Plasma membrane organization of the 4 protein domains of the main types of ABC transporters encountered in Fusobacterium nucleatum and gene organization.

Domain Type

NBD protein

MSD protein

SBP Protein

Function

NBD1

NBD2

MSD1

MSD2

SBP1

SBP2

1

FN0307

FN0310

FN0306

FN0309

FN0305

FN0308

iron

1

FN0399

FN0400

FN0397

FN0398

FN0396

dipeptide

1

FN1109

FN1110

FN1112

FN1113

FN1111

dipeptide/oligopeptide

1

FN1362

FN1363

FN1360

FN1361

FN1359

dipeptide

1

FN1428

FN1429

FN1430

FN1431

FN1432

branched-chain amino acid

1

FN1500

FN1501

FN1502

FN1503

FN1504

nickel

1

FN1524

FN1525

FN1521

FN1522

FN1523

nickel/dipeptide

1

FN1648

FN1649

FN1650

FN1651

FN1652

oligopeptide

2

FN0195

FN0193

FN0194

FN0192

dipeptide

2

FN0669

FN0670

FN0671

FN0668

zinc/manganese

2

FN0880

FN0879

FN0881

multidrug transport (?)

2

FN1797

FN1798

FN1799

spermidine/putrescine

2

FN1898

FN1896

FN1897

branched-chain amino acid(?)

2

FN1352

FN1353

FN1354

(?)

3

FN0376

FN0377

FN0377

FN0375

iron III

3

FN0660

FN0659

FN0658

(?)

3

FN0801

FN0802

FN0800

glutamine

3

FN0235

FN0237

FN0236

taurine/hydroxymethylpyrimidine

3

FN0302

FN0301

FN0301

FN0300

iron (III)

3

FN0582

FN0581

(?)

3

FN0598

FN0598

multidrug/protein/lipid(?)

3

FN0827

FN0828

(?)

3

FN0882

FN0884

FN0885

iron (III)

3

FN0770

FN0769

FN0769

FN0767

iron (III)

6

FN1080

FN1080

multidrug/protein/lipid (?)

6

FN1136

FN1137

FN1137

FN1135

phosphate

7

FN1166

FN1167

FN1167

FN1165

galactose

8

FN1348

FN1349

(?)

8

FN1811

FN1810

FN1810

FN1809

FN1812

manganese

8

FN1968

FN1969

FN1969

FN1970

ferrichrome

8

FN2008

FN2009

FN2009

glycine betaine/carnitine/choline

8

FN2079

FN2080

FN2080

FN2081

ribose/xylose/arabinose/galactoside (?)

8

FN0614

FN0615

FN0614

FN0615

multidrug/protein/lipid(?)

8

FN1819

FN1820

FN1819

FN1820

multidrug/protein/lipid(?)

8

FN2004

FN2005

FN2006

cobalt


Plasma membrane organization of the four protein domains of the main types of ABC transporters encountered in Fusobacterium nucleatum. The membrane-spanning domains (MSDs) and the two nucleotide-binding domains (NBDs) are depicted by ovals and triangles, respectively. When fused, domains are linked together using a large connecting area.