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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap tRNA-Tyr-1 IGR0293 IGR0296 IGR0297.1 IGR0295 IGR0297 IGR0298 IGR0294 PG0347 rs21, - PG0351 PG0352 PG0349 PG0348 uvrB, - PG0346 hexA,mutS2, - PG0350 PG0347 rs21, - PG0351 PG0352 PG0349 PG0348 uvrB, - PG0346 hexA,mutS2, - PG0350 PG0347 rs21, - PG0351 PG0352 PG0349 PG0348 uvrB, - PG0346 hexA,mutS2, - PG0350


LANL Gene ID: PG0349

GenBank Locus Tag: PG0383

DNA Molecule Name:
1  

GenBank ID:
34540211

Gene Name:


Definition:
zinc metalloprotease

Cellular Location:
Inner membrane, Cytoplasm [Evidence]

Gene Start:
414906

Gene Stop:
416222

Gene Length:
1317

Molecular Weight*:
48660

pI*:
9.10

Net Charge*:
4.60

EC:
 

Functional Class:
Uncategorized  

Gene Ontology:
Biological process
  GO:0006508    proteolysis

Molecular function
  GO:0004222    metalloendopeptidase activity
  GO:0005515    protein binding
  GO:0008237    metallopeptidase activity
  GO:0008270    zinc ion binding


Pathway: pathway table

Comment:
TIGR ID: PG0383

Proteomic Data: Proteomic Data Search
TIGR Annotationmembrane-associated zinc metalloprotease, putative, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG03834.074.3e-057.811.7e-112.190.000137.811.7e-11
LANLPG034916.80223.714.553.88
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST; e.g. residues 12-436 are 27% similar to gb|AAG07037.1|AE004785_1 conserved hypothetical protein of Pseudomonas aeruginosa, residues 12-436 are 27% similar to gb|AAF95397.1| conserved hypothetical protein of Vibrio cholerae, residues 12-436 are 29% similar to emb|CAB83400.1| putative integral membrane protein of Neisseria meningitidis Z2491, residues 5-434 are 27% similar to gb|AAC65573.1| zinc protease, putative of Treponema pallidum.

This seqeunce is similar to BT2001.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540211|ref|NP_904690.1|  membrane-associated zinc metal...   865   0.0  
 gi|53714983|ref|YP_100975.1|  membrane-associated zinc metal...   439   e-121
 gi|60682950|ref|YP_213094.1|  putative protease [Bacteroides...   439   e-121
 gi|150007137|ref|YP_001301880.1|  membrane-associated zinc m...   438   e-121
 gi|156861170|gb|EDO54601.1|  hypothetical protein BACUNI_015...   433   e-120
 gi|154495069|ref|ZP_02034074.1|  hypothetical protein PARMER...   432   e-119
 gi|156111181|gb|EDO12926.1|  hypothetical protein BACOVA_014...   428   e-118
 gi|153809485|ref|ZP_01962153.1|  hypothetical protein BACCAC...   425   e-117
 gi|29347411|ref|NP_810914.1|  membrane-associated zinc metal...   424   e-117
 gi|150004211|ref|YP_001298955.1|  membrane-associated zinc m...   420   e-116


InterPro Summary:  InterProScan

InterPro
IPR001478
Domain
PDZ/DHR/GLGF
SM00228 [211-278]T 1.1000000000000101E-4 SM00228 PDZ PDZ
PS50106 [205-278]T 0.0 PS50106 PDZ PDZ
SSF50156 [111-207]T 5.1E-6 SSF50156 PDZ[214-288]T 1.3E-13 SSF50156 PDZ PDZ
InterPro
IPR006025
Binding_site
Peptidase M, neutral zinc metallopeptidases, zinc-binding site
PS00142 [19-28]? 0.0 PS00142 ZINC_PROTEASE ZINC_PROTEASE
InterPro
IPR008915
Family
Peptidase M50
PF02163 [10-433]T 6.00001679190146E-56 PF02163 Peptidase_M50 Peptidase_M50
noIPR
unintegrated
unintegrated
G3DSA:2.30.42.10 [223-286]T 1.49999977583351E-5 G3DSA:2.30.42.10 G3DSA:2.30.42.10 G3DSA:2.30.42.10
PTHR22939 [238-288]T 1.79999951654676E-6 PTHR22939 PTHR22939 PTHR22939
PTHR22939:SF12 [238-288]T 1.79999951654676E-6 PTHR22939:SF12 PTHR22939:SF12 PTHR22939:SF12


COGS Summary:  COGS Search
BeTs to 13 clades of COG0750
COG name: Predicted membrane-associated Zn-dependent proteases 1
Functional Class: M
The phylogenetic pattern of COG0750 is AmtK-qvCebrhUj--olinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 12-111 are 39% similar to a (PROTEIN PROTEASE CDS TRANSMEMBRANE) protein domain (PD004820 which is seen in O67776_AQUAE.

