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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0556 IGR0551 IGR0550 IGR0557 IGR0554 IGR0553 IGR0548 IGR0552 IGR0549 IGR0555 PG0651.2 PG0654 PG0648 arlR,resD, - PG0650 ddlA, - PG0656 rluD,sfhB, - PG0658 PG0655 PG0649 PG0651.1 PG0651 PG0653 dppIV, - PG0652 PG0651.2 PG0654 PG0648 arlR,resD, - PG0650 ddlA, - PG0656 rluD,sfhB, - PG0658 PG0655 PG0649 PG0651.1 PG0651 PG0653 dppIV, - PG0652 PG0651.2 PG0654 PG0648 arlR,resD, - PG0650 ddlA, - PG0656 rluD,sfhB, - PG0658 PG0655 PG0649 PG0651 PG0653 dppIV, - PG0652 PG0651.1


LANL Gene ID: PG0652

GenBank Locus Tag: PG0724

DNA Molecule Name:
1  

GenBank ID:
34540516

Gene Name:
dppIV  

Definition:
dipeptidyl peptidase IV

Cellular Location:
Periplasm, Cytoplasm, Extracellular [Evidence]

Gene Start:
775370

Gene Stop:
777313

Gene Length:
1944

Molecular Weight*:
73737

pI*:
6.10

Net Charge*:
-7.72

EC:
3.4.19.1  

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0006508    proteolysis

Molecular function
  GO:0008236    serine-type peptidase activity


Pathway: pathway table

Comment:
TIGR ID: PG0724

Proteomic Data: Proteomic Data Search
TIGR Annotationprolyl oligopeptidase family protein, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG0724-0.471.7e-05-0.800.000130.608e-09-0.800.00013
LANLPG06520.720.571.521.02
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Gapped BLAST shows numerous significant hits to prokaryotic and eukaryotic peptidases including alanyl dipeptidyl peptidase in Xylella fastidiosa (AAF85059), probable acylaminoacyl-peptidase in Aspergillus fumigatus (gb|AAB67282) and AAD52012 in Trichophyton rubrum.

This sequence is similar to BT0587.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540516|ref|NP_904995.1|  prolyl oligopeptidase family p...  1340   0.0  
 gi|156860071|gb|EDO53502.1|  hypothetical protein BACUNI_027...   822   0.0  
 gi|60682106|ref|YP_212250.1|  putative exported aminopeptida...   820   0.0  
 gi|53713897|ref|YP_099889.1|  putative peptidase [Bacteroide...   820   0.0  
 gi|154493660|ref|ZP_02032980.1|  hypothetical protein PARMER...   819   0.0  
 gi|150008116|ref|YP_001302859.1|  putative peptidase [Paraba...   815   0.0  
 gi|29345997|ref|NP_809500.1|  prolyl oligopeptidase family p...   809   0.0  
 gi|153806662|ref|ZP_01959330.1|  hypothetical protein BACCAC...   808   0.0  
 gi|156108504|gb|EDO10249.1|  hypothetical protein BACOVA_036...   803   0.0  
 gi|150005859|ref|YP_001300603.1|  prolyl oligopeptidase fami...   783   0.0


InterPro Summary:  InterProScan

InterPro
IPR001375
Domain
Peptidase S9, prolyl oligopeptidase active site region
PF00326 [435-648]T 6.70002630158945E-56 PF00326 Peptidase_S9 Peptidase_S9
InterPro
IPR011659
Repeat
WD40-like Beta Propeller
PF07676 [47-82]T 0.00360000038700736 PF07676 PD40[91-129]T 1799.9995165467599 PF07676 PD40[181-223]T 0.10999999970229601 PF07676 PD40[231-273]T 320.000074719642 PF07676 PD40 PD40
noIPR
unintegrated
unintegrated
G3DSA:2.120.10.30 [16-335]T 2.6999899778780296E-47 G3DSA:2.120.10.30 G3DSA:2.120.10.30 G3DSA:2.120.10.30
G3DSA:3.40.50.1820 [386-648]T 4.200034604930561E-75 G3DSA:3.40.50.1820 G3DSA:3.40.50.1820 G3DSA:3.40.50.1820
PTHR11731 [3-646]T 0.0 PTHR11731 PTHR11731 PTHR11731
PTHR11731:SF7 [3-646]T 0.0 PTHR11731:SF7 PTHR11731:SF7 PTHR11731:SF7
SSF53474 [386-647]T 1.1E-69 SSF53474 SSF53474 SSF53474
SSF82171 [2-386]T 3.2999999999999994E-48 SSF82171 SSF82171 SSF82171


