGCCG GCAAGCGCGTGGCCATATGCGACCAACTGGAAGATCCGAAAAAGACCAAA ACGCTGGTCAAACGCGGTATTACCGAACTGGTCACTCCCGGCGTATCGAC CAACGACAATGTACTCTCTCATAAGGAGAACAATTTCCTTGCAGCCGTCT CCTGCGGCAAAGAGGTCTTCGGTATTTCTCTTCTGGACATATCCACCGGC GAATTTATGGCCGGACAAGGCAATGCCGACTATGTGGAAAAACTCCTGAC CAACTACCGCCCGAAGGAAATCCTCGTGGAACGGTCGGAGCGGTCTCGCT TCAACGACCTCTTCCACTGGAGCGGATTTATCTTCGATATGGAAGACTGG GCTTTCTCCTCGGAGAACAATCGACTACGCGTACTCAAGCACTTTGACCT GAAAAGCCTCAAAGGTTTCGGGCTGGAAGAGCTTTCGATGGCAGTAACGG CAGCCGGAGCCGTACTGAACTATCTCGATCTGACACAGCACCATCAGCTA CAACACATCACATCGCTGAGCCGACTGGATGAAAACCGGTATGTACGCTT GGATAAGTTCACCGTCCGAAGCCTTGAATTGCTTAGCCCGATGAACGAGG GAGGCAAGAGTCTGCTCGACATCATCGACCATACGATAACGCCTATGGGA GCAAGGCGTATACGACAGTGGATCGTATTCCCACTCAAGGACCCTGCACG CATACAAGCCCGACAGCGAGTGGTGGAGTTTTTCTTCCGACATCCTGAAG AGCGAGCCATCATTGCCGAACATCTGACAGAGATAGGCGACTTGGAACGT TTGGTGACGAAAGGCGCCATGGGACGCATTTCTCCGCGAGAAATGGTACA ACTACGTGTCGCCCTGCAAGCACTCGAACCGATCAAGGAAGTATGTACCC ATGCAGACGAAGAGAATCTGCGCACACTGGGGGGAAAGTTGGAGCTGTGC AAGGAACTACGCGACAAGATATTGCGTGAGGTGATGCCCGATGCTCCGGC CGCTCTCGGTCGCGGCCCCGTCATCGCACATGGCGTCGATGCCACGCTCG ACGAACTGCGTGCACTGGCATACAGCGGCAAAGACTATCTGATCAAGCTA CAGCAGCAGGAGATAGAGCGAACGGGAATACCCAGTCTCAAAGTAGCTTA TAACAATGTGTTCGGCTACTATATCGAAGTCCGCAACACGCACAAGGACA AGGTACCGGCCGAGTGGATCCGCAAGCAAACACTCGTCAGTGCCGAACGG TATATTACGGAAGAGCTGAAAGAGTACGAAGCAAAAATACTCGGAGCCGA AGAGAAAATAGCAGCCCTCGAAGGACAGCTGTACGCCTTGCTTGTAGCCG AACTGCAGCGATACGTGGCACCTCTCCAACAGGACAGTCAAGCGGTGGCT TCTCTGGATTGTCTCCTCTCCTTTGCCGAGTCGGCACGCCGCTACAGATT TATCTGCCCTGTAGTGGACGAGAGCTTTACCATCGACATCAAAGCGGGCC GCCACCCCGTCATCGAACAGCAGCTACCGGCCGATGAACCTTATATCGCC AACGATATTTATTTGGACACAGACCGCCAGCAAGTCATCATCGTCACCGG CCCCAATATGAGCGGCAAGTCCGCCCTGCTCAGGCAGACGGCCCTTATCT CTCTGATGGCACAGATAGGCTCTTTCGTACCGGCCGAAAGTGCACGTATC GGCATGGTGGACAGCATTTTCACGCGGGTGGGAGCTTCGGACAACATCTC CATGGGCGAATCCACTTTCATGGTCGAAATGCAAGAAGCTTCCAATATTC TGAACAATCTCACGCCACGCAGTCTGGTACTGTTCGACGAATTAGGACGG GGTACCAGCACCTATGACGGCATCTCCATAGCCTGGTCTATCGTGGAGTA CATCCATGACAATCCCAAGGCACACCCCCGGACTCTCTTCGCCACACATT ATCACGAACTGAACGAGCTGGAAGGGCAACTCGATCGGGTACACAACTTC AATGTATCGGCTCGCGAAGTGGACGGCAAGATGCTCTTCCTTCGCAAATT GGAGCCGGGCGGCAGTGCACACAGCTTCGGTATTCAAGTAGCCCGTCTCG GCGGTATGCCACACCATATCGTACAGCGAGCCACAGACATCCTGCATCGT CTCGAACAAGAAAGGGAGAAAATAGAGGAAGAGGAGCCAAAAACCAAAGA CACCAAACGAGGCCCTTCCGAAAAGGTGAAAAATGCGTCGCCCACGCTTC CTCGGGACGAAAAAGGCAGGAGCATCGACGGTTATCAGCTTAGCTTCTTT CAGCTCGATGATCCCGTCTTGTCCCAAATCAGAGAGGAGATCCTCGATCT GAACATCGACAACCTCACCCCCTTGGAGGCCCTCAATAAGCTGAACGACA TCAAACGAATCCTCCGCGGATAC Los Alamos National Laboratory • Est 1943 Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy

`Feature Type`	`Start`	`Stop`
`coil-coil`	`492`	`533`