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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0797 IGR0800 IGR0803 IGR0804 IGR0798 IGR0799 IGR0805 IGR0806 IGR0802 IGR0801 PG0941.1 tpr, - PG0938 PG0936 PG0939 PG0940 PG0937 PG0933 PG0934 PG0935 prc,tsp, - PG0942 pal, - PG0941 PG0941.1 tpr, - PG0938 PG0936 PG0939 PG0940 PG0937 PG0933 PG0934 PG0935 prc,tsp, - PG0942 pal, - PG0941 PG0941.1 tpr, - PG0938 PG0940 PG0937 PG0934 PG0935 prc,tsp, - PG0942 pal, - PG0941 PG0936 PG0939 PG0933


LANL Gene ID: PG0938

GenBank Locus Tag: PG1055

DNA Molecule Name:
1  

GenBank ID:
34540792

Gene Name:
tpr  

Definition:
thiol protease

Cellular Location:
Outer membrane, Periplasm [Evidence]

Gene Start:
1122739

Gene Stop:
1121297

Gene Length:
1443

Molecular Weight*:
54980

pI*:
5.50

Net Charge*:
-5.23

EC:
3.4.22.-  

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0006508    proteolysis

Cellular component
  GO:0005622    intracellular

Molecular function
  GO:0004197    cysteine-type endopeptidase activity
  GO:0004198    calpain activity


Pathway: pathway table

Primary Evidence:
Bourgeau,G., Lapointe,H., Peloquin,P. and Mayrand,D. 1992. Cloning, expression and sequencing of a protease gene (tpr) from Porphyromonas gingivalis strain W83 in Escherichia coli. Infect. Immun. 60: 3186-3192. PubMed: 1322368.

Comment:
TIGR ID: PG1055

Human Oral Microbiome Database:
View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
PG0938 is essentially identical to a previously sequenced protein of P.gingivalis in Genbank AAA25652, identified as thiol protease.

Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540792|ref|NP_905271.1|  thiol protease [Porphyromonas ...   942   0.0  
 gi|150852|gb|AAA25652.1|  thiol protease [Porphyromonas ging...   937   0.0  
 gi|39946748|ref|XP_362911.1|  hypothetical protein MGG_08526...    92   6e-17


InterPro Summary:  InterProScan

InterPro
IPR000169
Active_site
Peptidase, cysteine peptidase active site
PS00139 [223-234]T 0.0 PS00139 THIOL_PROTEASE_CYS THIOL_PROTEASE_CYS
InterPro
IPR001300
Family
Peptidase C2, calpain
PR00704 [223-239]T 4.7E-5 PR00704 CALPAIN[297-320]T 4.7E-5 PR00704 CALPAIN CALPAIN
PF00648 [195-471]T 2.69999998300297 PF00648 Peptidase_C2 Peptidase_C2
SM00230 [154-481]T 0.21 SM00230 CysPc CysPc
PS50203 [221-481]T 0.0 PS50203 CALPAIN_CAT CALPAIN_CAT
noIPR
unintegrated
unintegrated
SSF54001 [122-479]T 2.6000000000000003E-44 SSF54001 SSF54001 SSF54001


COGS Summary:  COGS Search
No hit to the COGs database.
Blocks Summary:  Blocks Search
***** PR00704 (Calpain cysteine protease (C2) family signature) with a combined E-value of 4.5e-08.
    PR00704C    223-239
    PR00704E    297-320
    PR00704G    348-369


 ProDom Summary:  Protein Domain Search
No significant hit to the ProDom database.

Paralogs:  Local Blast Search
No paralogs found in P. gingivalis.

