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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0425 IGR0420 IGR0421 IGR0423 IGR0422 IGR0424 PG0500 PG0502 ISPg1, - PG0499 lysC, - PG0501 PG0504 PG0503 nifJ,pfo, - PG0498 PG0500 PG0502 ISPg1, - PG0499 lysC, - PG0501 PG0504 PG0503 nifJ,pfo, - PG0498 Type: tandem, Name: tan63 - 271 Type: IS element, Name: ISPg1 - 2 Type: tandem, Name: tan61 - 269 Type: tandem, Name: tan62 - 270 PG0500 PG0502 ISPg1, - PG0499 lysC, - PG0501 PG0504 PG0503 nifJ,pfo, - PG0498


LANL Gene ID: PG0501

GenBank Locus Tag: PG0553

DNA Molecule Name:
1  

GenBank ID:
34540364

Gene Name:
lysC  

Definition:
lysyl endopeptidase precursor (protease I precursor) (API)

Cellular Location:
Extracellular, Outer membrane [Evidence]

Gene Start:
611280

Gene Stop:
608461

Gene Length:
2820

Molecular Weight*:
102500

pI*:
6.40

Net Charge*:
-6.13

EC:
3.4.21.50  

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0006508    proteolysis
  GO:0015986    ATP synthesis coupled proton transport

Cellular component
  GO:0016469    proton-transporting two-sector ATPase complex

Molecular function
  GO:0004252    serine-type endopeptidase activity
  GO:0005524    ATP binding
  GO:0046933    hydrogen ion transporting ATP synthase activity, rotational mechanism
  GO:0046961    hydrogen ion transporting ATPase activity, rotational mechanism


Pathway: pathway table

Secondary Evidence:
Ohara,T., Makino,K., Shinagawa,H., Nakata,A., Norioka,S. and
Sakiyama,F. 1989. Cloning, nucleotide sequence, and expression of Achromobacter protease I gene. J. Biol. Chem. 264 (34): 20625-20631. PubMed: 2684982.

Comment:
TIGR ID: PG0553

Proteomic Data: Proteomic Data Search
TIGR Annotationextracellular protease, putative, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0553-0.472e-08-0.520.00590.190.0077-0.520.0059
LANLPG05010.720.701.140.80
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Few significant hits in gapped BLAST to lysyl endopeptidase protein; i.e. residues 1-4706 are 25% similar to [77548] lysyl endopeptidase precursor of Achromobacter lyticus (strain M497-1), residues 208-449 are 31% similar to (AF083621) endoproteinase Arg-C precursor of Lysobacter enzymogenes and residues 218-486 are 26% similar to [7463016] lysyl endopeptidase of Lysobacter enzymogenes.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540364|ref|NP_904843.1|  extracellular protease, putati...  1873   0.0  
 gi|154493339|ref|ZP_02032659.1|  hypothetical protein PARMER...   333   4e-89
 gi|150009421|ref|YP_001304164.1|  extracellular protease, pu...   318   1e-84
 gi|113941922|ref|ZP_01427695.1|  Lysyl endopeptidase [Herpet...   182   9e-44
 gi|91217443|ref|ZP_01254402.1|  lysyl endopeptidase precurso...   180   3e-43
 gi|89890088|ref|ZP_01201599.1|  putative lysyl endopeptidase...   166   7e-39
 gi|154494430|ref|ZP_02033750.1|  hypothetical protein PARMER...   149   9e-34
 gi|149370928|ref|ZP_01890523.1|  lysyl endopeptidase precurs...   143   5e-32
 gi|154490375|ref|ZP_02030636.1|  hypothetical protein PARMER...   139   7e-31
 gi|118072355|ref|ZP_01540545.1|  peptidase-like [Shewanella ...   130   3e-28


InterPro Summary:  InterProScan

InterPro
IPR000194
Domain
ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding
PS00152 [381-390]? 0.0 PS00152 ATPASE_ALPHA_BETA ATPASE_ALPHA_BETA
InterPro
IPR001254
Domain
Peptidase S1 and S6, chymotrypsin/Hap
PS00134 [268-273]? 0.0 PS00134 TRYPSIN_HIS TRYPSIN_HIS
InterPro
IPR009003
Domain
Peptidase, trypsin-like serine and cysteine
SSF50494 [213-479]T 4.899999999999999E-35 SSF50494 Pept_Ser_Cys Pept_Ser_Cys
noIPR
unintegrated
unintegrated
G3DSA:2.40.10.10 [327-445]T 1.10000029896149E-6 G3DSA:2.40.10.10 G3DSA:2.40.10.10 G3DSA:2.40.10.10


COGS Summary:  COGS Search
No hit to the COGs database.
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 74-392 are 23% similar to a (PRECURSOR SIGNAL PROTEASE I) protein domain (PD141337 which is seen in API_ACHLY.


Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
No significant hits to the Pfam 11.0 database

 Structural Feature(s):
Feature Type  Start  Stop
cleavable signal  
1  
20
gram negative signal  
1  
27
non-globular  
383  
458

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
MNKFYKSLLQSGLAAFVSMATALTASAQISFGGEPLSFSSRSAGTHSFDD
AMTIRLTPDFNPEDLIAQSRWQSQRDGRPVRIGQVIPVDVDFASKASHIS
SIGDVDVYRLQFKLEGAKAITLYYDAFNIPEGGRLYIYTPDHEIVLGAYT
NATHRRNGAFATEPVPGSELIMDYEVSRGGTLPDIKISGAGYIFDKVGGR
PVTDNHYGIGEDDSDSDCEININCPEGADWQAEKNGVVQMIMVKGQYISM
CSGNLLNNTKGDFTPLIISAGHCASITTNFGVTQSELDKWIFTFHYEKRG
CSNGTLAIFRGNSIIGASMKAFLPIKGKSDGLLLQLNDEVPLRYRVYYNG
WDSTPDIPSSGAGIHHPAGDAMKISILKKTPALNTWISSSGSGGTDDHFY
FKYDQGGTEGGSSGSSLFNQNKHVVGTLTGGAGNCGGTEFYGRLNSHWNE
YASDGNTSRMDIYLDPQNNGQTTILNGTYRDGYKPLPSVPRLLLQSTGDQ
VELNWTAVPADQYPSSYQVEYHIFRNGKEIATTKELSYSDAIDESIIGSG
IIRYEVSARFIYPSPLDGVESYKDTDKTSADLAIGDIQTKLKPDVTPLPG
GGVSLSWKVPFLSQLVSRFGESPNPVFKTFEVPYVSAAAAQTPNPPVGVV
IADKFMAGTYPEKAAIAAVYVMPSAPDSTFHLFLKSNTNRRLQKVTTPSD
WQAGTWLRINLDKPFPVNNDHMLFAGIRMPNKYKLNRAIRYVRNPDNLFS
ITGKKISYNNGVSFEGYGIPSLLGYMAIKYLVVNTDAPKIDMSLVQEPYA
KGTNVAPFPELVGIYVYKNGTFIGTQDPSVTTYSVSDGTESDEYEIKLVY
KGSGISNGVAQIENNNAVVAYPSVVTDRFSIKNAHMVHAAALYSLDGKQV
RSWNNLRNGVTFSVQGLTAGTYMLVMQTANGPVSQKIVKQ

