LANL Gene ID: PG1865
GenBank Locus Tag: PG2132
DNA Molecule Name:
1
GenBank ID:
34541709
Gene Name:
fimA
Definition:
major fimbrillin A
Cellular Location:
Extracellular, Outer membrane [Evidence]
Gene Start:
2237840
Gene Stop:
2239003
Gene Length:
1164
Molecular Weight*:
41234
pI*:
5.10
Net Charge*:
-6.26
EC:
Functional Class:
Cell envelope; Surface structures
Gene Ontology:
Molecular function
GO:0005198 structural molecule activity
Pathway: pathway table
Primary Evidence:
See Fimbrillins
Miura M, Hamachi T, Fujise O, Maeda K.
The prevalence and pathogenic differences of Porphyromonas gingivalis fimA genotypes in patients with aggressive periodontitis.
J Periodontal Res. 2005 Apr;40(2):147-52.
PMID: 15733149
Zhang Y, Wang T, Chen W, Yilmaz O, Park Y, Jung IY, Hackett M, Lamont RJ.
Differential protein expression by Porphyromonas gingivalis in response to secreted epithelial cell components.
Proteomics. 2005 Jan;5(1):198-211.
PMID: 15619293
Nishikawa K, Yoshimura F, Duncan MJ.
A regulation cascade controls expression of Porphyromonas gingivalis fimbriae via the FimR response regulator.
Mol Microbiol. 2004 Oct;54(2):546-60.
PMID: 15469523
Missailidis CG, Umeda JE, Ota-Tsuzuki C, Anzai D, Mayer MP.
Distribution of fimA genotypes of Porphyromonas gingivalis in subjects with various periodontal conditions.
Oral Microbiol Immunol. 2004 Aug;19(4):224-9.
PMID: 15209991
Xie H, Kozlova N, Lamont RJ.
Porphyromonas gingivalis genes involved in fimA regulation.
Infect Immun. 2004 Feb;72(2):651-8.
PMID: 14742505
Lamont RJ, Jenkinson HF.
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis.
Microbiol Mol Biol Rev. 1998 Dec;62(4):1244-63.
PMID: 9841671
Secondary Evidence:
Wu H, Fives-Taylor PM.
Molecular strategies for fimbrial expression and assembly.
Crit Rev Oral Biol Med. 2001;12(2):101-15.
PMID: 11345521
Missailidis CG, Umeda JE, Ota-Tsuzuki C, Anzai D, Mayer MP.
Distribution of fimA genotypes of Porphyromonas gingivalis in subjects with various periodontal conditions.
Oral Microbiol Immunol. 2004 Aug;19(4):224-9.
PMID: 15209991
Comment:
From Genbank: [gi:38605635]
Fimbrillin is the structural subunit of the fimbriae,that are filamentous appendages on the cell surface. Fimbriae of P.gingivalis are recognized as a major virulence factor as they mediate cell adhesion and play an important role in invasion of periodontal tissues. Six genotypes have been recognized (Missailidis et al., 2004); the encosed sequence appears to best represent the type V precursor.
TIGR ID: PG2132
Human Oral Microbiome Database:
View in HOMD Genome Viewer
Blast Summary: PSI-Blast Search
This sequence corresponds to 34398027 in Genbank.
Top Blast Hits: Updated monthly
Click here to view the entire PsiBlast results.
InterPro Summary: InterProScan
| InterPro IPR008110 Family 
|
| |||||||||||||
| noIPR unintegrated |
| |||||||||||||
![[41-388]T 0 PD008717 FIMA_PORGI_P59914;](http://www.ebi.ac.uk/InterProScan/images/D.gif){kind=small}
![[64-80]T 8.9e-40 PR01737 FIMBRILLIN](http://www.ebi.ac.uk/InterProScan/images/F.gif){kind=small}
![[37-388]T 6.8e-274 PF06321 P_gingi_FimA](http://www.ebi.ac.uk/InterProScan/images/H.gif){kind=small}
![[1-19]T 7.000 PS51257 PROKAR_LIPOPROTEIN](http://www.ebi.ac.uk/InterProScan/images/M.gif){kind=small}
![[1-19]? NA signalp signal-peptide](http://www.ebi.ac.uk/InterProScan/images/S.gif){kind=small}
COGS Summary: COGS Search
No hit to the COGs database.