Pfam Summary:  Pfam Search
No significant hits to the Pfam 11.0 database

 Structural Feature(s):
Feature Type  Start  Stop
non-globular  
1  
56
non-globular  
124  
199
transmembrane  
227  
244
transmembrane  
230  
246
transmembrane  
400  
417

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
MEKKLVPQSISKERLQKLEAQATLTPQQEEAKARKIEREKARLKELNIPT
ESKESKDCSPAGMINPYALTEVILERPLDWSNPRTTDIVERVLGSSMQDL
SKGDSVLRAGRDQNAEVKIVDSVLTKTQRGQDGLERILESFNDYDMPPEE
KEEAAPKAKKAAQKLDIDDLREQALSSTTITKEISKIILPTKNLRDDNNT
VHQYREVGFQSNGAHNLWDTVVQGIAGDCYMLAALSAIAWVWPALLNMDV
DIMSNQDEWRLYRYFIGRSKQTYARPSGSGTSTNEILQEGYYKVPIFARS
RYWFNGEYWPALFEQAYANWKFPNDSKYNAILQIGGGWPEEALCELSGDS
WFTSSGKLMLSSFTDLSLLNFMKSMCYSWKTIKPMVIVTPCWEPLPPMMP
GIAAYHAYTVLGYTVSNGAYYLIIRNPWGVTEPTGDGVLSKRDWVIHFDN
MKWFNLSKDDGIFALRLDKVRENFWYIAYMY

Gene Nucleotide Sequence:  Sequence Viewer
ATGGAAAAGAAATTAGTACCGCAATCCATTTCAAAAGAAAGATTGCAGAA
GTTAGAAGCACAAGCAACTCTTACTCCTCAACAAGAGGAAGCGAAAGCCC
GTAAAATCGAAAGAGAGAAAGCCAGACTAAAAGAACTGAACATTCCTACC
GAATCTAAAGAATCCAAAGATTGCAGCCCTGCAGGGATGATCAATCCATA
TGCACTTACTGAAGTCATTTTAGAAAGACCATTGGATTGGAGCAACCCAC
GGACTACCGATATAGTAGAACGCGTGTTGGGTTCAAGCATGCAAGATCTA
TCCAAAGGCGACTCTGTATTAAGAGCCGGAAGAGACCAAAATGCTGAGGT
CAAAATCGTGGATTCAGTTTTGACTAAGACCCAAAGAGGGCAGGACGGTC
TGGAGAGAATCCTTGAATCGTTCAACGATTATGACATGCCTCCCGAAGAA
AAAGAAGAAGCTGCTCCAAAGGCAAAAAAAGCAGCCCAAAAACTCGACAT
CGACGACCTCAGAGAGCAAGCACTGTCATCCACTACTATCACAAAGGAGA
TCAGCAAGATCATCCTTCCGACAAAAAATTTAAGAGATGATAATAATACA
GTACATCAGTACAGAGAAGTCGGCTTCCAAAGCAATGGAGCACACAACTT
GTGGGACACAGTAGTTCAAGGAATCGCTGGCGATTGTTACATGCTTGCAG
CTTTGTCGGCTATAGCTTGGGTATGGCCCGCTCTATTGAATATGGATGTG
GACATCATGTCTAATCAAGATGAATGGCGACTCTATCGCTACTTCATAGG
GCGCTCTAAACAGACATATGCACGCCCGTCGGGATCAGGTACCTCCACCA
ATGAAATTCTTCAGGAAGGATATTACAAAGTTCCGATCTTTGCAAGGAGT
CGCTATTGGTTCAACGGAGAATACTGGCCGGCTCTTTTCGAACAAGCATA
TGCCAATTGGAAATTCCCTAATGATTCCAAATACAACGCAATCCTACAGA
TTGGAGGTGGCTGGCCTGAGGAAGCACTTTGCGAGCTGAGTGGAGATAGC
TGGTTTACCTCCTCGGGAAAACTCATGCTTTCTTCTTTCACAGATCTGTC
ATTGCTGAATTTTATGAAAAGCATGTGCTATAGTTGGAAGACGATAAAAC
CGATGGTGATTGTAACCCCATGCTGGGAGCCTCTACCTCCTATGATGCCC
GGAATTGCAGCATACCATGCCTATACAGTTTTGGGATATACAGTTTCCAA
TGGAGCCTATTACCTGATTATCCGCAATCCATGGGGAGTGACTGAGCCAA
CAGGAGATGGAGTGCTAAGCAAAAGAGATTGGGTTATCCACTTCGATAAT
ATGAAGTGGTTCAATCTATCCAAAGACGATGGCATTTTCGCACTCCGACT
TGATAAAGTGAGAGAGAACTTCTGGTACATCGCATATATGTAT

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