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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR0803 IGR0804 IGR0809 IGR0805 IGR0806 IGR0807 IGR0802 IGR0808 PG0941.1 ISPg2, - PG0943 tpr, - PG0938 PG0939 PG0945 PG0940 pyrD, - PG0947 prc,tsp, - PG0942 pal, - PG0941 PG0941.1 ISPg2, - PG0943 tpr, - PG0938 PG0939 PG0945 PG0940 pyrD, - PG0947 prc,tsp, - PG0942 pal, - PG0941 PG0941.1 ISPg2, - PG0943 tpr, - PG0938 PG0940 prc,tsp, - PG0942 pal, - PG0941 pyrD, - PG0946 PG0945 pyrD, - PG0947 PG0939 pyrD, - PG0946


LANL Gene ID: PG0942

GenBank Locus Tag: PG1060

DNA Molecule Name:
1  

GenBank ID:
34540797

Gene Name:
prc  tsp  

Definition:
probable tail-specific protease

Cellular Location:
Cytoplasm, Outer membrane, Extracellular [Evidence]

Gene Start:
1126800

Gene Stop:
1128506

Gene Length:
1707

Molecular Weight*:
63526

pI*:
9.80

Net Charge*:
10.87

EC:
3.4.21.102  

Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

Gene Ontology:
Biological process
  GO:0006508    proteolysis

Molecular function
  GO:0005515    protein binding
  GO:0008236    serine-type peptidase activity


Pathway: pathway table

Comment:
Gapped BLAST hits are variable in C-terminal end of orf.

TIGR ID: PG1060

Proteomic Data: Proteomic Data Search
TIGR Annotationcarboxyl-terminal protease, GroupM (protein fate)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG10602.531.9e-121.965.7e-081.511.4e-101.965.7e-08
LANLPG09425.763.892.854.04
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Numerous significant hits to carboxyl-terminal proteinase in gapped BLAST; e.g. residues 1-413 are 34% similar to pirF70369 carboxyl-terminal proteinase of Aquifex aeolicus, residues 11-360 are 36% similar to gbAAB61766.1 protease of Bartonella bacilliformis, residues 6-360 are 35% similar to pirD71827 carboxyl-terminal proteinase of Helicobacter pylori (strain J99).

This sequence is similar to BT2798.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|34540797|ref|NP_905276.1|  carboxyl-terminal protease [Po...  1098   0.0  
 gi|150010231|ref|YP_001304974.1|  carboxy-terminal processin...   531   e-149
 gi|154491879|ref|ZP_02031505.1|  hypothetical protein PARMER...   518   e-145
 gi|156858933|gb|EDO52364.1|  hypothetical protein BACUNI_039...   494   e-138
 gi|153805850|ref|ZP_01958518.1|  hypothetical protein BACCAC...   482   e-134
 gi|29348207|ref|NP_811710.1|  carboxy-terminal processing pr...   478   e-133
 gi|156110391|gb|EDO12136.1|  hypothetical protein BACOVA_020...   477   e-133
 gi|53715654|ref|YP_101646.1|  carboxy-terminal processing pr...   461   e-128
 gi|60683593|ref|YP_213737.1|  putative carboxy-terminal proc...   457   e-127
 gi|150003412|ref|YP_001298156.1|  carboxy-terminal processin...   437   e-121