Gene Nucleotide Sequence:  Sequence Viewer
ATGAACAAATTTTACAAATCACTTTTGCAGTCAGGACTGGCTGCCTTCGT
GTCGATGGCAACTGCACTGACCGCTTCTGCACAGATTTCGTTCGGAGGGG
AACCCTTGAGTTTCTCTTCAAGATCCGCCGGAACGCATTCATTCGACGAT
GCAATGACTATCCGCCTTACTCCGGATTTCAATCCGGAAGACCTGATCGC
ACAGAGCCGTTGGCAATCGCAAAGAGATGGCCGGCCCGTCCGGATAGGAC
AAGTAATACCGGTGGATGTGGACTTTGCATCCAAGGCTTCGCACATCTCT
TCCATCGGAGACGTAGATGTATATCGCCTGCAATTCAAGTTGGAAGGAGC
CAAAGCCATTACGCTTTATTACGATGCATTCAATATTCCGGAGGGCGGAC
GCCTCTATATCTATACCCCCGACCATGAAATTGTGTTGGGAGCATATACG
AACGCCACTCATCGCCGCAACGGAGCTTTTGCCACAGAGCCGGTACCGGG
GAGTGAGCTTATTATGGATTATGAAGTGTCTCGCGGAGGGACTTTGCCTG
ACATCAAGATCTCCGGTGCGGGTTATATATTCGACAAAGTCGGCGGACGC
CCCGTAACGGATAACCATTACGGGATCGGTGAGGACGATTCCGATTCGGA
TTGCGAGATCAACATCAATTGTCCTGAAGGTGCAGACTGGCAGGCAGAGA
AGAACGGTGTGGTGCAAATGATCATGGTAAAAGGACAGTATATCTCAATG
TGCTCAGGCAACCTGCTCAATAATACGAAAGGAGACTTTACTCCGCTGAT
CATTTCTGCCGGACACTGTGCTTCCATAACAACCAATTTCGGTGTAACGC
AATCCGAGTTGGATAAGTGGATCTTCACTTTCCACTATGAAAAAAGAGGA
TGCAGCAATGGTACATTGGCCATCTTCCGTGGCAACAGTATCATCGGAGC
TTCCATGAAGGCTTTCCTCCCGATCAAAGGTAAATCCGATGGTCTCTTGC
TGCAACTCAACGATGAAGTCCCTCTGCGCTATCGTGTCTATTACAATGGA
TGGGACAGTACGCCCGATATTCCCTCGAGCGGTGCCGGTATTCATCATCC
GGCCGGAGATGCCATGAAGATTTCCATCCTAAAGAAGACTCCGGCTCTGA
ATACATGGATCTCCTCCAGTGGTTCCGGAGGGACTGACGATCACTTCTAT
TTCAAATACGATCAAGGTGGTACGGAAGGAGGATCGTCCGGTTCTTCTCT
CTTCAATCAGAATAAGCACGTGGTCGGCACACTGACCGGAGGTGCCGGCA
ATTGTGGCGGGACGGAGTTCTACGGCAGACTGAACAGTCATTGGAACGAG
TATGCATCCGATGGCAATACGAGCCGCATGGACATCTATCTGGATCCCCA
AAACAATGGCCAGACGACCATCCTCAACGGAACGTATCGTGACGGTTATA
AGCCTTTGCCCTCTGTGCCCCGGCTATTGTTGCAGTCTACAGGCGATCAG
GTCGAATTGAATTGGACGGCTGTTCCTGCCGATCAATATCCATCATCTTA
TCAGGTCGAATACCACATATTCCGAAATGGAAAGGAAATAGCTACGACAA
AGGAGTTGTCCTATTCGGATGCCATCGACGAAAGTATTATCGGTAGCGGT
ATCATTCGATACGAAGTAAGCGCACGCTTCATTTATCCCTCGCCGTTGGA
TGGAGTGGAATCTTATAAGGATACGGACAAGACTTCTGCCGACCTTGCCA
TAGGAGACATTCAGACCAAGCTGAAGCCGGACGTAACACCTCTCCCCGGA
GGAGGAGTATCATTAAGCTGGAAAGTTCCTTTCTTAAGCCAGTTGGTTTC
CCGATTCGGAGAAAGCCCCAATCCTGTGTTCAAAACCTTTGAAGTGCCCT
ATGTTTCTGCCGCAGCCGCACAAACCCCCAATCCTCCCGTTGGCGTAGTC
ATTGCAGACAAGTTTATGGCCGGTACATATCCCGAAAAGGCTGCTATCGC
TGCCGTTTATGTAATGCCATCCGCTCCGGACTCTACTTTCCACCTCTTCC
TCAAGAGCAACACAAACAGAAGATTGCAGAAGGTGACAACTCCCTCCGAT
TGGCAGGCCGGAACATGGTTGAGGATCAATTTGGATAAGCCGTTCCCGGT
GAATAATGACCATATGCTTTTTGCCGGTATCAGAATGCCTAATAAGTACA
AGCTCAATCGTGCTATCCGTTATGTAAGAAATCCGGATAACCTTTTCTCC
ATTACCGGTAAGAAGATTTCATATAACAACGGAGTCTCTTTCGAAGGCTA
CGGAATACCCTCGCTCTTGGGCTATATGGCTATCAAATATCTGGTGGTAA
ATACCGATGCTCCGAAGATCGATATGTCGCTTGTACAGGAGCCTTATGCT
AAGGGAACGAATGTGGCTCCATTCCCCGAATTGGTCGGCATATATGTCTA
TAAGAACGGAACATTTATCGGCACACAGGATCCATCCGTCACAACTTATT
CGGTTTCAGACGGAACAGAGAGCGATGAATACGAAATAAAACTGGTATAT
AAGGGATCGGGCATTTCGAATGGCGTTGCTCAGATTGAGAATAACAATGC
TGTCGTTGCATATCCGTCTGTTGTAACAGATCGTTTCAGCATTAAGAACG
CTCATATGGTTCACGCTGCCGCCCTCTACTCATTGGATGGCAAGCAGGTT
CGTTCTTGGAACAACCTCCGCAATGGCGTGACATTCAGTGTTCAAGGACT
TACGGCCGGTACTTATATGCTCGTTATGCAGACGGCAAACGGCCCTGTGA
GCCAAAAGATCGTGAAGCAG

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