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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0095 IGR0089 IGR0091 IGR0090 IGR0094 IGR0093 IGR0092 IGR0096 PG0109 PG0108 PG0110 PG0106 PG0107 wecG, - PG0104 hemH,hemZ, - PG0112 PG0103 weeA, - PG0105 PG0102 PG0109 PG0108 PG0110 PG0106 PG0107 wecG, - PG0104 hemH,hemZ, - PG0112 PG0103 weeA, - PG0105 PG0102 PG0108 PG0110 PG0111 PG0111 PG0109 PG0106 PG0107 wecG, - PG0104 hemH,hemZ, - PG0112 PG0103 weeA, - PG0105 PG0102 PG0101 PG0101


LANL Gene ID: PG0105

GenBank Locus Tag: PG0120

DNA Molecule Name:
1  

Genomic Island ID:
2

GenBank ID:
34539985

 Gene Name:
weeA  

 Definition:
UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase)

 Cellular Location:
Cytoplasm [Evidence]

 Gene Start:
143144

Gene Stop:
144301

Gene Length:
1158

Molecular Weight*:
43344

pI*:
6.40

Net Charge*:
-2.47

EC:
5.1.3.14  

 Functional Class:
Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides  

 Gene Ontology:
Biological process
  GO:0006047    UDP-N-acetylglucosamine metabolic process
  GO:0009103    lipopolysaccharide biosynthetic process

Molecular function
  GO:0008761    UDP-N-acetylglucosamine 2-epimerase activity


 Pathway: pathway table
Aminosugars metabolism

 Comment:
TIGR ID: PG0120

 Proteomic Data: Proteomic Data Search
TIGR AnnotationUDP-N-acetylglucosamine 2-epimerase, GroupC (cell envelope)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG01200.680.0381.560.000361.455.1e-051.560.00036
LANLPG01051.602.952.733.28
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous hits in gapped BLAST to acetylglucosamine epimerases, e.g. residues 1-382 are 69% similar to the UDP-GlcNAc 2-epimerase from Bacteroides fragilis (AF125164).

This sequence is similar to BT0601.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34539985|ref|NP_904464.1|  UDP-N-acetylglucosamine 2-epim...   766   0.0  
 gi|63107067|emb|CAI94414.1|  hypothetical protein [Porphyrom...   753   0.0  
 gi|63107071|emb|CAI94417.1|  hypothetical protein [Porphyrom...   752   0.0  
 gi|60680300|ref|YP_210444.1|  putative UDP-GlcNAc 2-epimeras...   592   e-167
 gi|154494102|ref|ZP_02033422.1|  hypothetical protein PARMER...   583   e-165
 gi|150003270|ref|YP_001298014.1|  putative UDP-GlcNAc 2-epim...   582   e-165
 gi|156860507|gb|EDO53938.1|  hypothetical protein BACUNI_025...   582   e-164
 gi|53712392|ref|YP_098384.1|  UDP-GlcNAc 2-epimerase [Bacter...   582   e-164
 gi|154491610|ref|ZP_02031236.1|  hypothetical protein PARMER...   580   e-164
 gi|150006717|ref|YP_001301460.1|  putative UDP-GlcNAc 2-epim...   576   e-162


InterPro Summary:  InterProScan

InterPro
IPR003331
Family
UDP-N-acetylglucosamine 2-epimerase
PTHR18964:SF2 [27-382]T 0.0 PTHR18964:SF2 Epimerase_2 Epimerase_2
PF02350 [22-383]T 0.0 PF02350 Epimerase_2 Epimerase_2
TIGR00236 [2-386]T 0.0 TIGR00236 wecB wecB
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.2000 [3-226]T 1.5999883531365902E-75 G3DSA:3.40.50.2000 G3DSA:3.40.50.2000 G3DSA:3.40.50.2000
PTHR18964 [27-382]T 0.0 PTHR18964 PTHR18964 PTHR18964
SSF53756 [1-382]T 0.0 SSF53756 SSF53756 SSF53756


COGS Summary:  COGS Search
BeTs to 8 clades of COG0381
COG name: UDP-N-acetylglucosamine 2-epimerase
Functional Class: M
The phylogenetic pattern of COG0381 is -mtk--Vceb----------x
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** BP03764 (2-EPIMERASE PROTEIN UDP-N-ACETYLGLUCOSAMINE ISOMERASE) with a combined E-value of 1.6e-132.
    BP03764A    3-35
    BP03764B    41-68
    BP03764C    104-138
    BP03764D    140-174
    BP03764F    254-301
    BP03764G    302-328
    BP03764H    344-380
    BP03764F    250-297


 ProDom Summary:  Protein Domain Search
Residues 1-44 are 70% similar to a (2-EPIMERASE UDP-N-ACETYLGLUCOSAMINE) protein domain (PD003764 which is seen in Q9ZFT1_STRPN.

