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Porphyromonas gingivalis Search Results

Record: 1 of 1  
MiniMap IGR1654 IGR1652 IGR1653 IGR1649 IGR1651 IGR1650 def, - PG1925 ISPg1, - PG1919 ISPg4,tnp, - PG1920 PG1923 PG1924 PG1921 PG25, - PG1922 PG1918 def, - PG1925 ISPg1, - PG1919 ISPg4,tnp, - PG1920 PG1923 PG1924 PG1921 PG25, - PG1922 PG1918 Type: IS element, Name: ISPg1 - 2 Type: IS element, Name: ISPg1 fragment - 3 Type: IS element, Name: ISPg4 - 7 def, - PG1925 ISPg1, - PG1919 ISPg4,tnp, - PG1920 PG1923 PG1924 PG1921 PG25, - PG1922 PG1918


LANL Gene ID: PG1922

GenBank Locus Tag: PG2198

DNA Molecule Name:
1  

Genomic Island ID:
29

GenBank ID:
5052029

 Gene Name:
PG25  

 Definition:
hemagglutinin/gingipain-related protein

 Cellular Location:
Cytoplasm, Periplasm, Extracellular [Evidence]

 Gene Start:
2303756

Gene Stop:
2304634

Gene Length:
879

Molecular Weight*:
32259

pI*:
4.30

Net Charge*:
-21.91

EC:
 

 Functional Class:
Protein fate; Degradation of proteins, peptides and glycopeptides  

 Gene Ontology:

Pathway: pathway table

 Primary Evidence:
See href="http://linker.lanl.gov/readonly/oragen/bacteria/pgin/hemagglutinin/summ_hemag.htm">Proteases/Hemagglutinin Analysis


Ross,B., Barr,I., Patterson,M., Agius,C., Rothel,L., Margetts,M.,
Hocking,D. and Webb,E., P. gingivalis polypeptides and nucleic acids, Patent: Australia AU 98/01023-PCT 10-DEC-1998

 Comment:
TIGR ID: PG2198

 Proteomic Data: Proteomic Data Search
TIGR Annotationimmunoreactive 32 kDa antigen PG25, GroupT (unknown function)
ORF #PG-PP/PG-PPC1PG-PP/PG-PPC2
Spectral CountPeptide IntensitySpectral CountPeptide Intensity
ProqValProqValProqValProqVal
TIGRPG2198-1.640.00852.390.0381.450.0632.390.038
LANLPG19220.325.262.7337.28
ConsensusSP1IP1SP2IP2

Human Oral Microbiome Database:
View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
PG1922 has been previously sequenced in P.gingivalis, strain W50,
and as AAD38410 in GenBank submitted by Ross,B., Barr,I., Patterson,M., Agius,C., Rothel,L., Margetts,M., Hocking,D. and Webb,E.

 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|5052029|gb|AAD38410.1|AF155351_1  immunoreactive 32 kD an...   545   e-154
 gi|1890077|gb|AAB49691.1|  hemagglutinin [Porphyromonas ging...    97   1e-18
 gi|1536824|dbj|BAA11870.1|  Lys-gingipain [Porphyromonas gin...    97   1e-18
 gi|1314751|gb|AAA99810.1|  Lys-gingipain                           97   1e-18
 gi|2738803|gb|AAC26523.1|  lysine specific cysteine protease...    96   3e-18
 gi|3869077|dbj|BAA34341.1|  130k-HMGD [Porphyromonas gingiva...    96   3e-18
 gi|1314326|gb|AAB06565.1|  porphypain                              96   3e-18
 gi|2182812|gb|AAB60809.1|  lysine-specific cysteine proteina...    96   3e-18
 gi|34541613|ref|NP_906092.1|  hemagglutinin protein HagE [Po...    96   4e-18
 gi|1813996|emb|CAA57997.1|  protease precursor [Porphyromona...    96   4e-18


InterPro Summary:  InterProScan

noIPR
unintegrated
unintegrated
signalp [1-28]? NA signalp signal-peptide signal-peptide
tmhmm [10-28]? NA tmhmm transmembrane_regions transmembrane_regions


COGS Summary:  COGS Search
No hit to the COGs database.
Blocks Summary:  Blocks Search
***** PF01364 (Peptidase family C25) with a combined E-value of 2.6e-14.
    PF01364F    197-250
    PF01364G    251-289


 ProDom Summary:  Protein Domain Search
Residues 68-130 are 58% similar to a (PROTEASE PRECURSOR SIGNAL THIOL HEMAGGLUTININ REPEAT) protein domain (PD002028 which is seen in Q51817_PORGI.

