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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0343 IGR0341 IGR0344 IGR0342 IGR0339 IGR0340 PG0404.2 PG0408 PG0412 PG0405 pepT, - PG0407 PG0410 PG0411 PG0406 PG0404 PG0404.2 PG0408 PG0412 PG0405 pepT, - PG0407 PG0410 PG0411 PG0406 PG0404 Type: tandem, Name: tan60 - 268 PG0404.1 PG0404.2 PG0404.1 PG0408 PG0405 pepT, - PG0407 PG0410 PG0411 PG0406 PG0404 PG0409 PG0409 PG0412


LANL Gene ID: PG0407

GenBank Locus Tag: PG0445

DNA Molecule Name:
1  

GenBank ID:
34540266

Gene Name:
pepT  

Definition:
aminotripeptidase/peptidase T

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
485393

Gene Stop:
486607

Gene Length:
1215

Molecular Weight*:
44855

pI*:
5.40

Net Charge*:
-13.63

EC:
3.4.11.4  

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0006508    proteolysis
  GO:0006518    peptide metabolic process

Cellular component
  GO:0005737    cytoplasm

Molecular function
  GO:0008237    metallopeptidase activity
  GO:0008270    zinc ion binding
  GO:0016285    cytosol alanyl aminopeptidase activity
  GO:0016787    hydrolase activity
  GO:0045148    tripeptide aminopeptidase activity
  GO:0046983    protein dimerization activity


Pathway: pathway table
Glutathione metabolism

Comment:
TIGR ID: PG0445

Proteomic Data: Proteomic Data Search
TIGR Annotationpeptidase T, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0445-0.270.061-1.150.00032-0.814.9e-09-1.150.00032
LANLPG04070.830.450.570.53
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Residues 2 to 400 share 58% identity with pirH69674, an aminotripeptidase (EC 3.4.11.-) in Bacillus subtilis.
Residues 2 to 405 share 50% identity with gbAAG55931.1AE005327_1 (AE005327), an aminotripeptidase peptidase T (EC 3.4.11.-) in Escherichia coli.
Residues 2 to 405 share 51% identity with gbAAA27183.1 (M62725), the peptidase T in Salmonella typhimurium.

This sequence is similar to BT4583.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540266|ref|NP_904745.1|  peptidase T [Porphyromonas gin...   830   0.0  
 gi|20808225|ref|NP_623396.1|  peptidase T [Thermoanaerobacte...   494   e-138
 gi|118445113|ref|YP_879183.1|  peptidase T [Clostridium novy...   490   e-137
 gi|114845238|ref|ZP_01455655.1|  peptidase T [Thermoanaeroba...   486   e-136
 gi|76796577|ref|ZP_00778936.1|  Peptidase M20B , tripeptide ...   486   e-136
 gi|106893890|ref|ZP_01361013.1|  Peptidase M20B, tripeptide ...   485   e-135
 gi|29349991|ref|NP_813494.1|  peptidase T [Bacteroides theta...   481   e-134
 gi|153807753|ref|ZP_01960421.1|  hypothetical protein BACCAC...   478   e-133
 gi|156107769|gb|EDO09514.1|  hypothetical protein BACOVA_053...   478   e-133
 gi|138895315|ref|YP_001125768.1|  Peptidase T (tripeptidase)...   477   e-133


InterPro Summary:  InterProScan

InterPro
IPR001261
Family
ArgE/dapE/ACY1/CPG2/yscS
PS00758 [73-82]T 8.0E-5 PS00758 ARGE_DAPE_CPG2_1 ARGE_DAPE_CPG2_1
PS00759 [137-176]T 8.0E-5 PS00759 ARGE_DAPE_CPG2_2 ARGE_DAPE_CPG2_2
InterPro
IPR002933
Family
Peptidase M20
PF01546 [138-402]T 1.59999889349247E-11 PF01546 Peptidase_M20 Peptidase_M20
InterPro
IPR010161
Family
Peptidase M20B, tripeptide aminopeptidase
TIGR01882 [2-405]T 0.0 TIGR01882 peptidase-T peptidase-T
InterPro
IPR011650
Domain
Peptidase M20, dimerisation
PF07687 [205-309]T 9.50001028167257E-22 PF07687 M20_dimer M20_dimer
noIPR
unintegrated
unintegrated
G3DSA:3.40.630.10 [2-405]T 3.49999466863949E-97 G3DSA:3.40.630.10 G3DSA:3.40.630.10 G3DSA:3.40.630.10
PTHR11014 [1-91]T 4.50001022903281E-123 PTHR11014 PTHR11014[116-405]T 4.50001022903281E-123 PTHR11014 PTHR11014 PTHR11014
PTHR11014:SF3 [1-91]T 4.50001022903281E-123 PTHR11014:SF3 PTHR11014:SF3[116-405]T 4.50001022903281E-123 PTHR11014:SF3 PTHR11014:SF3 PTHR11014:SF3
SSF53187 [2-405]T 3.4E-76 SSF53187 SSF53187 SSF53187
SSF55031 [208-319]T 9.3E-41 SSF55031 SSF55031 SSF55031


COGS Summary:  COGS Search
No hit to the COGs database.
Blocks Summary:  Blocks Search
***** IPB001261 (ArgE/dapE/ACY1/CPG2/yscS family) with a combined E-value of 7.2e-24.
    IPB001261A    127-133
    IPB001261B    139-154
    IPB001261C    165-174
    IPB001261D    364-380


 ProDom Summary:  Protein Domain Search
Residues 214-400 are 54% similar to a (HYDROLASE PROTEIN ACID AMIDOHYDROLASE DESUCCINYLASE) protein domain (PD001757 which is seen in PEPT_BACSU.