Residues 56-382 are 56% similar to a (2-EPIMERASE UDP-N-ACETYLGLUCOSAMINE) protein domain (PD004092 which is seen in EPSC_BURSO.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 22 to 383 (E-value = 2.8e-170) place PG0105 in the Epimerase_2 family which is described as UDP-N-acetylglucosamine 2-epimerase (PF02350)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-72% similar to PDB:1F6D THE STRUCTURE OF UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE FROM E. COLI. (E_value = 7.8E_119);
-72% similar to PDB:1VGV Crystal structure of UDP-N-acetylglucosamine_2 epimerase (E_value = 7.8E_119);
-66% similar to PDB:1O6C Crystal structure of UDP-N-acetylglucosamine 2-epimerase (E_value = 1.5E_101);
-58% similar to PDB:1V4V Crystal Structure Of UDP-N-Acetylglucosamine 2-Epimerase From Thermus Thermophilus HB8 (E_value = 2.7E_71);

Gene Protein Sequence:
MKKVMLVFGTRPEAIKMAPLVKEFQARASEFDTIVCVTGQHREMLKQVLE
LFDIKPDYDLEIMKEGQDLYDVTTRVLLGMREVLKKTKPDVVLVHGDTTT
STAAALAAFYQQIPVGHVEAGLRTHNIYSPWPEEMNRQLTGRMATYHFAP
TELSRDNLLAEGIATDRIFITGNTVIDALQQVVTRVKGNADLRNQVSRKL
LQFGYDVNRLEAGRRLVLITGHRRENFGEGFLNICRAIQTLSKRFPEVDF
VYPMHLNPNVRKPIREIFGDNLGGLDNLFFIEPLEYLQFVTLMDRSSIVL
TDSGGIQEEAPGLGKPVLVMRDTTERPEAVKAGTVKLVGTDYNQIVDNVE
KLLTDNAAYAEMSRANNPYGDGKACSYIADALTRCI

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAAAAGTGATGTTGGTCTTCGGGACGAGACCCGAAGCGATCAAGAT
GGCTCCGCTGGTGAAGGAATTTCAAGCGAGAGCAAGTGAGTTTGATACCA
TTGTCTGTGTGACGGGTCAGCATAGAGAGATGCTCAAGCAAGTGCTGGAG
CTATTTGATATCAAGCCCGATTATGACTTGGAGATCATGAAGGAGGGGCA
GGATCTCTATGACGTAACTACACGTGTGCTGTTGGGTATGCGTGAAGTAC
TCAAGAAGACAAAGCCCGATGTAGTACTCGTACACGGCGATACGACTACA
AGTACTGCCGCTGCATTGGCTGCTTTCTATCAACAGATTCCGGTAGGACA
TGTGGAGGCAGGGCTTCGCACGCACAACATTTACAGCCCATGGCCGGAAG
AGATGAACCGTCAGCTCACCGGTAGGATGGCTACCTATCACTTTGCTCCT
ACGGAATTGAGTCGGGACAATTTACTTGCAGAAGGGATTGCTACAGATCG
TATATTTATTACAGGAAATACAGTAATCGATGCTCTACAACAAGTCGTTA
CACGAGTTAAGGGTAATGCCGATTTGCGAAATCAAGTGTCTCGAAAGCTA
CTTCAATTTGGATATGATGTGAATCGTTTAGAGGCTGGGCGTAGACTTGT
TCTTATCACAGGGCATCGCAGAGAAAACTTTGGCGAAGGATTCCTTAATA
TCTGCCGTGCTATTCAAACTCTTAGCAAGCGTTTCCCGGAGGTAGACTTT
GTTTATCCCATGCACCTTAACCCCAATGTGCGTAAGCCTATTCGCGAGAT
CTTCGGCGATAACCTTGGAGGCTTGGATAATCTCTTTTTTATTGAGCCGC
TGGAGTATTTGCAGTTTGTTACGCTCATGGATCGTTCGTCCATTGTTCTG
ACTGATAGTGGAGGTATTCAGGAAGAAGCTCCAGGGTTAGGCAAACCTGT
ATTGGTAATGCGAGATACTACGGAGCGTCCCGAAGCGGTGAAAGCAGGAA
CCGTGAAACTTGTAGGGACAGATTATAATCAAATCGTCGACAATGTCGAA
AAACTACTGACAGACAACGCCGCATATGCCGAAATGAGCAGAGCCAATAA
TCCGTACGGTGACGGAAAAGCATGCTCATATATAGCGGATGCTCTTACTC
GATGCATT

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