Search Results

Record: 1 of 1 MiniMap

LANL Gene ID: PG1602GenBank Locus Tag: PG1837DNA Molecule Name: 1 GenBank ID: 34541453Gene Name: hagA HbR Definition: hemagglutinin/adhesin precursor hagACellular Location: Extracellular, Outer membrane, Periplasm [Evidence]Gene Start: 1930303Gene Stop: 1936794Gene Length: 6492Molecular Weight*: 233403pI*: 4.50Net Charge*: -94.49EC: Functional Class: Cellular processes; Pathogenesis Gene Ontology: Biological process GO:0006260 DNA replication GO:0006281 DNA repair GO:0006310 DNA recombination GO:0009405 pathogenesis Molecular function GO:0003910 DNA ligase (ATP) activity GO:0005524 ATP bindingPathway: pathway tablePrimary Evidence: See href="http://linker.lanl.gov/readonly/oragen/bacteria/pgin/hemagglutinin/summ_hemag.htm">Proteases/Hemagglutinin Analysis. Veith,P., Talbo,G., Slakeski,N., Dashper,S., Moore,C.,Paolini,R., Reynolds,E., Major outer membrane proteins and proteolytic processing of RgpA, and Kgp of Porphyromonas gingivalis W50, Biochem J. 2002 (in press). Han,N., Whitlock,J. and Progulske-Fox,A. The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats Infect. Immun. 64 (10), 4000-4007 (1996) Shi Y, Kong W, Nakayama K. Human lactoferrin binds and removes the hemoglobin receptor protein of the periodontopathogen Porphyromonas gingivalis. J Biol Chem. 2000 Sep 29;275(39):30002-8. PMID: 10811640 Shibata Y, Hayakawa M, Takiguchi H, Shiroza T, Abiko Y. Determination and characterization of the hemagglutinin-associated short motifs found in Porphyromonas gingivalis multiple gene products. J Biol Chem. 1999 Feb 19;274(8):5012-20. PMID: 9988746Comment: PG1602 appears to be short one repeat unit. HagD and hagE are related to hagA: hagD is part of PG1605 (prtP) and hagE is part of PG1768 (prtR). HagB (PG1721) and hagC (PG1724) are hemagglutinin genes with no sequence similarity to hagA. The HbR protein is synthesized through peptide cleavage from hagA (Shi et al., 2000). Shibata et al. (1999) assert that 'PVQNLT" is a characteristic hemagglutinin-associated motif. See around residue 450. Veith et al. 2002 identified this protein by two-dimensional gel electrophoresis and peptide mass fingerprinting of outer membranes prepared from strain W50. They present the following results: Based on signal peptide sequence comparisons to PG0626, PG0627, PG1592, PG1840, PG0836, PG0023, PG1893, the mature N-terminus of this protein is predicted to be pyroglutamate. RgpA, Kgp and HagA were identified as fully processed domains. The N- and C-termini of many of these domains were identified by mass spectrometry and or N-terminal