Residues 364-438 are 41% similar to a (PROTEIN CDS TRANSMEMBRANE D15) protein domain (PD005718 which is seen in O84075_CHLTR.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 10 to 433 (E-value = 2.4e-48) place PG0349 in the Peptidase_M50 family which is described as Peptidase family M50 (PF02163)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable signal  
1  
16
transmembrane  
5  
25
transmembrane  
107  
123
transmembrane  
109  
128
transmembrane  
299  
316
transmembrane  
366  
383
transmembrane  
372  
388
transmembrane  
388  
405
transmembrane  
410  
426
transmembrane  
413  
430

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
MIVFLIKAAQLILAFAILVFVHELGHYFFARLFRVRVDKFYLFFDWGGAI
FRYKPKRSETEFGIGWLPLGGYCKINGMIDESMDTEYLQQEPKPYEFRSR
PTWQRLLIMLGGVLFNFLLALVIYSGIVLQWGSMRMPSDRISSGMAFSSV
AQEAGFQNDDIILAVDGRPVDALASGFMRSVIQARQVEVLRQGRREIVHV
PHDMMKRVLKANSGFMSIQVPFVIDSVMPQGTAYACQLKAGDSITAVNGK
LMPDASDVIGAIRSHAGDTIALSIARAGEELTITLPVDTGGLIGVSLRPL
DAIYTIDHIRYSLFEAIPAGIAQGMGTMRSYVSDMKYVFTKEGAGQIGGF
GTLGSLFPASWNWPQFWAMTALLSIMLAVMNILPIPALDGGHILFLLIEI
ITRRKVGQEVLIRAQLIGMAILILLVLYANGNDLLRAFR

Gene Nucleotide Sequence:  Sequence Viewer
ATGATAGTTTTCCTCATTAAAGCTGCGCAGTTGATCCTCGCATTCGCCAT
TCTGGTTTTCGTCCATGAATTGGGACATTACTTTTTTGCTCGTCTCTTCC
GAGTCAGGGTGGACAAGTTCTACCTTTTCTTCGATTGGGGAGGTGCCATC
TTCCGTTACAAGCCCAAACGGAGCGAAACGGAATTCGGTATCGGTTGGCT
TCCTCTCGGTGGCTATTGCAAGATCAACGGGATGATAGACGAATCCATGG
ATACCGAGTACTTGCAGCAAGAGCCGAAACCTTATGAATTTCGCAGCCGA
CCGACATGGCAGCGGCTTCTGATCATGCTGGGGGGAGTGCTGTTCAATTT
CCTGTTGGCTCTTGTCATCTATTCCGGTATTGTCCTGCAATGGGGTAGTA
TGCGGATGCCTTCGGATCGTATCAGTTCGGGCATGGCCTTCTCCTCCGTG
GCACAGGAGGCCGGTTTTCAAAACGATGATATTATCCTCGCTGTGGATGG
CCGGCCGGTGGATGCTTTGGCTTCAGGGTTCATGCGGTCGGTGATTCAGG
CTCGCCAAGTGGAAGTCCTGAGACAAGGCCGGCGAGAGATCGTACATGTT
CCGCACGATATGATGAAGCGTGTGCTCAAAGCCAACAGCGGCTTTATGTC
CATACAGGTGCCGTTCGTCATCGATAGCGTCATGCCCCAAGGGACGGCTT
ATGCCTGTCAGCTGAAAGCGGGCGACAGTATCACTGCCGTAAATGGCAAG
TTGATGCCTGATGCAAGCGATGTGATCGGAGCCATTCGCAGCCATGCAGG
CGATACCATAGCCCTGTCCATAGCCCGAGCAGGCGAAGAGCTGACTATAA
CGCTGCCGGTAGATACCGGCGGACTTATCGGAGTGAGCCTCCGACCGTTG
GATGCCATCTATACCATCGATCATATCCGATATTCGCTATTCGAAGCCAT
ACCGGCCGGAATAGCACAAGGTATGGGCACCATGCGCAGCTACGTAAGCG
ACATGAAGTACGTCTTCACCAAAGAAGGGGCAGGACAGATAGGTGGCTTC
GGGACATTGGGCAGCCTTTTCCCGGCCTCTTGGAACTGGCCTCAATTCTG
GGCTATGACGGCACTTCTCTCCATCATGCTGGCCGTCATGAACATTCTGC
CCATACCGGCATTGGATGGAGGACATATTCTCTTTCTTCTTATTGAAATC
ATTACCCGCAGGAAAGTCGGTCAGGAAGTCCTTATCCGTGCGCAATTGAT
CGGGATGGCTATTCTGATTCTTCTCGTTCTCTATGCCAATGGCAATGACT
TGCTCAGGGCTTTTCGC

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