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Record: 1 of 1 MiniMap

LANL Gene ID: PG1164GenBank Locus Tag: PG1326DNA Molecule Name: 1 Genomic Island ID: 24 GenBank ID: 34541018 Gene Name: Definition: outer membrane receptor Cellular Location: Outer membrane, Cytoplasm, Extracellular [Evidence] Gene Start: 1404101 Gene Stop: 1405231 Gene Length: 1131 Molecular Weight*: 42254 pI*: 5.50 Net Charge*: -5.88 EC: Functional Class: Cell envelope Gene Ontology: Biological process GO:0009405 pathogenesis Pathway: pathway table Primary Evidence: See href="http://linker.lanl.gov/readonly/oragen/bacteria/pgin/hemagglutinin/summ_hemag.htm">Proteases/Hemagglutinin Analysis Ross BC, Czajkowski L, Hocking D, Margetts M, Webb E, Rothel L, Patterson M, Agius C, Camuglia S, Reynolds E, Littlejohn T, Gaeta B, Ng A, Kuczek ES, Mattick JS, Gearing D, Barr IG, Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis, Vaccine 2001 Jul 20;19(30): 4135-42, PMID: 11457538. Ross,B., Barr,I., Patterson,M., Agius,C., Rothel,L., Margetts,M., Hocking,D. and Webb,E. P. gingivalis polypeptides and nucleic acids. Patent: Australia (AU 98/01023)-PCT 10-DEC-1998. Shibata,Y., Hayakawa,M., Takiguchi,H., Shiroza,T. and Abiko,Y., Determination and characterization of the hemagglutinin-associated short motifs found in Porphyromonas gingivalis multiple gene products, J. Biol. Chem. 274 (8), 5012-5020 (1999), PubMed: 9988746. Comment: Ross, et al.(2001) select PG1164 as one of fifteen vaccine candidate antigens, based on in vitro and in vivo laboratory studies of 120 candidates screened by bioinformatics techniques from the whole W50 genome. TIGR ID: PG1326 Proteomic Data: Proteomic Data Search

TIGR Annotation		hemagglutinin, putative, GroupD (cellular processes)
ORF #		PG-PP/PG-PPC1				PG-PP/PG-PPC2
		Spectral Count		Peptide Intensity		Spectral Count		Peptide Intensity
		Pro	qVal	Pro	qVal	Pro	qVal	Pro	qVal
TIGR	PG1326	-0.94	0.018	-0.96	0.011	2.30	0.00018	-0.96	0.011
LANL	PG1164	0.52		0.51		4.91		4.71
Consensus		SP1		IP1		SP2		IP2