sequence analysis. It was found that gaps existed between many of the domains. The proposed domain structure of HagA is as follows: HagA signal peptide (1-25), HagA35 (26-351), HagA30 (366-625), HagA18 (658-803), HagA32 (820-1077), HagA18 (1137-1255), HagA32(1272-1529), HagA18 (1589-1707), HagA15 (1724-1856), HagA13 (1859-1978), HagA20 (1980-2164). TIGR ID: PG1837Proteomic Data: Proteomic Data Search

TIGR Annotation		hemagglutinin protein HagA, GroupD (cellular processes)
ORF #		PG-PP/PG-PPC1				PG-PP/PG-PPC2
		Spectral Count		Peptide Intensity		Spectral Count		Peptide Intensity
		Pro	qVal	Pro	qVal	Pro	qVal	Pro	qVal
TIGR	PG1837	-0.27	0.00015	0.34	0.15	0.04	0.24	0.34	0.15
LANL	PG1602	0.83		1.27		1.03		1.59
Consensus		SP1		IP1		SP2		IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer Blast Summary: PSI-Blast Search This sequence corresponds to the previously sequenced U41807 in GenBANK, a predicted hagA protein. Residues 1-2058 are 96% similar to residues 1-2042 of U41807, however the latter sequence has a complete length of 2628, suggesting that PG1602 is short one repeat unit (or there is a strain difference). Top Blast Hits: Updated monthly Click here to view the entire PsiBlast results. gi|38605638|sp|P59915|HAGA1_PORGI Hemagglutinin A precursor 4179 0.0 gi|34541453|ref|NP_905932.1| hemagglutinin protein HagA [Po... 4061 0.0 gi|6225493|sp|Q51845|HAGA2_PORGI Hemagglutinin A precursor ... 3769 0.0 gi|45593253|gb|AAS68176.1| Lys-gingipain [Porphyromonas gin... 1516 0.0 gi|2182812|gb|AAB60809.1| lysine-specific cysteine proteina... 1469 0.0 gi|1314326|gb|AAB06565.1| porphypain 1466 0.0 gi|2738803|gb|AAC26523.1| lysine specific cysteine protease... 1457 0.0 gi|3869077|dbj|BAA34341.1| 130k-HMGD [Porphyromonas gingiva... 1452 0.0 gi|1514621|emb|CAA68897.1| TonB-linked adhesin [Porphyromon... 1393 0.0 gi|1536824|dbj|BAA11870.1| Lys-gingipain [Porphyromonas gin... 1117 0.0InterPro Summary: InterProScan InterPro IPR000977 Family ATP-dependent DNA ligase PS00697 DNA_LIGASE_A1 InterPro IPR003961 Domain Fibronectin, type III SM00060 FN3 InterPro IPR011628 Domain Cleaved adhesin PF07675 Cleaved_Adhesin noIPR unintegrated unintegrated signalp signal-peptide COGS Summary: COGS Search No hit to the COGs database. Blocks Summary: Blocks Search ***** PF01364 (Peptidase family C25) with a combined E-value of 5.2e-85. PF01364A 1127-1176 PF01364F 2068-2121 PF01364G 2122-2160 PF01364C 37-90 PF01364D 113-150 PF01364F 898-951 PF01364F 1350-1403 PF01364F 445-498 PF01364F 1802-1855 ProDom Summary: Protein Domain Search Residues 2028-2077 are identical to a (PROTEASE