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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0154 IGR0147 IGR0146 IGR0152 IGR0151 IGR0149 IGR0153 IGR0150 IGR0148 PG0181 PG0181.1 PG0184 PG0183 hemD, - PG0185 PG0177 PG0176 PG0182 PG0179 ISPg3, - PG0178 PG0175 PG0180 PG0181 PG0181.1 PG0184 PG0183 hemD, - PG0185 PG0177 PG0176 PG0182 PG0179 ISPg3, - PG0178 PG0175 PG0180 Type: tandem, Name: tan36 - 244 Type: IS element, Name: ISPg1 fragment - 3 Type: IS element, Name: ISPg3 - 5 Type: tandem, Name: tan35 - 243 PG0181.1 PG0183 hemD, - PG0185 PG0183.1 PG0184 PG0181 PG0183.1 PG0177 PG0182 PG0179 ISPg3, - PG0178 PG0175 PG0180 PG0176


LANL Gene ID: PG0180

GenBank Locus Tag: PG0196

DNA Molecule Name:
1  

GenBank ID:
34540052

Gene Name:


Definition:
probable zinc protease/ 106 kDa immunoreactive protein

Cellular Location:
Periplasm, Cytoplasm, Extracellular [Evidence]

Gene Start:
233043

Gene Stop:
235865

Gene Length:
2823

Molecular Weight*:
105653

pI*:
5.20

Net Charge*:
-16.56

EC:
3.4.99.-  

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0006508    proteolysis

Molecular function
  GO:0004222    metalloendopeptidase activity


Pathway: pathway table

Primary Evidence:
Ross,B.C., Barr,I., Patterson,M., Agius,C., Rothel,L., Margetts,M., Hocking,D. and Webb,E.
Porphyromonas gingivalis polypeptides and nucleic acids
Patent: Australia (AU 98/01023)-PCT 10-DEC-1998;
CSL Ltd;
45 Poplar Road;
R&D;
Parkville, Victoria;
Australia;

Comment:
TIGR ID: PG0196

Proteomic Data: Proteomic Data Search
TIGR Annotationpeptidase, M16 family, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0196-0.030.19-0.060.2-0.540-0.060.2
LANLPG01800.980.960.691.01
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
PG0180 corresponds to the previously sequenced gb|AAD38979, a predicted 106 kDa immunoreactive protein.

Numerous hits in gapped BLAST to zinc peptidase sequences, e.g. residues 38-88 are 25% similar to an enzyme from Arabidopsis thaliana (AB013392). See also PQQL_ECOLI.

This sequence is similar to BT4320.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|5059344|gb|AAD38979.1|AF153767_1  immunoreactive 106 kDa ...  1835   0.0  
 gi|34540052|ref|NP_904531.1|  peptidase, M16 family [Porphyr...  1805   0.0  
 gi|154493392|ref|ZP_02032712.1|  hypothetical protein PARMER...   935   0.0  
 gi|150009659|ref|YP_001304402.1|  putative zinc protease [Pa...   880   0.0  
 gi|150006118|ref|YP_001300862.1|  putative zinc protease [Ba...   843   0.0  
 gi|60680484|ref|YP_210628.1|  putative zinc protease [Bacter...   828   0.0  
 gi|29349728|ref|NP_813231.1|  putative zinc protease [Bacter...   828   0.0  
 gi|53712310|ref|YP_098302.1|  putative zinc protease [Bacter...   827   0.0  
 gi|156107515|gb|EDO09260.1|  hypothetical protein BACOVA_051...   806   0.0  
 gi|153807629|ref|ZP_01960297.1|  hypothetical protein BACCAC...   799   0.0