COGS Summary:  COGS Search
BeTs to 4 clades of COG1506
COG name: Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
Functional Class: E
The phylogenetic pattern of COG1506 is ---KY--c-b-----------
Number of proteins in this genome belonging to this COG is 5
Blocks Summary:  Blocks Search
***** PF00930 (Dipeptidyl peptidase IV (DPP IV) N-terminal region) with a combined E-value of 1.2e-10.
    PF00930A    103-124
    PF00930B    215-265
    PF00930G    408-445
    PF00930H    445-487
    PF00930J    582-602
***** IPB002471 (Prolyl endopeptidase family serine active site) with a combined E-value of 7.8e-07.
    IPB002471A    65-77
    IPB002471B    481-511


 ProDom Summary:  Protein Domain Search
Residues 35-131 are 36% similar to a (POLYPROTEIN APICAL GUT MEMBRANE C31C9.1 PROTEIN) protein domain (PD043995 which is seen in Q25021_HAECO.

Residues 504-623 are 37% similar to a (DIPEPTIDYL HYDROLASE PROTEIN IV PEPTIDASE PROTEASE) protein domain (PD003048 which is seen in O13479_ASPFU.

Residues 304-501 are 30% similar to a (DIPEPTIDYL HYDROLASE IV PROTEIN PEPTIDASE PROTEASE) protein domain (PD001060 which is seen in O58593_PYRHO.

Residues 1-378 are 21% similar to a (SECRETED DIPEPTIDYL PEPTIDASE PRECURSOR) protein domain (PD141829 which is seen in O13479_ASPFU.

Residues 178-344 are 25% similar to a (PROTEIN TOLB PRECURSOR COLICIN) protein domain (PD025102 which is seen in TOLB_ECOLI.


Paralogs:  Local Blast Search
Residues 10-647 are 23% similar to PG1528, probable acylaminoacyl peptidase.
Residues 167-634 are 23% similar to PG1196 dipeptidyl peptidase IV.
Residues 5-648 are 20% similar to PG0897 probable acylamino-acid-releasing enzyme (dipeptidyl aminopeptidase).
Residues 298-623 are 23% similar to PG0459, dipeptidyl peptidase IV (DPP IV) N-terminal region.



Pfam Summary:  Pfam Search
Residues 39 to 434 (E-value = 4.9e-05) place PG0652 in the DPPIV_N family which is described as Dipeptidyl peptidase IV (DPP IV) N-terminal region (PF00930)

 Structural Feature(s):
Feature Type  Start  Stop
No predicted structural features.  
  

Top PDB Hits:
-38% similar to PDB:2D5L Crystal Structure of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis (E_value = 9.3E_17);
-38% similar to PDB:2DCM The Crystal Structure of S603A Mutated Prolyl Tripeptidyl Aminopeptidase Complexed with Substrate (E_value = 2.1E_16);
-41% similar to PDB:1Z68 Crystal Structure Of Human Fibroblast Activation Protein alpha (E_value = 8.1E_13);
-41% similar to PDB:1ORV Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) (E_value = 7.6E_11);
-41% similar to PDB:1ORW Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Peptidomimetic Inhibitor (E_value = 7.6E_11);

Gene Protein Sequence:
MTLSRVSEMALSPDGKTAVYAVSFPDVKTNKATRELFTVNLDGSGRKQIT
DTESNEYAPAWMADGKRIAFMSNEGGSMQLWVMNADGTERRQLSNIEGGI
TGFLFSPDEKQVLFTKDIKFGKRTKDIYPDLDKATGRIITDLMYKHWDEW
VETIPHPFIANATDGMITTGKDIMEGEPYEAPMKPWSGIEDFSWSPDGQN
IAYASRKKTGMAYSLSTNSDIYIYNLASGRTHNISEGMMGYDTYPKFSPD
GKSIAWISMERDGYESDLKRLFVADLATGKRTHVNPTFDYNVDMIQWAPD
SKGIYFLACKEAETNLWEITLKTGKIRQITQGQHDYADFSVRNDVMLAKR
HSFELPDDLYRVNLKNGAAQAVTAENKVILDRLTPITCEKRWMKTTDGGN
MLTWVVLPPNFDKNKKYPAILYCQGGPQNTVSQFWSFRWNLRLMAEQGYI
VIAPNRHGVPGFGQKWNEQISGDYGGQNMRDYLTAVDEMKKEPYVDGDRI
GAVGASYGGFSVYWLAGHHDKRFAAFIAHAGIFNLEMQYATTEEMWFANW
DIGGPFWEKDNVVAQRTYATSPHKFVQNWDTPILMIHGELDFRILASQAM
AAFDAAQLRGVPSEMLIYPDENHWVLQPQNALLFHRTFFGWLDRWLKK

