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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0321 IGR0319 IGR0325 IGR0320 IGR0326 IGR0323 IGR0324 IGR0322 PG0387 clpP, - PG0384 PG0390 PG0386 PG0385 clpX, - PG0382 PG0380 recQ, - PG0381 PG0389 PG0387 clpP, - PG0384 PG0390 PG0386 PG0385 clpX, - PG0382 PG0380 recQ, - PG0381 PG0389 PG0387 clpP, - PG0384 PG0390 PG0386 PG0385 clpX, - PG0382 PG0380 recQ, - PG0381 PG0389 PG0388 PG0388


LANL Gene ID: PG0384

GenBank Locus Tag: PG0418

DNA Molecule Name:
1  

GenBank ID:
34540241

Gene Name:
clpP  

Definition:
ATP-dependent clp protease proteolytic subunit (endopeptidase CLP)

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
459419

Gene Stop:
458754

Gene Length:
666

Molecular Weight*:
24790

pI*:
5.70

Net Charge*:
-3.13

EC:
3.4.21.92  

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0006508    proteolysis

Molecular function
  GO:0008462    endopeptidase Clp activity


Pathway: pathway table

Comment:
The ATP-binding subunit of the CLP protease is PG0009.

TIGR ID: PG0418

Proteomic Data: Proteomic Data Search
TIGR AnnotationATP-dependent Clp protease, proteolytic subunit, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0418-0.580.023-0.490.049-0.460.031-0.490.049
LANLPG03840.670.710.730.50
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits to ATP-dependent Clp protease, proteolytic subunit proteins in gapped BLAST; e.g. residues 24-217 are 58% similar to gb|AAD35777.1|AE001741_10 ATP-dependent Clp protease, proteolytic subunit of Thermotoga maritima, residues 32-216 are 61% similar to gb|AAD31002.1|AF127082_1 ATP-dependent protease proteolytic subunit ClpP of Myxococcus xanthus, residues 32-221 are 59% similar to dbj|BAB07283.1| ATP-dependent Clp protease proteolytic subunit of Bacillus halodurans.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540241|ref|NP_904720.1|  ATP-dependent Clp protease, pr...   439   e-122
 gi|154494362|ref|ZP_02033682.1|  hypothetical protein PARMER...   375   e-102
 gi|150009000|ref|YP_001303743.1|  ATP-dependent Clp protease...   364   2e-99
 gi|53715362|ref|YP_101354.1|  ATP-dependent Clp protease pro...   341   2e-92
 gi|156859571|gb|EDO53002.1|  hypothetical protein BACUNI_030...   333   3e-90
 gi|29349250|ref|NP_812753.1|  ATP-dependent Clp protease pro...   333   4e-90
 gi|153809070|ref|ZP_01961738.1|  hypothetical protein BACCAC...   333   4e-90
 gi|150003037|ref|YP_001297781.1|  ATP-dependent Clp protease...   323   5e-87
 gi|60683331|ref|YP_213475.1|  putative ATP-dependent CLP pro...   320   4e-86
 gi|88801527|ref|ZP_01117055.1|  ATP-dependent Clp protease p...   305   1e-81


InterPro Summary:  InterProScan

InterPro
IPR001907
Family
Peptidase S14, ClpP
PR00127 [46-61]T 2.6000000000000003E-49 PR00127 CLPPROTEASEP[86-106]T 2.6000000000000003E-49 PR00127 CLPPROTEASEP[117-134]T 2.6000000000000003E-49 PR00127 CLPPROTEASEP[138-157]T 2.6000000000000003E-49 PR00127 CLPPROTEASEP[195-214]T 2.6000000000000003E-49 PR00127 CLPPROTEASEP CLPPROTEASEP
PTHR10381 [83-221]T 1.59998835313659E-80 PTHR10381 Pept_S14_ClpP Pept_S14_ClpP
PF00574 [41-220]T 3.3000197611715704E-112 PF00574 CLP_protease CLP_protease
PS00382 [139-152]T 8.0E-5 PS00382 CLP_PROTEASE_HIS CLP_PROTEASE_HIS
noIPR
unintegrated
unintegrated
G3DSA:3.90.226.10 [29-221]T 6.199960405811581E-74 G3DSA:3.90.226.10 G3DSA:3.90.226.10 G3DSA:3.90.226.10
SSF52096 [39-221]T 2.6E-56 SSF52096 SSF52096 SSF52096