InterPro Summary:  InterProScan

InterPro
IPR001431
Binding_site
Peptidase M16, zinc-binding site
PS00143 [67-90]T 8.0E-5 PS00143 INSULINASE INSULINASE
InterPro
IPR007863
Domain
Peptidase M16, C-terminal
PF05193 [207-395]T 6.69999687625957E-26 PF05193 Peptidase_M16_C[690-872]T 3.4999946686394896E-25 PF05193 Peptidase_M16_C Peptidase_M16_C
InterPro
IPR011765
Domain
Peptidase M16, N-terminal
PF00675 [46-168]T 3.4999946686394897E-19 PF00675 Peptidase_M16 Peptidase_M16
noIPR
unintegrated
unintegrated
G3DSA:3.30.830.10 [22-258]T 2.6000051765774302E-48 G3DSA:3.30.830.10 G3DSA:3.30.830.10[528-742]T 1.7999975402237803E-27 G3DSA:3.30.830.10 G3DSA:3.30.830.10 G3DSA:3.30.830.10
PTHR11851 [62-906]T 0.0 PTHR11851 PTHR11851 PTHR11851
PTHR11851:SF63 [62-906]T 0.0 PTHR11851:SF63 PTHR11851:SF63 PTHR11851:SF63
SSF63411 [25-263]T 2.0E-37 SSF63411 SSF63411[333-492]T 1.2E-6 SSF63411 SSF63411[526-737]T 6.3E-23 SSF63411 SSF63411[785-941]T 6.1999999999999994E-12 SSF63411 SSF63411 SSF63411


COGS Summary:  COGS Search
BeTs to 10 clades of COG0612
COG name: Predicted Zn-dependent peptidases
Functional Class: R
The phylogenetic pattern of COG0612 is ----YQvCEBrhUJ--o---x
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
***** IPB001431 (Insulinase family (Peptidase family M16)) with a combined E-value of 6.3e-16.
    IPB001431A    77-90
    IPB001431B    114-128
    IPB001431C    220-232


 ProDom Summary:  Protein Domain Search
Residues 374-724 are 22% similar to a (PROTEASE ZINC PROBABLE PQQL) protein domain (PD043014 which is seen in O51486_BORBU.

Residues 38-235 are 42% similar to a (PROTEASE PROTEIN METALLOPROTEASE HYDROLASE PROCESSING) protein domain (PD000718 which is seen in PQQL_ECOLI.

Residues 310-734 are 20% similar to a (CHLOROPLAST PROCESSING ENZYME METALLOENDOPEPTIDASE) protein domain (PD044088 which is seen in O48870_ARATH.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 46 to 190 (E-value = 5.8e-21) place PG0180 in the Peptidase_M16 family which is described as Insulinase (Peptidase family M16) (PF00675)
Residues 207 to 395 (E-value = 3.6e-28) place PG0180 in the Peptidase_M16_C family which is described as Peptidase M16 inactive domain (PF05193)
Residues 690 to 872 (E-value = 2.4e-27) place PG0180 in the Peptidase_M16_C family which is described as Peptidase M16 inactive domain (PF05193)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable signal  
1  
22
non-globular  
437  
566
coil-coil  
862  
889

Top PDB Hits:
-47% similar to PDB:1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE (E_value = 6.5E_14);
-47% similar to PDB:1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE (E_value = 6.5E_14);
-47% similar to PDB:1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone (E_value = 6.5E_14);
-47% similar to PDB:1L0N native structure of bovine mitochondrial cytochrome bc1 complex (E_value = 6.5E_14);
-47% similar to PDB:1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 (E_value = 6.5E_14);