Residues 2-212 are 53% similar to a (PEPTIDASE T AMINOTRIPEPTIDASE) protein domain (PD014167 which is seen in PEPT_BACSU.


Paralogs:  Local Blast Search
PG0407 is similar to two predicted aminoacyl-histidine dipeptidases, PG0123 and PG0489. Residues 42-176 share 34% identity with PG0123 and residues 29-203 share 28% identity with PG0489.

Pfam Summary:  Pfam Search
Residues 7 to 403 (E-value = 6e-53) place PG0407 in the Peptidase_M20 family which is described as Peptidase family M20/M25/M40 (PF01546)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-64% similar to PDB:1FNO PEPTIDASE T (TRIPEPTIDASE) (E_value = 1.1E_102);
-63% similar to PDB:1VIX Crystal structure of a putative peptidase T (E_value = 7.8E_101);

Gene Protein Sequence:
MELKERFLRYVGFDTQSDESSTTFPSTDKQLVLLRHLAKEMKDLGLCEVE
MDEHGYVMGSIPASPGCEHAPVIGFIAHVDTAPDMSGKDVKPQIIKNYNG
GDIRLNEELTMRVADFPELAFFKGHTLITTDGTTLLGADDKAGVAEIMTA
AEYLLAHPEVKHGKIRLGFTPDEEIGRGVDHFDVERFGAKFAYTMDGSME
GELEYENFNAASAKLTVNGRNIHPGYAKGKMVNSLQVVCDLHALLPEAMR
PEATAGYEGFFHLIGINGSVEKASASYIIRDHDRKLFEEKKELIKAAVDY
INRKYGSDIVSLELKDQYYNMREMVEPHPEIIEKAIAAMKLAGITAKVQP
IRGGTDGARLSYMGLPCPNIFAGGMNFHGKFEYCSLDSMRRAVDTICHLA
ALWAE

Gene Nucleotide Sequence:  Sequence Viewer
ATGGAACTGAAAGAGAGATTTCTCCGATATGTAGGCTTCGATACGCAAAG
CGACGAATCCTCTACCACTTTCCCCTCGACGGACAAGCAATTGGTGCTGC
TGCGTCATTTGGCCAAAGAGATGAAGGACCTCGGCCTGTGCGAGGTCGAA
ATGGACGAGCACGGCTATGTCATGGGCAGCATCCCTGCCTCTCCCGGTTG
TGAGCATGCGCCCGTGATCGGATTCATTGCGCATGTGGATACGGCCCCCG
ACATGAGCGGCAAGGACGTGAAGCCGCAAATCATCAAAAACTATAATGGC
GGCGATATTCGTCTGAACGAGGAACTGACTATGCGTGTAGCGGATTTCCC
CGAGTTGGCGTTCTTCAAAGGGCATACGCTGATCACTACGGACGGTACCA
CTCTGCTCGGTGCCGATGACAAAGCCGGTGTGGCCGAAATCATGACGGCT
GCCGAGTATCTGCTCGCACATCCCGAAGTCAAGCATGGCAAGATTCGCCT
CGGATTTACTCCCGACGAGGAAATCGGTCGGGGAGTGGATCACTTCGATG
TCGAGCGGTTCGGTGCCAAGTTCGCTTACACGATGGACGGCAGTATGGAA
GGAGAGTTGGAGTATGAGAACTTCAATGCGGCTTCGGCCAAACTGACCGT
AAACGGACGCAATATCCACCCCGGCTATGCCAAGGGAAAGATGGTCAATT
CGCTGCAGGTAGTGTGCGATCTGCATGCTCTTCTGCCCGAGGCTATGCGG
CCGGAGGCTACTGCCGGCTACGAAGGATTTTTCCACCTTATCGGCATCAA
CGGTTCGGTAGAGAAAGCATCGGCATCTTATATCATCCGCGATCACGACC
GCAAACTCTTTGAAGAGAAGAAAGAGCTGATCAAAGCTGCCGTAGACTAC
ATCAACCGCAAGTACGGCTCGGACATCGTGTCGCTCGAACTCAAAGATCA
GTATTACAATATGCGAGAGATGGTAGAGCCTCATCCCGAGATTATCGAAA
AAGCCATTGCTGCCATGAAGCTTGCCGGCATAACGGCCAAGGTGCAGCCT
ATTCGCGGCGGTACGGACGGGGCCAGACTCTCTTATATGGGACTCCCGTG
CCCGAATATATTTGCCGGTGGGATGAACTTCCACGGCAAGTTCGAATACT
GTTCGCTCGACTCCATGCGGCGGGCTGTGGACACGATCTGCCATTTGGCT
GCTCTTTGGGCTGAA

Los Alamos National Laboratory • Est 1943

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