PRECURSOR SIGNAL THIOL HEMAGGLUTININ REPEAT) protein domain (PD002028 which is seen in HAGA_PORGI. Residues 2079-2164 are identical to a (PROTEASE PRECURSOR THIOL SIGNAL) protein domain (PD004371 which is seen in HAGA_PORGI. Residues 1825-2027 are 99% similar to a (PROTEASE PRECURSOR SIGNAL HEMAGGLUTININ THIOL REPEAT) protein domain (PD001858 which is seen in HAGA_PORGI. Residues 1759-1818 are 60% similar to a (PROTEASE THIOL REPEAT PRECURSOR) protein domain (PD013956 which is seen in P72197_PORGI. Paralogs: Local Blast Search PG1602 shows fragmentary (domain) similarity to: PG1768 arginine-specific cysteine proteinase PG1605 porphypain polyprotein PG1606 hemagglutinin-related protein PG1164 tonB linked outer membrane receptor PG0376 lysine-specific cysteine proteinase porphypain polyprotein PG1922 immunoreactive 32 kD antigen PG0461 arginine-specific cysteine proteinase Pfam Summary: Pfam Search No significant hits to the Pfam 11.0 database Structural Feature(s): Feature Type Start Stop cleavable signal 1 24 non-globular 455 557 non-globular 859 998 non-globular 1311 1450 Top PDB Hits: No significant hits to the PDB database (E-value < E-10). Gene Protein Sequence: MRKLNSLFSLAVLLSLLCWGQTAAAQGGPKTAPSVTHQAVQKGIRTSKAK DLRDPIPAGMARIILEAHDVWEDGTGYQMLWDADHNQYGASIPEESFWFA NGTIPAGLYDPFEYKVPVNADASFSPTNFVLDGTASADIPAGTYDYVIIN PNPGIIYIVGEGVSKGNDYVVEAGKTYHFTVQRQGPGDAASVVVTGEGGN EFAPVQNLQWSVSGQTVTLTWQAPASDKRTYVLNESFDTQTLPNGWTMID ADGDGHNWLSTINVYNTATHTGDGAMFSKSWTASSGAKIDLSPDNYLVTP KFTVPENGKLSYWVSSQEPWTNEHYGVFLSTTGNEAANFTIKLLEETLGS GKPAPMNLVKSEGVKAPAPYQERTIDLSAYAGQQVYLAFRHFGCTGIFRL YLDDVAVSGEGSSNDYTYTVYRDNVVIAQNLTATTFNQENVAPGQYNYCV EVKYTAGVSPKVCKDVTVEGSNEFAPVQNLTGSAVGQKVTLKWDAPNGTP NPNPGTTTLSESFENGIPASWKTIDADGDGNNWTTTPPPGGSSFAGHNSA ICVSSASYINFEGPQNPDNYLVTPELSLPNGGTLTFWVCAQDANYASEHY AVYASSTGNDASNFANALLEEVLTAKTVVTAPEAIRGTRVQGTWYQKTVQ LPAGTKYVAFRHFGCTDFFWINLDDVEIKANGKRADFTETFESSTHGEAP AEWTTIDADGDGQGWLCLSSGQLGWLTAHGGTNVVASFSWNGMALNPDNY LISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEETPN GINKGGARFGLSTEANGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLNY ILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHE YCVEVKYTAGVSPKECVNVTVDPVQFNPVQNLTGSAVGQKVTLKWDAPNG TPNPNPGTTTLSESFENGIPASWKTIDADGDGNNWTTTPPPGGTSFAGHN SAICVSSASYINFEGPQNPDNYLVTPELSLPNGGTLTFWVCAQDANYASE HYAVYASSTGNDASNFANALLEEVLTAKTVVTAPEAIRGTRVQGTWYQKT VQLPAGTKYVAFRHFGCTDFFWINLDDVEIKANGKRADFTETFESSTHGE APAEWTTIDADGDGQGWLCLSSGQLDWLTAHGGTNVVASFSWNGMALNPD NYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEET PNGINKGGARFGLSTEANGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDL NYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGN HEYCVEVKYTAGVSPKECVNVTVDPVQFNPVQNLTGSAVGQKVTLKWDAP NGTPNPNPGTTTLSESFENGIPASWKTIDADGDGNNWTTTPPPGGTSFAG HNSAICVSSASYINFEGPQNPDNYLVTPELSLPNGGTLTFWVCAQDANYA SEHYAVYASSTGNDASNFANALLEEVLTAKTVVTAPEAIRGTRVQGTWYQ KTVQLPAGTKYVAFRHFGCTDFFWINLDDVEIKANGKRADFTETFESSTH GEAPAEWTTIDADGDGQGWLCLSSGQLGWLTAHGGTNVVASFSWNGMALN PDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFE ETPNGINKGGARFGLSTEANGAKPQSVWIERTVDLPAGTKYVAFRHYNCS DLNYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVAT GNHEYCVEVKYTAGVSPKECVNVTINPTQFNPVQNLTAEQAPNSMDAILK WNAPASKRAEVLNEDFENGIPASWKTIDADGDGNNWTTTPPPGGSSFAGH NSAICVSSASYINFEGPQNPDNYLVTPELSLPGGGTLTFWVCAQDANYAS EHYAVYASSTGNDASNFANALLEEVLTAKTVVTAPEAIRGTRVQGTWYQK TVQLPAGTKYVAFRHFGCTDFFWINLDDVVITSGNAPSYTYTIYRNNTQI ASGVTETTYRDPDLATGFYTYGVKVVYPNGESAIETATLNITSLADVTAQ KPYTLTVVGKTITVTCQGEAMIYDMNGRRLAAGRNTVVYTAQGGHYAVMV VVDGKSYVEKLAVK Gene Nucleotide Sequence: Sequence Viewer ATGAGAAAATTGAATTCTTTATTTTCGCTCGCCGTCCTATTATCCCTATT GTGTTGGGGACAGACGGCTGCCGCACAGGGAGGGCCGAAGACTGCTCCTT CTGTGACGCACCAAGCGGTGCAGAAAGGTATTCGAACATCCAAGGCCAAG GATCTCCGAGATCCGATTCCTGCCGGTATGGCACGAATTATCTTGGAGGC TCACGATGTATGGGAAGACGGCACAGGCTATCAAATGCTCTGGGATGCAG ATCACAATCAGTACGGCGCATCCATTCCCGAAGAATCTTTTTGGTTTGCC AACGGAACGATCCCGGCCGGTCTTTACGATCCTTTCGAGTATAAAGTTCC GGTCAATGCCGATGCATCTTTTTCTCCCACGAATTTCGTGCTTGATGGAA CAGCATCAGCCGATATTCCTGCCGGCACTTATGACTATGTAATCATTAAC CCCAATCCTGGCATAATATATATAGTAGGAGAGGGTGTCTCCAAAGGTAA CGATTATGTGGTAGAGGCCGGTAAGACTTATCATTTCACTGTCCAACGAC AAGGCCCCGGCGATGCTGCGTCCGTTGTAGTGACCGGAGAAGGTGGCAAT GAATTCGCTCCCGTACAGAATCTCCAATGGTCTGTATCCGGGCAGACAGT GACCCTCACTTGGCAAGCCCCCGCATCCGACAAACGGACTTATGTGTTGA ACGAAAGCTTCGATACGCAAACGCTTCCTAACGGCTGGACAATGATCGAT GCTGATGGTGATGGTCACAATTGGCTATCTACAATAAACGTTTACAACAC TGCTACTCATACAGGTGACGGTGCTATGTTTAGCAAATCATGGACAGCTA GCAGTGGTGCAAAAATTGATTTGAGTCCTGACAACTATTTGGTAACTCCT AAGTTTACGGTTCCTGAGAATGGTAAACTTTCTTATTGGGTTTCATCTCA AGAGCCTTGGACTAATGAGCATTATGGAGTGTTCTTGTCCACAACCGGAA ACGAGGCTGCAAACTTTACGATAAAGCTGCTGGAAGAAACCCTCGGATCC GGCAAACCTGCTCCGATGAACTTGGTGAAGAGTGAAGGAGTAAAGGCTCC GGCACCTTATCAGGAAAGAACCATCGATCTCTCTGCCTATGCCGGACAAC AGGTGTACTTGGCATTCCGTCATTTCGGCTGTACAGGTATATTCCGTCTT TATCTTGATGACGTGGCTGTTTCTGGTGAAGGTTCTTCCAACGACTACAC GTACACGGTATATCGTGACAATGTTGTTATCGCCCAGAATCTCACGGCAA CGACATTCAATCAGGAAAATGTAGCTCCCGGCCAGTACAACTACTGTGTT GAAGTTAAGTACACAGCCGGCGTATCTCCGAAGGTATGTAAAGACGTTAC GGTAGAAGGATCCAATGAATTTGCTCCTGTACAGAACCTGACCGGTAGTG CAGTCGGCCAGAAAGTAACGCTCAAGTGGGATGCACCTAATGGTACCCCG AATCCGAATCCGGGAACAACAACACTTTCCGAATCATTCGAAAATGGTAT TCCTGCCTCATGGAAGACGATCGATGCAGACGGTGACGGCAACAATTGGA CGACGACCCCTCCTCCCGGAGGCTCCTCTTTTGCAGGTCACAACAGTGCA