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Protein-Protein Interactions Table for Human herpesvirus 1
| Gene ID | Name(s) | Substrate | Viral? | Description of Interaction |
| HHVONE001 | gamma34.5 | protein phosphatase 1 | no | binds and redirects protein phosphatase 1 to dephosphorylate the alpha subunit of translation initation factor 2 (eIF-2alpha) |
| HHVONE001 | gamma34.5 | US11 | yes | binds US11 through an RNase sensitive bond |
| HHVONE002 | alpha0 RL2 | ICP4(alpha4) | yes | interacts with ICP4 |
| HHVONE002 | alpha0 RL2 | EF-1delta | no | binds eukaryotic elongation factor 1delta |
| HHVONE002 | alpha0 RL2 | cyclin D3 | no | binds and stabilizes cyclin D3 |
| HHVONE002 | alpha0 RL2 | CENP-C | no | binds and destabilizes CENP-C |
| HHVONE002 | alpha0 RL2 | PML | no | binds PML and removes SUMO-1 conjugates |
| HHVONE002 | alpha0 RL2 | Sp100 | no | binds Sp100, ND10 associated, and removes SUMO-1 conjugates |
| HHVONE002 | alpha0 RL2 | DNA-PK | no | binds and destabilizes DNA-PK |
| HHVONE011 | UL10 | gB | yes | interacts with gB |
| HHVONE012 | UL9 | DNA | yes | binds origin of DNA synthesis |
| HHVONE015 | UL13 | ICP0 (alpha0) | yes | phosphorylation |
| HHVONE015 | UL13 | ICP22 (alpha22) | yes | phosphorylation |
| HHVONE015 | UL13 | US1.5 | yes | phosphorylation |
| HHVONE015 | UL13 | vhs (UL41) | yes | phosphorylation |
| HHVONE015 | UL13 | gE (US8) | yes | phosphorylation |
| HHVONE015 | UL13 | VP22 (UL49) | yes | phosphorylation |
| HHVONE015 | UL13 | eukaryotic EF-1delta | no | phosphorylation |
| HHVONE021 | UL19 | ICP35(UL26.5) | yes | interacts with ICP35 |
| HHVONE026 | UL23 | wide diversity of nucleoside analogues | no | phosphorylation |
| HHVONE028 | UL26 | UL26.5 | yes | cleaves between Ala304 - Ser305 |
| HHVONE028 | UL26 | UL26 | yes | cleaves between Ala247 - Ser248 |
| HHVONE030 | UL27 | glycosoaminoglycan (GAG) | no | interacts with GAGs on cell membrane surface |
| HHVONE031 | UL28 | UL15 | yes | interacts allowing UL28 to enter nuclei |
| HHVONE032 | UL29 | ssDNA | yes | binds single-stranded DNA |
| HHVONE033 | UL30 | ssDNA | yes | binds single-stranded DNA |
| HHVONE034 | UL31 | UL34 | yes | |
| HHVONE037 | UL34 | UL31 | yes | |
| HHVONE037 | UL34 | ICP5(UL19) | yes | |
| HHVONE037 | UL34 | dynein IC-1a | no | |
| HHVONE041 | UL38 | DNA | yes | binds DNA |
| HHVONE042 | UL39 | deoxyribonucleoside diphosphate | no | catalyses ribonucleoside diphosphate synthesis |
| HHVONE042 | UL39 | UL39 | yes | autophosphorylation |
| HHVONE043 | UL40 | deoxyribonucleoside diphosphate | no | catalyses ribonucleoside diphosphate synthesis |
| HHVONE044 | UL41 vhs | RNA | no | endoribonucleolytic cleavage of cellular and viral mRNAs |
| HHVONE045 | UL42 | dsDNA | no | binds double-stranded DNA |
| HHVONE047 | UL44 | complement component C3 | no | |
| HHVONE051 | UL48 | DNA | no | binds DNA at TAATGARAT (R = purine) |
| HHVONE054 | UL50 | dUTP | no | hydrolyzes dUTP to dUMP and pyrophosphate |
| HHVONE056 | UL52 | DNA | no | binds DNA |
| HHVONE061 | alpha0 RL2 | ICP4(alpha4) | yes | interacts with ICP4 |
| HHVONE061 | alpha0 RL2 | EF-1delta | no | binds eukaryotic elongation factor 1delta |
| HHVONE061 | alpha0 RL2 | cyclin D3 | no | binds and stabilizes cyclin D3 |
| HHVONE061 | alpha0 RL2 | CENP-C | no | binds and destabilizes CENP-C |
| HHVONE061 | alpha0 RL2 | PML | no | binds PML and removes SUMO-1 conjugates |
| HHVONE061 | alpha0 RL2 | Sp100 | no | binds Sp100, ND10 associated, and removes SUMO-1 conjugates |
| HHVONE061 | alpha0 RL2 | DNA-PK | no | binds and destabilizes DNA-PK |
| HHVONE062 | gamma34.5 | protein phosphatase 1 | no | binds and redirects protein phosphatase 1 to dephosphorylate the alpha subunit of translation initation factor 2 (eIF-2alpha) |
| HHVONE062 | gamma34.5 | US11 | yes | binds US11 through an RNase sensitive bond |
| HHVONE063 | alpha4 RS1 | DNA | no | binds with high affinity to the sequence -ATCGTC- |
| HHVONE064 | alpha22 US1 | p78, GenBank:AF068007 | no | interacts with p78, a cell-cycle dependent protein |
| HHVONE064 | alpha22 US1 | p60 | no | interacts with carboxy-terminal 40 aa of ICP22 |
| HHVONE066 | US3 | alpha22 | yes | phosphorylation |
| HHVONE066 | US3 | UL34 | yes | phosphorylation |
| HHVONE069 | US6 | HveA, cellular membrane receptor | no | binds to cell surface |
| HHVONE069 | US6 | HveC, cellular membrane receptor | no | binds to cell surface |
| HHVONE071 | US8 | cell junction components | no | |
| HHVONE075 | US11 | large subunit rRNA | no | binds rRNA |
| HHVONE076 | alpha47 US12 | TAP1/2 (transporter associated with antigen presentation) | no | inhibits peptide transport by binding TAP1/2 |
| HHVONE077 | alpha4 RS1 | DNA | no | binds with high affinity to the sequence -ATCGTC- |
| HHVONE001.1 | Orf-P | p32 | no | binds p32, a component of ASF/SF2 alternate splicing factors |
| HHVONE061.1 | Orf-P | p32 | no | binds p32, a component of ASF/SF2 alternate splicing factors |