Actinomyces species are Gram-positive, anaerobic bacteria that normally colonizes oral cavity in animals including humans. Actinomyces form the major component of oral plague and can cause opportunistic infections such as actinomycosis when invading tissues. Several other infections in which Actinomyces can play a role are: gingivitis, mild periodontitis and root surface tooth decay. However, it is not known to be the major player in causing severe periodontal disease. The complete genome of Actinomyces naeslundii MG1 was kindly provided prior to publication by Dr. Garry Myers. The sequencing was performed at J. Craig Venter Institute (JCVI) under the auspices of the NIDCR/NIH.

Actinomyces naeslundii MG1 genome consists of 3.04 Mbp and with G+C content of 68.5%. 87.6% of genome are known to be coding sequences. There are about 2800 protein coding genes. Currently, manual curation of coding regions and functional assignments have been performed. Machine-predicted coding regions were manually checked for errors in gene predictions and corrected where possible. Automated transporter analysis was done to identify potential transporters and manually checked to improve accuracy.

Insertion sequence analysis and cellular location predictions were also carried out. Please scroll down the left navigation menu to visit the analysis pages for Insertion Sequences and Cellular Location predictions. Metabolic pathway prediction is also done and results can be seen by following the link provide below. Please note that some analyses are not yet available and we removed links to these pages. Nine references drawn from the molecular subset of Medline were included from years 2004-2006. Please let us know of any pertinent reference that may have been omitted.

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