InterPro Summary:  InterProScan

InterPro
IPR001478
Domain
PDZ/DHR/GLGF
PF00595 [95-174]T 6.20000124972809E-7 PF00595 PDZ PDZ
SM00228 [105-177]T 3.5000000000002E-11 SM00228 PDZ PDZ
PS50106 [95-168]T 0.0 PS50106 PDZ PDZ
SSF50156 [89-185]T 6.3E-15 SSF50156 PDZ PDZ
InterPro
IPR004447
Family
Peptidase S41A, C-terminal protease
TIGR00225 [53-390]T 1.20491997095902E-69 TIGR00225 prc prc
InterPro
IPR005151
Domain
Peptidase S41
PF03572 [205-366]T 2.0000139277203602E-68 PF03572 Peptidase_S41 Peptidase_S41
SM00245 [179-367]T 3.40000000000035E-58 SM00245 TSPc TSPc
noIPR
unintegrated
unintegrated
G3DSA:2.30.42.10 [99-178]T 3.49999851148922E-7 G3DSA:2.30.42.10 G3DSA:2.30.42.10 G3DSA:2.30.42.10
G3DSA:3.90.226.10 [182-430]T 5.899988094056819E-48 G3DSA:3.90.226.10 G3DSA:3.90.226.10 G3DSA:3.90.226.10
PTHR19964 [110-168]T 5.6999970878395E-5 PTHR19964 PTHR19964 PTHR19964
PS51257 [1-23]T 0.0 PS51257 PROKAR_LIPOPROTEIN PROKAR_LIPOPROTEIN
SSF52096 [42-413]T 3.2E-68 SSF52096 SSF52096 SSF52096


COGS Summary:  COGS Search
BeTs to 10 clades of COG0793
COG name: Periplasmic protease
Functional Class: M
The phylogenetic pattern of COG0793 is -----qvCeB-huj--olinx
Number of proteins in this genome belonging to this COG is 4
Blocks Summary:  Blocks Search
No significant hit to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 175-360 are 43% similar to a (PROTEASE CARBOXYL-TERMINAL PRECURSOR) protein domain (PD004132 which is seen in CTPA_BARBA.


Paralogs:  Local Blast Search
Residues 49-551 are 30% similar to PG1617, a predicted carboxyl-terminal proteinase. Similarities are also seen to PG0214, a predicted carboxyl-terminal protease. Weaker similarities are seen to PG1417, a hypothetical protein.

Pfam Summary:  Pfam Search
Residues 95 to 174 (E-value = 1.1e-08) place PG0942 in the PDZ family which is described as PDZ domain (Also known as DHR or GLGF) (PF00595)
Residues 204 to 368 (E-value = 8.9e-70) place PG0942 in the Peptidase_S41 family which is described as Peptidase family S41B (PF03572)

 Structural Feature(s):
Feature Type  Start  Stop
may be a lipoprotein  
  
gram negative signal  
1  
24
coil-coil  
453  
519

Top PDB Hits:
-53% similar to PDB:1FC6 PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE (E_value = 7.5E_39);
-53% similar to PDB:1FC7 PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE (E_value = 9.7E_39);
-53% similar to PDB:1FC9 PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE (E_value = 9.7E_39);
-53% similar to PDB:1FCF PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE (E_value = 9.7E_39);

Gene Protein Sequence:
MKKTNLFLSLLVIFITGSFMTACAQKSKTNKLTEEDRSRNEYVQSMDVLS
NIIGNVRLYFVDTISIKHMTRRGIDAMLGGLDPYTEYIPYEEMDELKLMT
TGEYAGVGAIISQRPDSAVIIQRPMEGMPADEAGLIAGDRILTIDGKDFR
KSTTPKVSQALKGIAGTVAKVTVMRYGETKPRTFSVKRQKVIMNSVTYSG
MLDGSIGYIRLNNFTDKSAEEVRTALLDLRDKQGAKGLILDLRGNGGGLM
QAAIEIVNLFVPKGKEVVTTKGRIAESASVFRTLTEPIDTKLPIVVLIDG
QSASSSEIVAGALQDMDRAVLMGQKSYGKGLVQTTRQLPYNGVIKLTTAK
YYIPSGRCIQRLDYSRTNRTGMATAIPDSLHKIFYTAAGRRVEDAGGILP
DIEVKQDTAATLLYYMAINNDVFDFVTGYVLKHKTIAKPEDFSITNEDYA
AFCKMMEEKKFDYDRQSGKMLDKLEELAKIEGYLPEANSELKALREKLKP
NLSRDLLRFKKEITNYLNNEIVTRYYYERGSIRQSLPEDKVVKEAIKLLK
DHPEQIRQILAAPKAENKG

