LANL Gene ID: PG0582
GenBank Locus Tag:
DNA Molecule Name:
1
GenBank ID:
Gene Name:
tla tlr
Definition:
tonB-linked receptor Tlr
Cellular Location:
Outer membrane, Cytoplasm [Evidence]
Gene Start:
697077
Gene Stop:
695722
Gene Length:
1356
Molecular Weight*:
50608
pI*:
10.10
Net Charge*:
21.22
EC:
Functional Class:
Uncategorized
Gene Ontology:
Biological process
GO:0006810 transport
Cellular component
GO:0016020 membrane
Molecular function
GO:0004872 receptor activity
GO:0005215 transporter activity
Pathway: pathway table
Primary Evidence:
Slakeski N, Dashper SG, Cook P, Poon C, Moore C, Reynolds EC.
A Porphyromonas gingivalis genetic locus encoding a heme transport system.
Oral Microbiol Immunol. 2000 Dec;15(6):388-92.
PMID: 11154437
Aduse-Opoku,J., Slaney,J.M., Rangarajan,M., Muir,J., Young,K.A. and Curtis,M.A., "The Tla protein of Porphyromonas gingivalis W50: a homolog of the RI protease precursor (PrpRI) is an outer membrane receptor required for growth on low levels of hemin", J. Bacteriol. 179 (15), 4778-4788 (1997).
M: 97386416.
Comment:
See PG0581: T1a is thought to be greater than 1000 amino acids.
T1a is virtually identical to the C-terminal half of PrtP (PG1605). See also PG1768, PG1602 and PG0461.
NO TIGR ID corresponds to this gene.
Human Oral Microbiome Database:
View in HOMD Genome Viewer
Blast Summary: PSI-Blast Search
This sequence corresponds in part (see PG0581) to the previously sequenced AF155223 in GenBANK, a predicted ton-B receptor T1r.
Top Blast Hits: Updated monthly
Click here to view the entire PsiBlast results.
InterPro Summary: InterProScan
| InterPro IPR012910 Domain 
|
| |||||||||||||
| noIPR unintegrated |
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![[86-188]T 1.3e-22 PF07715 Plug](http://www.ebi.ac.uk/InterProScan/images/H.gif){kind=small}
![[66-193]T 1.3e-26 G3DSA:2.170.130.10 no description](http://www.ebi.ac.uk/InterProScan/images/G.gif){kind=small}
![[43-58]? NA tmhmm transmembrane_regions](http://www.ebi.ac.uk/InterProScan/images/T.gif){kind=small}
COGS Summary: COGS Search
BeTs to 4 clades of COG1629
COG name: Outer membrane receptor proteins, mostly Fe transport
Functional Class: P
The phylogenetic pattern of COG1629 is -----q-CE--HUJ-------
Number of proteins in this genome belonging to this COG is 8
Blocks Summary: Blocks Search
No significant hit to the Blocks database.
ProDom Summary: Protein Domain Search
Residues 130-198 are identical to a (RECEPTOR PROTEIN OUTER MEMBRANE PRECURSOR SIGNAL TONB) protein domain (PD000492 which is seen in P72196_PORGI.
Residues 199-311 are identical to a (TONB-LINKED ADHESIN PRECURSOR SIGNAL) protein domain (PD125299 which is seen in P72196_PORGI.
Residues 6-129 are 99% similar to a (TONB-LINKED ADHESIN PRECURSOR SIGNAL) protein domain (PD078199 which is seen in P72196_PORGI.
Paralogs: Local Blast Search
Residues 37-205 are 31% similar to PG1358, residues 68-205 are 28% similar to PG0601, residues 72-389 are 20% similar to PG0637.