COGS Summary:  COGS Search
BeTs to 11 clades of COG0740
COG name: Protease subunits of ATP-dependent proteases, ClpP family
Functional Class: O
The phylogenetic pattern of COG0740 is -----qvCebRhuj--OLINx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001907 (Clp protease) with a combined E-value of 9.1e-80.
    IPB001907A    46-85
    IPB001907B    116-155
    IPB001907C    173-216


 ProDom Summary:  Protein Domain Search
Residues 32-218 are 57% similar to a (PROTEASE CLP HYDROLASE ENDOPEPTIDASE SERINE) protein domain (PD001650 which is seen in CLPP_AQUAE.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
Residues 41 to 220 (E-value = 2.7e-115) place PG0384 in the CLP_protease family which is described as Clp protease (PF00574)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
118  
134

Top PDB Hits:
-79% similar to PDB:1YG8 The structure of a V6A variant of ClpP. (E_value = 7.2E_59);
-78% similar to PDB:1TYF THE STRUCTURE OF CLPP AT 2.3 ANGSTROM RESOLUTION SUGGESTS A MODEL FOR ATP-DEPENDENT PROTEOLYSIS (E_value = 1.6E_58);
-78% similar to PDB:1YG6 ClpP (E_value = 1.6E_58);
-78% similar to PDB:2FZS Crystal structure of E. coli ClpP with a Peptide Chloromethyl Ketone Covalently Bound at the Active Site (E_value = 1.6E_58);
-75% similar to PDB:2C8T THE 3.0 A RESOLUTION STRUCTURE OF CASEINOLYTIC CLP PROTEASE 1 FROM MYCOBACTERIUM TUBERCULOSIS (E_value = 1.0E_52);

Gene Protein Sequence:
MNEFKKYATRHIGLNAQALDDYTRIQSSYISPTIIEERQLNVAQMDVFSR
LMMDRIIFLGTQIDDYTANVIQAQLLYLDSADPGKDISIYLNSPGGSVYA
GYGIYDTMQYIGCDVATICTGMAASMASVLLVAGTKGKRFALPHSRVMIH
QPLGGMQGQASDLEIAAREILRVKKELYTIISSHSGKPVEQVEKDSDRDY
WMTAPEALEYGMIDKILEKNRK

Gene Nucleotide Sequence:  Sequence Viewer
ATGAACGAATTCAAAAAATACGCGACCCGACATATCGGGTTGAATGCACA
GGCCTTGGACGACTATACCAGAATCCAAAGCAGCTACATCTCTCCGACCA
TTATCGAAGAACGCCAGTTGAACGTTGCACAAATGGATGTGTTCTCACGT
CTAATGATGGATCGGATCATCTTCCTTGGCACTCAGATCGACGATTACAC
GGCCAATGTCATTCAAGCACAGCTTCTTTATCTTGATAGCGCCGACCCCG
GTAAAGATATTTCCATCTATCTGAATTCACCCGGCGGATCTGTTTATGCC
GGTTATGGCATATACGATACGATGCAGTATATAGGGTGCGATGTGGCCAC
TATCTGTACGGGCATGGCTGCGTCTATGGCATCAGTGCTGCTCGTAGCAG
GAACGAAAGGCAAACGCTTTGCTTTGCCTCATTCCCGCGTGATGATACAT
CAGCCGCTTGGTGGTATGCAGGGGCAGGCCAGCGATTTGGAGATCGCAGC
TCGCGAGATTCTGCGCGTCAAGAAAGAGCTTTACACGATTATCTCTTCTC
ACAGTGGAAAGCCCGTCGAGCAGGTCGAAAAAGATAGTGATCGGGACTAT
TGGATGACAGCCCCCGAAGCATTGGAGTACGGGATGATAGATAAAATCCT
CGAAAAGAATCGAAAG

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