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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0321 IGR0319 IGR0318 IGR0320 IGR0323 IGR0324 IGR0322 PG0387 clpP, - PG0384 PG0386 PG0385 clpX, - PG0382 PG0380 PG0379 recQ, - PG0381 PG0389 PG0387 clpP, - PG0384 PG0386 PG0385 clpX, - PG0382 PG0380 PG0379 recQ, - PG0381 PG0389 PG0387 clpP, - PG0384 PG0386 PG0385 clpX, - PG0382 PG0380 PG0379 recQ, - PG0381 PG0388 PG0389 PG0388


LANL Gene ID: PG0382

GenBank Locus Tag: PG0417

DNA Molecule Name:
1  

GenBank ID:
34540240

Gene Name:
clpX  

Definition:
ATP-dependent ClpX-related protease

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
458714

Gene Stop:
457482

Gene Length:
1233

Molecular Weight*:
46201

pI*:
6.30

Net Charge*:
-4.03

EC:
 

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0015031    protein transport
  GO:0019538    protein metabolic process

Molecular function
  GO:0000166    nucleotide binding
  GO:0005515    protein binding
  GO:0005524    ATP binding
  GO:0008270    zinc ion binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity
  GO:0046983    protein dimerization activity


Pathway: pathway table

Comment:
TIGR ID: PG0417

Proteomic Data: Proteomic Data Search
TIGR AnnotationATP-dependent Clp protease, ATP-binding subunit ClpX, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0417-0.360.16-0.760.040.350.22-0.760.04
LANLPG03820.780.591.270.69
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits to ATP-dependent Clp proteinase (protease) ATP-binding subunit proteins in gapped BLAST; e.g. residues 9-393 are 54% similar to gb|AAG05191.1|AE004606_5 ATP-dependent Clp protease ATP-binding subunit ClpX of Pseudomonas aeruginosa, residues 1-385 are 56% similar to gb|AAC07316.1 ATP-dependent protease ATPase subunit clpX of Aquifex aeolicus, 4-385 are 55% similar to dbj|BAB06771.1| ATP-dependent Clp protease ATP-binding subunit (class III heat-shock protein) of Bacillus halodurans.

This sequence is similar to BT3843.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540240|ref|NP_904719.1|  ATP-dependent protease ATP-bin...   813   0.0  
 gi|150008999|ref|YP_001303742.1|  ATP-dependent Clp protease...   586   e-166
 gi|153809071|ref|ZP_01961739.1|  hypothetical protein BACCAC...   584   e-165
 gi|156112200|gb|EDO13945.1|  hypothetical protein BACOVA_003...   584   e-165
 gi|156859572|gb|EDO53003.1|  hypothetical protein BACUNI_030...   578   e-163
 gi|29349251|ref|NP_812754.1|  ATP-dependent protease ATP-bin...   578   e-163
 gi|53715361|ref|YP_101353.1|  ATP-dependent protease ATP-bin...   573   e-162
 gi|154494363|ref|ZP_02033683.1|  hypothetical protein PARMER...   567   e-160
 gi|150003036|ref|YP_001297780.1|  ATP-dependent Clp protease...   567   e-160
 gi|86130753|ref|ZP_01049352.1|  ATP-dependent protease ATP-b...   520   e-145


InterPro Summary:  InterProScan

InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [110-271]T 1.7000000000001E-11 SM00382 AAA AAA
InterPro
IPR004487
Family
ClpX, ATPase regulatory subunit
PTHR11262:SF4 [4-399]T 0.0 PTHR11262:SF4 ClpX ClpX
TIGR00382 [1-408]T 0.0 TIGR00382 clpX clpX
InterPro
IPR010603
Domain
Zinc finger, C4-type
PF06689 [7-46]T 2.9000003626990998E-5 PF06689 zf-C4_ClpX zf-C4_ClpX
InterPro
IPR013093
Domain
ATPase AAA-2
PF07724 [109-307]T 4.60000044330908E-75 PF07724 AAA_2 AAA_2
noIPR
unintegrated
unintegrated
G3DSA:1.10.8.60 [312-403]T 2.9000035467795797E-25 G3DSA:1.10.8.60 G3DSA:1.10.8.60 G3DSA:1.10.8.60
G3DSA:3.40.50.300 [55-311]T 1.3000049540732399E-92 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR11262 [4-399]T 0.0 PTHR11262 PTHR11262 PTHR11262
SSF52540 [59-403]T 3.8999999999999995E-70 SSF52540 SSF52540 SSF52540
SSF57716 [7-44]T 5.6E-10 SSF57716 SSF57716 SSF57716


COGS Summary:  COGS Search
BeTs to 12 clades of COG1219
COG name: ATP-dependent protease Clp, ATPase subunit ClpX
Functional Class: O
The phylogenetic pattern of COG1219 is ----yqvcebrhuj--olinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001939 (AAA-protein (ATPases associated with various cellular activities)) with a combined E-value of 3.8e-16.
    IPB001939A    74-94
    IPB001939B    111-132
    IPB001939C    159-192


 ProDom Summary:  Protein Domain Search
Residues 156-250 are 43% similar to a (HEAT SHOCK HSLU PROTEIN CHAPERONE ATP-BINDING INDUCED) protein domain (PD003010 which is seen in Q9ZDK8_RICPR.