Pfam Summary: Pfam Search
No significant hits to the Pfam 11.0 database
Structural Feature(s):
| Feature Type | Start | Stop |
| transmembrane | ||
| transmembrane | ||
| coil-coil |
Top PDB Hits:
-55% similar to PDB:1NQE OUTER MEMBRANE COBALAMIN TRANSPORTER (BTUB) FROM E. COLI (E_value = 1.9E_10);
-55% similar to PDB:1NQF OUTER MEMBRANE COBALAMIN TRANSPORTER (BTUB) FROM E. COLI, METHIONINE SUBSTIUTION CONSTRUCT FOR SE-MET SAD PHASING (E_value = 1.9E_10);
-55% similar to PDB:1NQG OUTER MEMBRANE COBALAMIN TRANSPORTER (BTUB) FROM E. COLI, WITH BOUND CALCIUM (E_value = 1.9E_10);
-55% similar to PDB:1NQH OUTER MEMBRANE COBALAMIN TRANSPORTER (BTUB) FROM E. COLI, WITH BOUND CALCIUM AND CYANOCOBALAMIN (VITAMIN B12) SUBSTRATE (E_value = 1.9E_10);
-55% similar to PDB:1UJW Structure of the complex between BtuB and Colicin E3 Receptor binding domain (E_value = 1.9E_10);
Gene Protein Sequence:
LYADKMRRHIVKCCPSASILLQEYSTTELFIHHFNISIIMKKFFFALLSI
GISAQAFAKTDNVPTDSLRVHNLQTVTVYSTRTAVPLKKIPAKMELISSR
NIKQSGFNNMTDILKTQSSLDVIQYPGFSSNIGIRGFKPSGKYVTVLVNG
IPAGTDNISTLNTSNIEQIEILKGPFSSIYGTNAMGGVVNIITHKSKDKI
HGNVSLFGGSYQTMAGSFNLGGRFEDIFSFDLSLGLDKQNKDYKTGSNNF
LSLSKLEEAIVDVNATKNKKMKGSDYTVATGRLRFGIDFTPEWSLNLYQN
VFLGDAIPVGGSIWGVYGESKKNLNRSSTSFELLGKHGCHTLQFSPYFNI
EKSENYNNADPTGFINYKSDYYTYGALLQDKISFGGQKYRTRCRQPKHDD
GVRKIRAGRSEYKAIQPRICHEQYRFVRTGQFLPAERCSIDICRCTCRLH
VL
Gene Nucleotide Sequence: Sequence Viewer
TTGTATGCGGACAAGATGCGCCGGCATATCGTCAAGTGCTGTCCCTCTGC
CTCCATACTCTTGCAAGAATACTCCACAACAGAATTATTCATTCATCACT
TTAACATATCAATAATTATGAAAAAGTTTTTCTTCGCGCTACTATCGATT
GGTATTTCAGCGCAGGCTTTTGCCAAGACGGACAACGTCCCGACAGATTC
GCTACGAGTACACAATCTTCAGACCGTCACGGTCTATTCTACACGCACGG
CCGTACCTCTGAAAAAGATACCGGCCAAGATGGAACTCATCTCATCGCGC
AACATCAAGCAGTCCGGCTTTAACAACATGACCGACATCCTCAAGACGCA
AAGTTCGCTCGATGTCATACAATACCCGGGCTTTAGTTCGAACATCGGTA
TCCGCGGTTTCAAGCCCTCCGGCAAGTATGTAACCGTATTGGTAAACGGC
ATCCCTGCGGGAACGGACAATATCTCTACGCTCAACACGAGCAACATCGA
ACAAATCGAGATCCTCAAAGGCCCGTTCTCTTCCATCTACGGCACCAATG
CCATGGGCGGTGTGGTGAACATCATCACCCACAAATCCAAGGACAAGATC
CATGGCAACGTTTCTCTCTTCGGCGGTAGCTACCAGACCATGGCCGGATC
ATTCAACTTGGGTGGCCGCTTCGAGGATATTTTCTCATTCGATCTTAGTC
TGGGCTTGGACAAGCAGAACAAGGACTATAAGACCGGATCAAACAATTTC
CTATCCCTGAGCAAACTGGAAGAAGCTATAGTAGATGTAAATGCTACCAA
AAACAAGAAAATGAAGGGGAGCGACTATACTGTAGCAACGGGACGTCTGC
GTTTCGGTATCGACTTCACGCCCGAATGGTCGCTGAATCTGTATCAAAAC
GTATTCCTCGGAGATGCGATCCCCGTAGGAGGATCTATATGGGGCGTTTA
CGGAGAATCCAAAAAAAATCTGAATCGTTCTTCGACCTCTTTCGAGCTGC
TCGGCAAACATGGCTGCCACACGCTTCAATTCTCCCCCTACTTCAACATA
GAGAAATCGGAGAACTATAACAATGCCGATCCCACCGGTTTCATCAACTA
CAAAAGCGACTACTACACCTATGGTGCCCTACTCCAGGACAAGATTTCCT
TTGGAGGACAAAAATATCGTACTCGGTGTCGACAGCCGAAACATGACGAT
GGAGTCAGAAAGATTCGAGCAGGCAGGAGTGAATACAAAGCCATACAACC
CCGGATATGCCACGAACAATATCGGTTTGTTCGGACAGGCCAATTTCTAC
CTGCTGAACGATGCTCTATCGATATCTGCCGGTGCACGTGCCGACTTCAT
GTTCTT