Human Oral Microbiome Database: View in HOMD Genome Viewer Blast Summary: PSI-Blast Search PG1164 is identical to the previously sequenced P.gingivalis, strain W50, protein in GenBANK, AAF81413, hypothetical outer membrane protein PG27. No other significant hits in gapped BLAST except to paralogs. Top Blast Hits: Updated monthly Click here to view the entire PsiBlast results. gi|34541018|ref|NP_905497.1| hemagglutinin, putative [Porph... 726 0.0 gi|8925307|gb|AAF81413.1|AF237555_1 hypothetical outer memb... 642 0.0 gi|1514621|emb|CAA68897.1| TonB-linked adhesin [Porphyromon... 286 1e-75 gi|3869077|dbj|BAA34341.1| 130k-HMGD [Porphyromonas gingiva... 283 1e-74 gi|2182812|gb|AAB60809.1| lysine-specific cysteine proteina... 283 1e-74 gi|38605638|sp|P59915|HAGA1_PORGI Hemagglutinin A precursor 281 4e-74 gi|34541453|ref|NP_905932.1| hemagglutinin protein HagA [Po... 281 4e-74 gi|6225493|sp|Q51845|HAGA2_PORGI Hemagglutinin A precursor ... 281 5e-74 gi|1314326|gb|AAB06565.1| porphypain 281 5e-74 gi|2738803|gb|AAC26523.1| lysine specific cysteine protease... 278 4e-73 InterPro Summary: InterProScan InterPro IPR011628 Domain Cleaved adhesin PF07675 Cleaved_Adhesin InterPro IPR013237 Domain Phage P4 alpha, zinc-binding SM00778 no description noIPR unintegrated unintegrated signalp signal-peptide COGS Summary: COGS Search No hit to the COGs database. Blocks Summary: Blocks Search ***** PF01364 (Peptidase family C25) with a combined E-value of 9.2e-10. PF01364F 279-332 PF01364G 335-373 ProDom Summary: Protein Domain Search Residues 247-302 are 48% similar to a (PROTEASE PRECURSOR SIGNAL THIOL HEMAGGLUTININ REPEAT) protein domain (PD002028 which is seen in O52050_PORGI. Residues 311-377 are 44% similar to a (PROTEASE PRECURSOR THIOL SIGNAL) protein domain (PD004371 which is seen in P72194_PORGI. Residues 38-229 are 54% similar to a (PROTEASE PRECURSOR SIGNAL HEMAGGLUTININ THIOL REPEAT) protein domain (PD001858 which is seen in HAGA_PORGI. Paralogs: Local Blast Search Residues 38-377 are similar to multiple domains of PG1602, a predicted hemagglutinin/adhesin precursor; HAGA, domains each beginning at residues 201, 471, 688, 925, 1140, 1377, 1592 and 1829. Strong similarities are also seen to domains of: PG1606 hemagglutinin-related protein, PG1605 porphypain polyprotein; lys-X proteinase/hemagglutinin, PG1768 arginine-specific cysteine proteinase: gingipain R1, PG0376 possible outer membrane protein, PG1922, PG0461 arginine-specific cysteine proteinase: gingipain R2. Pfam Summary: Pfam Search No significant hits to the Pfam 11.0 database Structural Feature(s): Feature Type Start Stop No predicted structural features. Top PDB Hits: No significant hits to the PDB database (E-value < E-10). Gene Protein Sequence: LFNHKKSWYETFQFYLVVFRSGFILLCENTLAQQKTEEFAPVSDLRAEAY GSTVFLHWTPPYDNPMIPLSESFESGIPAIWKTIDADGDGYNWMHLTNFT GQSGLCVSSASYIGGVGALTPDNYLITPELKLPTDALVEIIYWVCTQDLT APSEHYAVYSSSTGNNAADFVNLLYEETLTAKRIQSPELIRGNRTQGVWY QRKVVLPNDTKYVAFRHFNSTDNFWLNLDEVSILYTPLPRRAPCPHPGGY TYSVFRDGQKIASGLSALAYIDTDVPYGTQDYCVQVNYLQGDSYKVCKNI VVANSANIYGADKPFALTVVGKTIVASAFKGEITLYDIRGRLIASGCDTL RYKAENGFYLIKIQVNGTVYTEKIQIQ Gene Nucleotide Sequence: Sequence Viewer TTGTTTAATCATAAAAAATCATGGTATGAAACATTTCAATTTTATCTCGT TGTTTTCCGCTCTGGCTTTATTCTTTTGTGTGAAAATACCCTTGCACAAC AAAAAACAGAGGAGTTTGCACCTGTGTCGGATTTACGTGCAGAAGCGTAC GGCTCTACCGTTTTCCTCCACTGGACTCCGCCGTATGACAATCCGATGAT TCCTCTAAGCGAGAGTTTTGAATCAGGTATTCCAGCTATATGGAAGACCA TTGACGCAGATGGCGATGGCTATAATTGGATGCATTTGACCAATTTCACG GGACAGAGTGGTCTCTGTGTCTCTTCGGCTTCATACATAGGCGGCGTCGG AGCTTTGACTCCGGACAATTATCTGATAACACCCGAATTAAAACTACCCA CAGACGCGTTGGTGGAAATAATCTATTGGGTATGTACTCAAGATCTCACT GCTCCATCGGAGCACTATGCCGTTTATTCCTCTTCTACAGGCAATAATGC TGCTGACTTTGTTAATCTCTTATATGAAGAGACTTTGACTGCCAAACGGA TACAATCCCCCGAGTTGATCCGCGGAAATCGGACACAAGGTGTTTGGTAT CAAAGAAAGGTGGTACTCCCTAACGATACTAAATATGTTGCTTTCCGCCA TTTTAATTCCACGGATAATTTCTGGCTCAATTTGGATGAAGTATCTATCC TGTATACCCCTCTTCCCCGAAGAGCTCCGTGTCCGCATCCGGGTGGTTAC ACTTATTCTGTATTCCGTGATGGACAAAAGATAGCGAGTGGATTGTCGGC ATTGGCATATATCGATACGGATGTACCGTATGGGACTCAAGACTATTGTG TCCAAGTCAATTATCTGCAAGGAGACTCGTATAAAGTCTGCAAAAATATA GTGGTGGCAAATTCTGCAAACATCTATGGGGCGGATAAGCCTTTTGCGTT GACCGTGGTTGGCAAGACCATTGTAGCGAGTGCTTTCAAAGGAGAGATCA CTCTTTATGACATTCGTGGCCGGCTGATAGCTTCCGGCTGCGATACGCTT AGGTACAAAGCGGAAAATGGTTTTTACCTCATTAAAATACAGGTAAACGG AACTGTCTATACTGAGAAAATCCAAATCCAA Los Alamos National Laboratory • Est 1943 Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy

`Feature Type`	`Start`	`Stop`
`No predicted structural features.`