Gene Protein Sequence:
MELKRFLSLGLLLVGFIPMKLSAQQAQPLPTDPAVRVGKLDNGLTYFIRH
NENPKDRADFFIAQKVGSILEEDSQSGLAHFLEHMAFNGTKNFPGKNLIN
YLETIGVRFGQNLNASTGFDKTEYTIMDVPTTRQGIIDSCLLILHDWSNN
ITLDGHEIDEERGVIQEEWRARRDANLRMFEAILAKAMPGNKYAERMPIG
LMDVVLNFKHDELRNYYKKWYRPDLQGLVIVGDIDVDYVENKIKELFKDV
PAPVNPAERIYTPVEDNDEPIVAIATDAEATTTQLSISFKSDPTPQEVRG
SIFGLVEDYMKQVITTAVNERLSEITHKPNAPFLSAGAFFSNFMYITQTK
DAFNFVATVREGEAEKAMNALVAEIESLRQFGITKGEYDRARTNVLKRYE
NQYNERDKRKNNAYANEYSTYFTDGGYIPGIEVEYQTVNAFAPQVPLEAF
NQAIAQMIDPVKNAVVTLTGPSKAEAKIPSEADFLAAFKAARQQKVEAKK
DEVSDQKLMEKAPKAGKIVSEKKDQKFGTTELTLSNGIKVYLKKTDFKSN
EILMSALSPGGILSGKHAPNQSVMNSFMNVGGLGNFDAIQLDKVLTGRSA
SVSPSLSLLSEGLSGKTTVEDMETFFQLIYLQMTANRKDPEAFKATQEKL
YNNLKNQEANPMAALMDSIRHTMYGDNPMMKPMKAADVEKVNYDQVMAFY
NERFADAGDFMFFFIGNLDEAKMKPLIETYLASLPNLKRGDKMNKAQVPA
ARSGKIDCKFEKEMDTPSTTIFDVVSGNVEYTLKNSLLLEVFSAVMDQVY
TATVREKEGGAYSVAAFGGLEQYPQPKALMQIYFPTDPARAEEMNAIVFA
ELEKLAKEGPNVEYFKKTIENLNKQHKESLRENRFWLEAMKASFFEGNDF
ITDYESVLNGLTPAELQKFAADLLKQQNRVVVMMAPVAKAQ

