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Record: 1 of 1 MiniMap

LANL Gene ID: PG0376GenBank Locus Tag: PG0411DNA Molecule Name: 1 GenBank ID: 34540234Gene Name: PG57 Definition: possible outer membrane proteinCellular Location: Extracellular, Outer membrane, Cytoplasm [Evidence]Gene Start: 446641Gene Stop: 449415Gene Length: 2775Molecular Weight*: 103629pI*: 4.30Net Charge*: -61.46EC: Functional Class: Cell envelope Gene Ontology: Biological process GO:0009405 pathogenesisPathway: pathway tablePrimary Evidence: See href="http://linker.lanl.gov/readonly/oragen/bacteria/pgin/hemagglutinin/summ_hemag.htm">Proteases/Hemagglutinin Analysis Ross BC, Czajkowski L, Hocking D, Margetts M, Webb E, Rothel L, Patterson M, Agius C, Camuglia S, Reynolds E, Littlejohn T, Gaeta B, Ng A, Kuczek ES, Mattick JS, Gearing D, Barr IG, Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis, Vaccine 2001 Jul 20;19(30): 4135-42, PMID: 11457538.Comment: Ross, et al.(2001) select PG0376 as one of fifteen vaccine candidate antigens, based on in vitro and in vivo laboratory studies of 120 candidates screened by bioinformatics techniques from the whole W50 genome. TIGR ID: PG0411Proteomic Data: Proteomic Data Search

TIGR Annotation		hemagglutinin, putative, GroupD (cellular processes)
ORF #		PG-PP/PG-PPC1				PG-PP/PG-PPC2
		Spectral Count		Peptide Intensity		Spectral Count		Peptide Intensity
		Pro	qVal	Pro	qVal	Pro	qVal	Pro	qVal
TIGR	PG0411	-0.15	0.2	-0.27	0.14	0.77	0.022	-0.27	0.14
LANL	PG0376	0.90		0.83		1.71		2.70
Consensus		SP1		IP1		SP2		IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer Blast Summary: PSI-Blast Search Previously sequenced and submitted to GenBank as gb|AAG24228.1| (AY007522), a putative outer membrane protein PG57 from strain W50, P.gingivalis. All significant hits are to P.gingivalis domains, e.g. Residues 312 to 742 share 34% identity and residues 597 to 729 share 47% identity with gb|AAB60809.1| (U75366), a lysine-specific cysteine proteinase in Porphyromonas gingivalis. Residues 312 to 742 share 34% identity with emb|CAA68897.1| (Y07618), a TonB-linked adhesin in Porphyromonas gingivalis. Residues 312 to 742 share 34% identity with gb|AAB17128.1| (U41807), hemagglutinin A in Porphyromonas gingivalis. There are several other matches to lysine-specific cysteine proteinase porphypain in P. gingivalis. Top Blast Hits: Updated monthly Click here to view the entire PsiBlast results. gi|34540234|ref|NP_904713.1| hemagglutinin, putative [Porph... 1863 0.0 gi|1514621|emb|CAA68897.1| TonB-linked adhesin [Porphyromon... 246 4e-63 gi|2182812|gb|AAB60809.1| lysine-specific cysteine proteina... 242 8e-62 gi|1314326|gb|AAB06565.1| porphypain 240 4e-61 gi|3869077|dbj|BAA34341.1| 130k-HMGD [Porphyromonas gingiva... 239 5e-61 gi|45593253|gb|AAS68176.1| Lys-gingipain [Porphyromonas gin... 239 8e-61 gi|6225493|sp|Q51845|HAGA2_PORGI Hemagglutinin A precursor ... 