Blocks Summary: Blocks Search
No significant hit to the Blocks database.
ProDom Summary: Protein Domain Search
Residues 1-36 are 91% similar to a (FIMBRIAL PROTEIN PRECURSOR FIMBRILIN) protein domain (PD133381 which is seen in FMA_PORGI.
Paralogs: Local Blast Search
No paralogs found in P. gingivalis.
Pfam Summary: Pfam Search
Residues 37 to 388 (E-value = 5.9e-274) place PG1865 in the P_gingi_FimA family which is described as Porphyromonas gingivalis major fimbrial subunit protein (FimA) (PF06321)
Structural Feature(s):
| Feature Type | Start | Stop |
| may be a lipoprotein | ||
| gram negative signal |
Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).
Gene Protein Sequence:
MKKTKFFLLGLAALAMTACNKDNEAEPVVETNATVSFIIKSGESRAVGDD
LTDAKITKLTAMVYAGQVQEGIKTVEEDGGVLKVEGIPCKSGANRVLVVV
ANHNYELTGKSLNEVEALTTSLTAENQNAKNLIMTGKSAAFTIKPGSNHY
GYPGGTASDNLVSAGTPLAVTRVHAGISFAGVEVNMATQYQNYYSFKPAD
AKIAALVAKKDSKIFGNSLVSNTNAYLYGVQTPAGLYTPDAAGETYELEA
SLNTNYAVGAGFYVLESKYDASNELRPTILCIYGKLLDKDGNPLTEPALT
DAINAGFCDGDGTTYYPVLVNYDGNGYIYSGAITQGQNKIVRNNHYKISL
NITGPGTNTPENPQPVQANLNVTCQVTPWVVVNQAATW
Gene Nucleotide Sequence: Sequence Viewer
ATGAAAAAAACAAAGTTTTTCTTGTTGGGACTTGCTGCTCTTGCTATGAC
AGCTTGTAACAAAGACAACGAGGCAGAACCCGTTGTAGAAACTAACGCTA
CTGTTAGTTTCATAATTAAGAGCGGTGAGAGCCGCGCTGTAGGCGATGAC
CTTACAGATGCTAAGATCACAAAGCTCACCGCCATGGTCTATGCAGGTCA
AGTTCAAGAAGGTATTAAGACAGTGGAAGAGGACGGCGGAGTCCTTAAAG
TAGAAGGAATTCCGTGTAAATCTGGAGCCAACCGTGTCCTCGTCGTTGTA
GCCAATCACAATTATGAGCTTACCGGTAAAAGTTTGAATGAGGTTGAGGC
CTTGACGACTTCTTTGACAGCTGAAAACCAAAATGCCAAAAACTTGATCA
TGACAGGTAAGTCAGCAGCTTTTACAATCAAACCGGGCTCCAACCACTAT
GGCTATCCTGGTGGGACTGCATCCGACAACCTTGTTTCTGCTGGAACTCC
TCTTGCCGTTACTCGCGTGCATGCCGGTATCTCATTCGCAGGAGTAGAGG
TAAATATGGCTACACAGTATCAAAACTACTATTCTTTTAAACCAGCTGAC
GCTAAAATCGCAGCCCTTGTCGCAAAGAAAGATTCTAAGATTTTCGGCAA
TTCTTTGGTCTCAAACACTAATGCATATTTGTATGGAGTCCAAACGCCTG
CCGGTCTTTACACTCCGGATGCTGCAGGAGAAACATACGAATTGGAGGCG
TCTTTGAATACGAATTATGCTGTAGGTGCCGGCTTCTATGTGCTGGAAAG
TAAATATGATGCAAGCAACGAGCTTCGTCCGACGATCCTTTGTATCTATG
GAAAGCTGCTCGATAAGGACGGCAACCCTCTCACGGAACCAGCCTTGACG
GATGCTATAAATGCCGGATTCTGCGACGGAGATGGCACGACTTACTATCC
GGTATTGGTGAACTATGATGGCAATGGCTACATCTATTCAGGTGCTATTA
CCCAAGGACAAAACAAAATCGTTCGCAACAACCACTACAAGATTTCGCTG
AACATCACCGGCCCCGGTACGAATACTCCTGAAAATCCTCAACCGGTACA
AGCCAACCTGAATGTTACTTGCCAAGTTACACCTTGGGTTGTTGTTAATC
AGGCTGCTACTTGG