Gene Nucleotide Sequence:  Sequence Viewer
ATGGAATTGAAAAGATTTTTATCACTTGGTCTTCTGCTTGTGGGATTCAT
TCCGATGAAGCTTTCTGCCCAACAGGCTCAGCCACTCCCTACAGATCCGG
CTGTTCGTGTCGGTAAGTTGGACAACGGATTGACTTATTTCATCCGTCAC
AACGAGAACCCGAAAGATCGTGCGGATTTCTTTATCGCACAAAAGGTAGG
TTCTATTCTTGAAGAAGATAGCCAGTCCGGTTTGGCTCACTTCTTGGAAC
ACATGGCTTTCAACGGTACGAAGAACTTCCCCGGTAAGAACTTGATCAAC
TATCTCGAAACGATCGGTGTACGTTTCGGTCAGAACCTGAACGCTTCTAC
CGGATTCGACAAGACGGAATATACGATAATGGATGTGCCGACTACACGTC
AGGGAATCATCGACTCCTGCTTGCTTATCCTGCATGATTGGAGTAACAAT
ATTACCCTCGACGGGCATGAGATCGACGAGGAGCGCGGTGTGATCCAGGA
AGAGTGGCGTGCTCGTCGCGATGCCAACCTTCGTATGTTCGAGGCTATAC
TTGCCAAGGCTATGCCGGGTAATAAATATGCAGAACGCATGCCCATCGGT
CTGATGGACGTCGTGCTCAACTTCAAGCATGATGAGCTGCGCAACTATTA
TAAGAAATGGTATCGTCCCGACCTGCAAGGTCTGGTGATCGTGGGAGATA
TCGATGTGGACTATGTGGAGAACAAGATCAAAGAACTCTTCAAGGACGTT
CCTGCTCCCGTGAATCCAGCAGAGCGTATCTATACGCCGGTAGAGGACAA
CGATGAGCCTATCGTAGCCATTGCTACCGATGCTGAGGCTACTACCACGC
AGCTCTCCATCAGCTTCAAGAGCGACCCCACTCCTCAAGAAGTGCGAGGA
TCGATATTCGGACTTGTGGAAGACTATATGAAACAGGTGATCACTACAGC
CGTGAATGAGCGTCTGTCCGAGATTACTCACAAGCCTAACGCTCCTTTCC
TCAGTGCAGGAGCTTTCTTCTCTAACTTCATGTACATCACCCAGACTAAG
GACGCATTCAATTTTGTTGCCACGGTTCGTGAGGGTGAAGCGGAGAAAGC
GATGAACGCATTGGTGGCAGAGATAGAAAGCCTCCGTCAGTTCGGTATCA
CCAAAGGCGAATACGATCGTGCACGCACGAATGTGCTCAAGCGATACGAG
AATCAATACAACGAAAGAGACAAGCGTAAGAACAATGCTTATGCCAATGA
ATACTCCACCTACTTCACCGATGGCGGCTATATCCCGGGTATTGAGGTGG
AATATCAGACGGTGAATGCTTTTGCTCCTCAGGTTCCTCTGGAAGCATTC
AATCAGGCTATTGCCCAAATGATCGATCCGGTGAAGAATGCTGTCGTTAC
CCTCACCGGTCCTTCAAAGGCTGAAGCCAAGATTCCGAGCGAAGCAGACT
TCCTCGCTGCTTTCAAAGCTGCTCGTCAGCAGAAAGTAGAAGCCAAGAAA
GACGAAGTCTCCGACCAAAAATTGATGGAGAAAGCTCCTAAGGCCGGAAA
GATCGTTTCCGAGAAGAAAGATCAGAAGTTCGGTACCACGGAACTTACCC
TTAGCAATGGCATCAAAGTATACCTCAAGAAGACCGATTTCAAATCAAAC
GAAATCCTGATGAGTGCTCTCAGCCCGGGTGGTATCCTCTCCGGAAAGCA
TGCTCCCAACCAATCTGTGATGAATTCGTTCATGAACGTGGGTGGCTTGG
GCAACTTCGATGCTATCCAGCTGGATAAGGTGCTGACAGGTCGCTCTGCT
TCCGTATCTCCCTCTTTGTCTCTGCTCAGTGAAGGTCTTTCGGGCAAAAC
GACTGTAGAAGATATGGAAACTTTCTTCCAGTTGATCTATCTCCAAATGA
CTGCTAACCGCAAGGATCCCGAAGCGTTCAAGGCCACACAGGAAAAGTTG
TACAATAACTTGAAAAATCAGGAAGCCAACCCGATGGCTGCGCTTATGGA
CTCTATCCGTCATACCATGTACGGCGATAATCCGATGATGAAACCCATGA
AAGCTGCTGACGTGGAGAAAGTAAATTACGATCAGGTAATGGCTTTCTAC
AATGAGCGATTCGCTGATGCCGGCGACTTTATGTTCTTCTTTATCGGTAA
TCTGGATGAAGCCAAGATGAAGCCATTGATCGAAACTTATCTTGCTTCAT
TGCCCAACCTCAAGCGTGGCGATAAGATGAATAAGGCTCAGGTACCGGCT
GCCCGTTCGGGAAAGATCGATTGCAAGTTCGAGAAGGAAATGGATACTCC
TTCGACTACTATATTCGATGTCGTGTCCGGAAATGTGGAATATACGCTCA
AGAACAGTCTCCTGCTGGAAGTCTTCTCAGCCGTAATGGATCAGGTGTAC
ACGGCTACCGTTCGCGAGAAGGAAGGCGGTGCATACAGTGTGGCTGCATT
CGGCGGTCTCGAGCAATATCCTCAGCCCAAGGCTCTGATGCAGATCTATT
TCCCCACGGATCCTGCTCGTGCCGAGGAAATGAATGCTATCGTTTTTGCT
GAGTTGGAGAAGCTTGCCAAGGAGGGCCCCAATGTGGAATACTTTAAGAA
GACTATCGAAAACCTGAATAAGCAGCACAAAGAAAGTCTGCGTGAGAATC
GTTTCTGGCTCGAAGCCATGAAGGCGTCTTTCTTCGAAGGAAATGACTTC
ATCACAGACTACGAATCCGTACTGAACGGTCTTACTCCTGCTGAATTGCA
AAAGTTTGCGGCAGACCTCTTGAAGCAGCAGAATCGGGTTGTTGTCATGA
TGGCTCCTGTTGCAAAGGCTCAA

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