238 1e-60 gi|38605638|sp|P59915|HAGA1_PORGI Hemagglutinin A precursor 238 2e-60 gi|2738803|gb|AAC26523.1| lysine specific cysteine protease... 238 2e-60 gi|34541453|ref|NP_905932.1| hemagglutinin protein HagA [Po... 237 3e-60InterPro Summary: InterProScan InterPro IPR003961 Domain Fibronectin, type III SM00060 FN3 InterPro IPR008957 Domain Fibronectin, type III-like fold SSF49265 FN_III-like InterPro IPR011628 Domain Cleaved adhesin PF07675 Cleaved_Adhesin COGS Summary: COGS Search No hit to the COGs database. Blocks Summary: Blocks Search No significant hit to the Blocks database. ProDom Summary: Protein Domain Search Residues 578-725 are 40% similar to a (PROTEASE PRECURSOR SIGNAL HEMAGGLUTININ THIOL REPEAT) protein domain (PD001858 which is seen in P96967_PORGI. Paralogs: Local Blast Search Residues 312-742 share ~35% identity with four domains of PG1602, a hemagglutinin/adhesin precursor; hagA: residues 232-678, residues 691-1130, residues 1143-1582, residues 1595-2056. Residues 47-464 share ~33% identity with the same four domains of PG1602: residues 232-678, residues 688-1130, residues 1140-1582, residues 1592-2031. Residues 580-742 share 38% identity with two of these domains of PG1602: residues 691-886, residues 1143-1338. Residues 42-200 share ~35% identity with four domains of PG1602: residues 502-678, residues 954-1130, residues 1406-1582, residues 1833-2063. The same domains mentioned above show similarity to multiple domains in: PG1164, tonB linked outer membrane receptor, PG1605, a porphypain polyprotein, PG1768, a arginine-specific cysteine proteinase, gingipain R1, PG1606, a hemagglutinin-related protein (to a lesser degree). Pfam Summary: Pfam Search No significant hits to the Pfam 11.0 database Structural Feature(s): Feature Type Start Stop cleavable signal 1 24 Top PDB Hits: No significant hits to the PDB database (E-value < E-10). Gene Protein Sequence: MAIMMKSIVFRAFLTILLSWAAITNPTAQEISGMNASCLAAPAQPDTILY ESFENGPVPNGWLEIDADADGATWGSPSGSFSVPYGHNGLCTYSHIRSGI STAGNYLITPNIEGAKRVKYWVCNQYSTNPEHYAVMVSTTGTAIEDFVLL FDDSITGKPTPLVWRRRIVDLPEGTKYIAWRHYKVTDSHTEFLKLDDVTV YRSIEGPEPATDFTVINIGQNVGRLTWNYPEDYQPEGKGNEELQLSGYNI YANGTLLAQIKDVSILEYVDSTYSLRDNPLQVEYCVTAVYDESIESSTVC GTLHYATDAILYENFENGPVPNGWLVIDADGDGFSWGHYLNAYDAFPGHN GGHCSLSASYVPGIGPVTPDNYLITPKVEGAKRVKYWVSTQDANWAAEHY AVMASTTGTAVGDFVILFEETMTAKPTGAWYERTINLPEGTKYIAWRHYN CTDIYFLKLDDITVFGTPASEPEPVTDFVVSLIENNKGRLKWNYPNGYEP DKTDDKDPLQLAGYNIYANGSLLVHIQDPTVLEYIDETYSSRDDQVEVEY CVTAVYNDNIESQSVCDKLIYDSQSDIILYEGFEAGSIPEGWLLIDADGD NVNWDYYPWTMYGHDSEKCIASPSYLPMIGVLTPDNYLVTPRLEGAKLVK YWVSAQDAVYSAEHYAVMVSTTGTAVEDFVLLFEETMTAKANGAWYERTI TLPAGTKYIAWRHYDCTDMFFLLLDDITVYRSTETVPEPVTDFVVSLIEN NKGRLKWNYPNGYEPDKTDDKKPLQLTGYNIYANGSLLVHIQDPTVLEYI DETYSSRDGQVEMEYCVTAVYNDNIESQSVCDKLNYTITSLDNIQSDTSL KIYPNPASYVVRIEGLSRSKSTIELYNALGICILREETHSEKTEIDVSRL NDGVYLIKVVGGNKTTTEKVEIKRP Gene Nucleotide Sequence: Sequence Viewer ATGGCTATCATGATGAAAAGTATTGTTTTTAGAGCATTTCTAACGATTTT