ATCTGTGTCTCTTCGGCTTCTTATATCAACTTTGAAGGCCCTCAGAACCC TGATAACTATCTGGTTACACCGGAGCTTTCTCTTCCTAACGGAGGAACGC TTACTTTCTGGGTATGTGCACAAGATGCCAATTATGCATCAGAGCACTAT GCCGTGTATGCATCTTCTACGGGTAACGACGCTTCCAACTTCGCCAACGC TTTGTTGGAAGAAGTGCTGACGGCCAAGACAGTTGTTACGGCACCGGAAG CCATTCGTGGCACTCGTGTTCAGGGCACCTGGTATCAAAAGACGGTACAG TTGCCTGCGGGTACTAAGTATGTTGCCTTCCGTCACTTCGGCTGTACGGA CTTCTTCTGGATCAACCTCGATGATGTTGAGATCAAGGCCAACGGCAAGC GCGCAGACTTCACGGAAACGTTCGAGTCTTCTACTCATGGAGAGGCACCA GCGGAATGGACTACTATCGATGCCGATGGCGATGGTCAGGGTTGGCTCTG TCTGTCTTCCGGACAATTGGGATGGCTGACAGCTCATGGCGGCACCAACG TAGTAGCCTCTTTCTCATGGAATGGAATGGCTTTGAATCCTGATAACTAT CTCATCTCAAAGGATGTTACAGGCGCAACGAAGGTAAAGTACTACTATGC AGTCAACGACGGTTTTCCCGGGGATCACTATGCGGTGATGATCTCCAAGA CGGGCACGAACGCCGGAGACTTCACGGTCGTTTTCGAAGAAACGCCTAAC GGAATAAATAAGGGCGGAGCAAGATTCGGTCTTTCCACGGAAGCCAATGG CGCCAAACCTCAAAGTGTATGGATCGAGCGTACGGTAGATTTGCCTGCGG GCACGAAGTATGTTGCTTTCCGTCACTACAATTGCTCGGATTTGAACTAC ATTCTTTTGGATGATATTCAGTTCACCATGGGTGGCAGCCCCACCCCGAC CGATTATACCTACACGGTGTATCGTGATGGTACGAAGATCAAGGAAGGTT TGACCGAAACGACCTTCGAAGAAGACGGCGTAGCTACGGGCAATCATGAG TATTGCGTGGAAGTGAAGTACACAGCCGGCGTATCTCCGAAAGAGTGTGT AAACGTAACTGTTGATCCTGTGCAGTTTAATCCTGTACAGAACCTGACCG GTAGTGCAGTAGGTCAGAAAGTAACGCTTAAGTGGGATGCACCTAATGGT ACCCCGAATCCGAATCCCGGAACAACTACACTTTCCGAATCATTCGAAAA TGGTATTCCTGCCTCATGGAAGACGATCGATGCAGACGGTGACGGCAACA ATTGGACGACGACCCCTCCTCCCGGAGGCACCTCTTTTGCAGGTCACAAC AGTGCGATCTGTGTCTCTTCGGCTTCTTATATCAACTTTGAAGGCCCTCA GAACCCTGATAACTATCTGGTTACACCGGAGCTATCTCTTCCTAACGGAG GAACGCTTACTTTCTGGGTATGTGCACAAGATGCCAATTATGCATCAGAG CACTATGCCGTGTATGCATCTTCTACGGGTAACGACGCTTCCAACTTCGC CAACGCTTTGTTGGAAGAAGTGCTGACGGCCAAGACAGTTGTTACGGCAC CTGAAGCCATTCGTGGCACTCGTGTTCAGGGCACCTGGTATCAAAAGACG GTACAGTTGCCTGCGGGTACTAAGTATGTTGCCTTCCGTCACTTCGGCTG TACGGACTTCTTCTGGATCAACCTCGATGATGTTGAGATCAAGGCCAACG GCAAGCGCGCAGACTTCACGGAAACGTTCGAGTCTTCTACTCATGGAGAG GCACCAGCGGAATGGACTACTATCGATGCCGATGGCGATGGTCAGGGTTG GCTCTGTCTGTCTTCCGGACAATTGGACTGGCTGACAGCTCATGGCGGCA CCAACGTAGTAGCCTCTTTCTCATGGAATGGAATGGCTTTGAATCCTGAT AACTATCTCATCTCAAAGGATGTTACAGGCGCAACGAAGGTAAAGTACTA CTATGCAGTCAACGACGGTTTTCCCGGGGATCACTATGCGGTGATGATCT CCAAGACGGGCACGAACGCCGGAGACTTCACGGTTGTTTTCGAAGAAACG CCTAACGGAATAAATAAGGGCGGAGCAAGATTCGGTCTTTCCACGGAAGC CAATGGCGCCAAACCTCAAAGTGTATGGATCGAGCGTACGGTAGATTTGC CTGCGGGCACGAAGTATGTTGCTTTCCGTCACTACAATTGCTCGGATTTG AACTACATTCTTTTGGATGATATTCAGTTCACCATGGGTGGCAGCCCCAC CCCGACCGATTATACCTACACGGTGTATCGTGATGGTACGAAGATCAAGG AAGGTTTGACCGAAACGACCTTCGAAGAAGACGGCGTAGCTACGGGCAAT CATGAGTATTGCGTGGAAGTGAAGTACACAGCCGGCGTATCTCCGAAAGA GTGCGTAAACGTAACTGTTGATCCTGTGCAGTTCAATCCTGTACAGAACC TGACCGGTAGTGCAGTCGGCCAGAAAGTAACGCTCAAGTGGGATGCACCT