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAAAGACCAATCTGTTTTTATCTCTGCTGGTGATCTTTATCACCGG
TAGTTTTATGACTGCCTGTGCACAGAAGTCCAAGACGAACAAACTCACCG
AAGAAGATCGGAGCCGCAATGAGTATGTACAGTCGATGGATGTGCTTAGC
AATATTATCGGTAACGTCAGGCTGTATTTCGTCGATACCATAAGTATCAA
ACATATGACTCGGCGTGGTATAGATGCGATGTTGGGCGGGCTTGACCCCT
ATACCGAATACATTCCTTACGAGGAAATGGATGAACTGAAATTGATGACT
ACGGGAGAGTATGCCGGAGTCGGAGCTATCATATCGCAGCGCCCGGATAG
TGCTGTGATTATCCAGAGACCTATGGAAGGTATGCCCGCAGACGAAGCAG
GATTGATAGCAGGCGACCGCATCCTGACTATCGATGGGAAAGACTTCCGC
AAATCCACCACACCGAAAGTAAGCCAAGCACTGAAAGGGATAGCCGGTAC
TGTTGCAAAGGTGACAGTAATGCGCTATGGCGAAACCAAACCTCGTACTT
TTTCCGTGAAACGTCAAAAAGTGATTATGAATTCCGTCACTTACAGCGGA
ATGCTCGATGGCTCGATAGGATATATCCGCTTGAACAACTTTACGGACAA
AAGTGCAGAAGAGGTGCGCACGGCCTTGTTGGATCTTCGTGACAAACAAG
GAGCGAAAGGTCTCATTTTGGATTTAAGAGGCAATGGTGGCGGACTGATG
CAGGCTGCTATCGAGATAGTCAATCTGTTCGTCCCTAAGGGCAAAGAGGT
GGTAACGACCAAAGGTCGCATTGCAGAGTCGGCGTCCGTATTTCGCACAT
TGACTGAACCGATCGACACGAAACTCCCGATAGTAGTCCTGATCGATGGA
CAATCGGCATCTTCCTCGGAGATTGTAGCCGGAGCACTGCAGGATATGGA
CAGGGCTGTACTGATGGGACAAAAGAGCTATGGCAAAGGGCTTGTACAAA
CGACTCGTCAGCTACCATACAACGGCGTGATCAAATTGACTACGGCCAAG
TACTACATCCCAAGCGGACGTTGTATTCAGCGTTTGGACTACAGCCGCAC
CAATCGGACAGGTATGGCAACGGCCATTCCTGACAGTCTGCACAAAATCT
TTTACACTGCTGCCGGAAGACGTGTAGAAGATGCAGGAGGAATCCTGCCT
GACATCGAGGTCAAACAAGATACAGCTGCGACATTACTTTATTATATGGC
CATCAATAATGACGTTTTCGATTTCGTCACAGGTTATGTGCTCAAGCATA
AAACGATTGCCAAGCCGGAGGATTTTTCCATAACGAACGAGGACTATGCA
GCTTTCTGCAAGATGATGGAAGAAAAGAAATTTGACTATGATCGCCAGAG
TGGCAAGATGCTTGACAAACTGGAGGAACTGGCTAAGATAGAAGGCTACC
TGCCGGAAGCCAACTCGGAGCTTAAAGCACTACGCGAAAAGCTAAAACCC
AACCTGTCGCGTGATCTGCTACGATTCAAAAAGGAGATAACAAACTATCT
CAACAATGAGATTGTCACTCGCTATTATTATGAGCGAGGCAGTATCCGCC
AGAGTTTGCCGGAAGATAAGGTAGTCAAAGAAGCTATTAAGCTGCTGAAG
GACCATCCGGAACAAATTCGACAGATCCTTGCAGCTCCGAAAGCAGAGAA
TAAAGGG

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