Residues 64-380 are 58% similar to a (PROTEIN ATP-BINDING PROTEASE SUBUNIT REGULATORY HOMOLOG) protein domain (PD000092 which is seen in CLPX_BACSU.


Paralogs:  Local Blast Search
Residues 75-190 show 34% similarity to PG0041 putative ATPase/cell division protein.

Pfam Summary:  Pfam Search
Residues 10 to 46 (E-value = 2.4e-08) place PG0382 in the zf-C4_ClpX family which is described as ClpX C4-type zinc finger (PF06689)
Residues 113 to 319 (E-value = 2.8e-27) place PG0382 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-74% similar to PDB:1UM8 Crystal structure of helicobacter pylori ClpX (E_value = 3.0E_100);
-53% similar to PDB:1OFH ASYMMETRIC COMPLEX BETWEEN HSLV AND I-DOMAIN DELETED HSLU (H. INFLUENZAE) (E_value = 1.0E_47);
-53% similar to PDB:1OFI ASYMMETRIC COMPLEX BETWEEN HSLV AND I-DOMAIN DELETED HSLU (H. INFLUENZAE) (E_value = 1.0E_47);
-48% similar to PDB:1G3I CRYSTAL STRUCTURE OF THE HSLUV PROTEASE-CHAPERONE COMPLEX (E_value = 1.9E_22);
-48% similar to PDB:1G41 CRYSTAL STRUCTURE OF HSLU HAEMOPHILUS INFLUENZAE (E_value = 1.9E_22);

Gene Protein Sequence:
MAKKKDEEYCSFCGMPRTQVNLMLEGVHAHICDECALRAGEVVREALQKF
KSEETNNLKREDLPRPIEIKEFLDSYVIGQDDAKRFLSVAVYNHYKRLLQ
QEDSDGVEIEKSNIIMVGPTGTGKTLLARTIAKMLHVPFAVVDATVLTEA
GYVGEDIESILTRLLQAADYDVKQAERGIVFIDEIDKIARKSDNPSITRD
VSGEGVQQGLLKLLEGSIVNVPPQGGRKHPEQKMIPVDTRHILFVCAGAF
DGIEKKIAQRLNTRVVGYTAGLQNRHIDRENMLRYIRPQDLKSFGLIPEI
IGRLPILTHLEPLDRDALRNIMTEPKNAITKQYEKLFAMDGIKVSFTSDM
LDFVVDKAIEFKLGARGLRSIVETIMMDAMFTMPSGKKKTLVVDKAYAEA
HLNIDDLLQDQ

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCAAAGAAAAAGGACGAAGAATACTGTAGTTTTTGTGGCATGCCGAG
AACGCAGGTAAACCTGATGCTCGAAGGAGTCCATGCTCATATCTGCGATG
AATGTGCTCTCCGTGCAGGAGAGGTGGTTCGAGAAGCATTGCAAAAATTC
AAATCGGAAGAGACGAACAATCTGAAGAGAGAGGACTTGCCTCGGCCTAT
AGAGATCAAGGAATTTCTCGATTCGTATGTTATCGGGCAGGATGATGCCA
AACGTTTTCTTTCTGTCGCTGTATACAATCATTACAAACGATTGCTCCAG
CAAGAGGACAGCGATGGCGTAGAGATCGAGAAAAGCAATATTATTATGGT
CGGTCCCACGGGAACCGGCAAGACACTCTTGGCTCGTACGATAGCCAAAA
TGCTCCATGTTCCTTTCGCCGTAGTCGACGCTACGGTACTGACCGAAGCC
GGCTATGTGGGGGAAGACATTGAGAGTATTCTCACCAGACTTTTGCAGGC
CGCAGACTACGATGTCAAACAGGCCGAGAGAGGGATTGTCTTTATCGATG
AGATAGACAAGATAGCCCGTAAGAGTGATAATCCTTCGATTACGCGTGAT
GTCAGTGGCGAAGGAGTACAGCAAGGTTTGCTCAAACTTCTGGAAGGTTC
TATCGTAAATGTTCCTCCTCAAGGCGGTCGCAAACATCCGGAGCAGAAGA
TGATTCCGGTGGACACGAGGCATATTCTCTTCGTTTGTGCCGGAGCTTTC
GACGGCATAGAGAAGAAAATTGCTCAGCGACTCAATACTCGTGTTGTGGG
TTATACTGCCGGATTGCAAAACAGGCATATCGATCGTGAGAATATGCTTC
GCTATATTCGTCCGCAGGATTTGAAATCTTTTGGGCTGATTCCTGAAATC
ATCGGTCGTTTGCCTATTTTGACCCATTTGGAGCCGTTAGATCGGGATGC
CCTTAGAAACATCATGACGGAGCCCAAGAATGCCATTACCAAGCAATACG
AAAAACTGTTTGCCATGGATGGCATCAAGGTTTCTTTTACATCCGATATG
CTTGATTTCGTCGTTGATAAAGCTATCGAATTCAAACTGGGTGCACGCGG
ACTACGCTCCATCGTAGAGACGATCATGATGGATGCGATGTTCACGATGC
CATCAGGTAAGAAGAAGACTTTGGTCGTAGACAAAGCTTATGCAGAAGCT
CATTTGAATATTGACGATTTGCTACAAGATCAA

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