AATGGTACCCCGAATCCGAATCCGGGAACAACAACACTTTCCGAATCATT CGAAAATGGTATTCCTGCCTCATGGAAGACGATCGATGCAGACGGTGACG GCAACAATTGGACGACGACCCCTCCTCCCGGAGGCACCTCTTTTGCAGGT CACAACAGTGCGATCTGTGTCTCTTCGGCTTCTTATATCAACTTTGAAGG CCCTCAGAACCCTGATAACTATCTGGTTACACCGGAGCTTTCTCTTCCTA ACGGAGGAACGCTTACTTTCTGGGTATGTGCACAAGATGCCAATTATGCA TCAGAGCACTATGCCGTGTATGCATCTTCTACGGGTAACGACGCTTCCAA CTTCGCCAACGCTTTGTTGGAAGAAGTGCTGACGGCCAAGACAGTTGTTA CGGCACCGGAAGCCATTCGTGGTACTCGTGTTCAGGGCACCTGGTATCAA AAGACGGTACAGTTGCCTGCGGGTACTAAGTATGTTGCCTTCCGTCACTT CGGCTGTACGGACTTCTTCTGGATCAACCTCGATGATGTTGAGATCAAGG CCAACGGCAAGCGCGCAGACTTCACGGAAACGTTCGAGTCTTCTACTCAT GGAGAGGCACCAGCGGAATGGACTACTATCGATGCCGATGGCGATGGTCA GGGTTGGCTCTGTCTGTCTTCCGGACAATTGGGATGGCTGACAGCTCATG GCGGCACCAACGTAGTAGCCTCTTTCTCATGGAATGGAATGGCTTTGAAT CCTGATAACTATCTCATCTCAAAGGATGTTACAGGCGCAACGAAGGTAAA GTACTACTATGCAGTCAACGACGGTTTTCCCGGGGATCACTATGCGGTGA TGATCTCCAAGACGGGCACGAACGCCGGAGACTTCACGGTCGTTTTCGAA GAAACGCCTAACGGAATAAATAAGGGCGGAGCAAGATTCGGTCTTTCCAC GGAAGCCAATGGCGCCAAACCTCAAAGTGTATGGATCGAGCGTACGGTAG ATTTGCCTGCGGGCACGAAGTATGTTGCTTTCCGTCACTACAATTGCTCG GATTTGAACTACATTCTTTTGGATGATATTCAGTTCACCATGGGTGGCAG CCCCACCCCGACCGATTATACCTACACGGTGTATCGTGATGGTACGAAGA TCAAGGAAGGTTTGACCGAAACGACCTTCGAAGAAGACGGCGTAGCTACG GGCAATCATGAGTATTGCGTGGAAGTGAAGTACACAGCCGGCGTATCTCC GAAAGAGTGCGTAAACGTAACTATTAATCCGACACAGTTCAATCCTGTAC AGAACCTGACGGCAGAACAAGCTCCTAACAGCATGGATGCAATCCTTAAA TGGAATGCACCGGCATCTAAGCGTGCGGAAGTTCTGAACGAAGACTTCGA AAATGGTATTCCTGCCTCATGGAAGACGATCGATGCAGACGGTGACGGCA ACAATTGGACGACGACCCCTCCTCCCGGAGGCTCCTCTTTTGCAGGTCAC AACAGTGCGATCTGTGTCTCTTCGGCTTCTTATATCAACTTTGAAGGTCC TCAGAACCCTGATAACTATCTGGTTACACCGGAGCTTTCTCTTCCTGGCG GAGGAACGCTTACTTTCTGGGTATGTGCACAAGATGCCAATTATGCATCA GAGCACTATGCCGTGTATGCATCTTCTACGGGTAACGACGCTTCCAACTT CGCCAACGCTTTGTTGGAAGAAGTGCTGACGGCCAAGACAGTTGTTACGG CACCGGAAGCCATTCGTGGTACTCGTGTTCAGGGCACCTGGTATCAAAAG ACGGTACAGTTGCCTGCGGGTACTAAGTATGTTGCCTTCCGTCACTTCGG CTGTACGGACTTCTTCTGGATCAACCTTGATGATGTTGTAATCACTTCAG GGAACGCTCCGTCTTACACCTATACGATCTATCGTAATAATACACAGATA GCATCAGGCGTAACGGAGACTACTTACCGAGATCCGGACTTGGCTACCGG TTTTTACACGTACGGTGTTAAGGTTGTTTACCCGAACGGAGAATCAGCTA TCGAAACTGCTACGTTGAATATCACTTCGTTGGCAGACGTAACGGCTCAG AAGCCTTACACGCTGACAGTTGTAGGAAAGACGATCACGGTAACTTGCCA AGGCGAAGCTATGATCTACGACATGAACGGTCGTCGTCTGGCAGCGGGTC GCAACACGGTTGTTTACACGGCTCAGGGCGGCCACTATGCAGTCATGGTT GTCGTTGACGGCAAGTCCTACGTAGAGAAACTCGCTGTAAAG Los Alamos National Laboratory • Est 1943 Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy

`Feature Type`	`Start`	`Stop`
`cleavable signal`	`1`	`24`
`non-globular`	`455`	`557`
`non-globular`	`859`	`998`
`non-globular`	`1311`	`1450`