GCTCTCGTGGGCAGCGATCACGAATCCGACTGCTCAAGAGATCTCAGGCA TGAATGCATCCTGTCTGGCTGCTCCGGCTCAACCGGATACTATCTTATAT GAAAGTTTTGAGAATGGACCTGTTCCCAATGGCTGGCTTGAGATAGATGC TGATGCTGATGGTGCCACTTGGGGAAGCCCATCAGGCTCTTTCTCTGTAC CTTACGGACACAATGGCCTTTGCACCTACTCCCATATACGTTCCGGTATC TCAACAGCGGGCAACTATCTGATTACACCCAATATAGAAGGAGCCAAACG GGTCAAGTACTGGGTATGCAATCAGTATAGTACCAATCCGGAACATTACG CAGTAATGGTATCGACAACGGGGACTGCCATTGAAGACTTTGTTTTGTTG TTTGATGATTCCATAACAGGGAAACCGACTCCTCTTGTATGGCGTAGACG AATCGTGGACTTACCGGAAGGGACCAAATATATTGCATGGCGACATTACA AAGTCACCGACTCACACACAGAATTCTTGAAATTGGATGATGTCACTGTG TATAGGTCGATCGAAGGGCCCGAACCTGCTACCGACTTCACAGTAATCAA TATTGGTCAGAATGTGGGACGATTGACTTGGAACTATCCGGAGGATTATC AACCGGAAGGAAAGGGGAATGAAGAGTTGCAGCTTAGCGGCTACAACATC TATGCGAACGGTACACTACTGGCACAAATAAAAGATGTCTCCATACTGGA GTATGTGGACAGCACTTACTCTTTGCGAGACAATCCCTTGCAAGTGGAGT ACTGCGTTACAGCCGTTTACGATGAAAGCATAGAATCTTCGACCGTATGT GGCACGCTGCATTACGCCACGGATGCCATCCTTTATGAAAATTTTGAGAA TGGACCTGTTCCCAATGGTTGGCTTGTGATAGACGCTGATGGAGATGGAT TTAGCTGGGGACACTATTTGAATGCATACGACGCTTTTCCCGGCCATAAT GGAGGCCATTGCTCCTTGTCGGCTTCTTATGTTCCGGGTATAGGCCCGGT GACTCCCGACAACTATCTGATTACCCCCAAGGTTGAAGGAGCCAAACGTG TCAAGTACTGGGTAAGCACGCAGGATGCCAATTGGGCAGCGGAACATTAC GCGGTGATGGCTTCGACAACGGGGACTGCTGTCGGAGATTTCGTCATATT GTTCGAAGAAACCATGACAGCGAAGCCGACCGGCGCATGGTATGAAAGAA CCATCAACTTACCTGAAGGGACTAAATACATCGCATGGCGGCATTACAAC TGTACCGATATATATTTCTTGAAGTTGGACGATATCACTGTATTCGGGAC TCCTGCATCAGAGCCCGAACCTGTTACCGATTTCGTTGTCTCGCTTATTG AAAACAACAAGGGACGATTAAAGTGGAATTATCCTAACGGCTACGAACCC GATAAGACTGATGATAAAGACCCATTGCAGCTTGCCGGCTACAATATCTA TGCAAACGGCTCGCTCCTTGTTCACATACAAGACCCGACTGTTTTGGAGT ATATCGATGAGACTTATTCTTCACGAGACGATCAGGTGGAAGTGGAATAT TGTGTCACTGCCGTTTATAACGACAATATCGAGTCCCAATCGGTTTGCGA TAAGCTGATTTATGATTCTCAATCGGACATTATCTTATATGAAGGCTTTG AGGCCGGAAGTATTCCTGAAGGCTGGTTGTTGATTGATGCTGATGGCGAC AATGTTAATTGGGACTATTATCCTTGGACTATGTATGGACATGACAGTGA GAAGTGTATTGCATCCCCTTCGTACTTACCGATGATTGGCGTTTTAACTC CGGATAACTATTTGGTTACACCCAGACTCGAAGGAGCCAAGCTTGTCAAG TATTGGGTAAGTGCGCAAGATGCTGTTTATTCGGCTGAGCATTATGCTGT GATGGTTTCTACTACGGGAACTGCTGTTGAAGATTTTGTCCTCTTGTTCG AAGAGACAATGACCGCTAAGGCTAACGGTGCATGGTATGAGCGAACTATT ACATTGCCTGCAGGAACAAAATATATTGCCTGGCGGCATTATGATTGCAC CGATATGTTTTTCTTGCTCTTGGATGACATTACGGTTTATCGTTCTACTG AGACTGTTCCCGAGCCTGTTACTGATTTCGTTGTCTCGCTTATTGAGAAT AACAAGGGTCGCCTGAAATGGAATTATCCTAACGGCTACGAACCCGATAA GACTGATGATAAAAAACCATTGCAGCTTACCGGCTACAACATCTATGCAA ATGGCTCGCTCCTTGTTCACATACAAGACCCGACTGTTTTGGAGTATATC GATGAGACTTATTCTTCACGAGACGGTCAGGTGGAAATGGAATATTGTGT CACTGCCGTTTATAACGACAATATCGAGTCCCAATCGGTTTGCGATAAGC TGAACTATACTATCACATCCTTGGATAATATTCAATCTGATACAAGCTTG AAAATATATCCTAATCCGGCATCGTATGTGGTAAGGATAGAGGGATTGAG TCGGAGCAAGTCGACAATCGAGTTGTATAATGCGCTGGGAATTTGCATAT TAAGGGAAGAGACTCATTCAGAGAAAACGGAAATCGATGTTTCACGTCTC AATGACGGAGTCTACTTGATTAAAGTAGTCGGTGGAAATAAAACAACAAC CGAAAAGGTAGAGATAAAGAGGCCG Los Alamos National Laboratory • Est 1943 Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy

`Feature Type`	`Start`	`Stop`
`cleavable signal`	`1`	`24`