Gene Nucleotide Sequence:  Sequence Viewer
ATGACCCTGTCGCGGGTGAGCGAAATGGCCTTGTCTCCCGACGGTAAAAC
GGCTGTTTATGCCGTCAGCTTTCCCGATGTCAAAACGAACAAGGCTACCC
GCGAGCTATTTACCGTCAATCTCGATGGTTCGGGGCGTAAGCAGATAACC
GACACCGAGTCCAACGAATACGCTCCTGCCTGGATGGCCGACGGTAAGCG
CATTGCTTTTATGAGCAACGAAGGCGGCAGCATGCAGCTTTGGGTCATGA
ACGCCGATGGTACGGAACGCCGCCAACTCAGCAATATCGAAGGTGGTATT
ACAGGTTTTCTTTTCTCCCCGGACGAGAAACAGGTGCTTTTCACCAAAGA
CATCAAATTCGGCAAACGCACCAAAGACATTTATCCCGATTTGGACAAAG
CTACCGGACGCATCATCACCGATCTGATGTATAAGCATTGGGACGAGTGG
GTGGAGACCATACCGCATCCCTTCATCGCGAACGCGACGGATGGAATGAT
CACCACCGGCAAAGACATCATGGAGGGCGAACCCTACGAGGCTCCGATGA
AACCGTGGTCGGGTATCGAAGATTTCAGTTGGAGCCCTGACGGACAGAAC
ATAGCATACGCCAGCCGCAAGAAAACGGGCATGGCATATTCTCTGTCTAC
CAACTCGGACATATATATCTATAATCTGGCTTCCGGCCGGACGCACAACA
TTTCCGAAGGGATGATGGGCTACGACACCTATCCGAAGTTCAGCCCCGAC
GGCAAGAGCATTGCATGGATCAGCATGGAGCGCGATGGATATGAAAGCGA
TCTGAAGCGTCTTTTCGTGGCGGATCTTGCCACAGGAAAACGCACCCATG
TAAACCCCACATTCGATTACAATGTGGATATGATCCAATGGGCACCGGAC
AGTAAGGGTATCTATTTCCTTGCCTGTAAGGAGGCAGAGACCAATCTGTG
GGAGATCACGCTGAAAACGGGTAAGATCCGTCAGATCACGCAAGGACAGC
ACGACTATGCCGACTTCTCCGTGCGCAACGACGTTATGCTGGCCAAACGC
CATTCTTTCGAACTCCCCGACGATCTCTATCGTGTGAATCTGAAGAATGG
AGCGGCACAGGCTGTCACGGCAGAAAACAAAGTCATCCTCGATCGTCTCA
CTCCCATCACCTGCGAAAAACGCTGGATGAAGACTACCGATGGAGGCAAT
ATGCTTACATGGGTAGTACTGCCACCCAACTTCGATAAAAACAAGAAATA
TCCGGCTATACTCTATTGTCAGGGAGGTCCGCAGAATACCGTAAGCCAGT
TCTGGTCGTTCCGCTGGAATCTCCGACTGATGGCCGAGCAGGGCTATATC
GTCATTGCCCCCAACCGCCATGGCGTACCCGGATTCGGGCAGAAATGGAA
CGAACAGATCAGTGGCGACTATGGTGGCCAGAATATGCGTGACTATCTGA
CTGCCGTAGACGAAATGAAGAAAGAACCCTATGTCGATGGCGATCGCATC
GGAGCGGTGGGTGCAAGCTACGGTGGCTTCTCCGTCTATTGGTTGGCAGG
CCATCACGATAAGCGATTTGCCGCTTTTATCGCTCATGCCGGTATCTTCA
ATCTGGAGATGCAGTACGCCACGACGGAAGAGATGTGGTTTGCTAATTGG
GATATAGGCGGTCCTTTCTGGGAGAAGGATAATGTAGTGGCTCAGCGTAC
CTATGCAACTTCGCCACACAAGTTCGTGCAGAATTGGGATACACCTATCC
TCATGATTCATGGCGAACTGGACTTCCGCATTCTCGCTTCACAGGCTATG
GCTGCTTTCGATGCAGCACAGCTTCGTGGCGTTCCGAGCGAGATGTTGAT
CTATCCGGATGAAAACCACTGGGTACTCCAACCGCAGAATGCATTGCTAT
TCCATCGTACATTCTTCGGCTGGTTGGATCGTTGGCTGAAGAAG

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