Residues 215-293 are 43% similar to a (PROTEASE PRECURSOR THIOL SIGNAL) protein domain (PD004371 which is seen in HAGA_PORGI.

Residues 98-253 are 30% similar to a (PROTEIN PRECURSOR SIGNAL SURFACE C ALPHA-ANTIGEN ANTIGEN) protein domain (PD011934 which is seen in Q9Z4N7_ENTFA.

Residues 77-122 are 65% similar to a (PROTEASE THIOL REPEAT PRECURSOR) protein domain (PD013956 which is seen in Q51839_PORGI.


Paralogs:  Local Blast Search
There are four domains in PG1922 which show strong similarity to domains in other related hemagglutinins and gingipains. These domains are: 68-152, 77-160, 152-222, and 168-234. They show strong similarity to one or many domains in:
PG1605 porphypain polyprotein; lys-X proteinase/hemagglutinin,
PG1768 arginine-specific cysteine proteinase: gingipain,
PG1602 hemagglutinin/adhesin precursor; hagA,
PG1606 hemagglutinin-related protein,
PG1164 tonB linked outer membrane receptor,
PG0461 arginine-specific cysteine proteinase: gingipain R2.


Pfam Summary:  Pfam Search
No significant hits to the Pfam 11.0 database

 Structural Feature(s):
Feature Type  Start  Stop
gram negative signal  
1  
28
cleavable signal  
1  
28
non-globular  
35  
106

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
MKQNYFKRVCSLLWLVLPMLIMPLEVAAQEIIPNEEVLESLTFVAPVEET
DAIEAEVEALQEIVATEEIAEQAVRSYTYTVYRDGVKIASGLTEPTFLDE
DVPAGEHTYCVEVQYQGGVSDKVCVDVEVKDFKPVTNLTGTASNDEVSLD
WDGVEEKAEEPASDKAVSYNVYKNGTLIGNTAETHYVETGVANGTYIYEV
EVKYPDGVSPKVAVTVTVTNSSLSNVDGQAPYTLRVEGKKIIAEAHGMIT
LYDINGRTVAVAPNRLEYMAQTGFYAVRFDVGNKHHVSKIQVR

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAACAGAACTACTTCAAAAGAGTCTGCTCACTGCTTTGGCTGGTTTT
ACCCATGCTTATTATGCCATTGGAAGTAGCAGCTCAAGAGATTATTCCGA
ACGAAGAGGTGTTGGAATCATTGACTTTCGTTGCACCGGTTGAGGAGACA
GACGCAATAGAGGCAGAGGTAGAAGCTCTGCAGGAGATAGTCGCTACTGA
GGAGATTGCGGAGCAGGCTGTTCGTTCTTATACCTACACGGTCTATCGTG
ATGGCGTGAAGATTGCTTCAGGATTGACTGAGCCCACTTTTCTCGATGAA
GATGTTCCTGCCGGCGAACATACCTACTGCGTAGAAGTACAGTATCAGGG
AGGCGTATCCGACAAAGTATGCGTGGACGTAGAGGTGAAGGACTTCAAAC
CGGTTACCAATCTCACCGGAACTGCTTCCAATGACGAAGTTTCTTTGGAC
TGGGACGGTGTGGAAGAGAAAGCTGAAGAGCCGGCAAGTGATAAAGCAGT
CAGCTACAACGTCTACAAGAATGGAACCTTGATCGGTAATACAGCTGAAA
CTCATTATGTGGAGACCGGTGTAGCCAATGGTACATACATCTACGAAGTG
GAAGTAAAGTATCCTGACGGTGTATCTCCGAAGGTGGCTGTAACCGTGAC
CGTGACCAACAGCTCATTGAGCAATGTAGATGGACAGGCTCCTTACACAT
TGCGAGTAGAAGGCAAGAAGATTATTGCGGAAGCCCATGGTATGATCACG
CTCTACGACATCAACGGACGTACCGTGGCCGTAGCCCCGAATCGATTGGA
ATACATGGCGCAAACCGGTTTCTATGCAGTGCGCTTCGATGTGGGGAATA
AACACCATGTATCGAAAATACAAGTAAGA

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