Fusobacterium nucleatum is a Gram-negative anaerobic bacteria that is part of the oral bacterial community and dominant member of dental plaque biofilms. F. nucleatum is also known to contribute to tooth decay and gingivitis. Fusobacterium nucleatum subsp. polymorphum ATCC 10953 is a phenotypically well-characterized strain available and taxonomic studies have shown that it forms a separate phylogenetic brach from previously sequenced strains of F. nucleatum¹. The complete genome sequence of Fusobacterium nucleatum subsp. polymorphum ATCC 10953 was done by The Human Genome Sequencing Center, Baylor College of Medicine. The paper describing the complete genome is by Karpathy et al, 2007, "Genome Sequence of Fusobacterium nucleatum Subspecies Polymorphum — a Genetically Tractable Fusobacterium". PLoS ONE. 2(7):e659.

The genome of F. nucleatum subsp. polymorphum ATCC 10953 contains a chromosome of approximately 2.4 Mbp and a plasmid (pFN3) of 11.9 Kbp. G+C content of the chromosome is about 27% and there are 2361 proteins are encoded in the genome. Each gene record is identified by a gene id, for example: FNP_0001 to FNP_2433. Annotated genome of F. nucleatum polymorphum was kindly provided by Dr. Sarah Highlander and Dr. George Weinstock from Baylor College of Medicine and we have manually checked and curated the annotation. The Genome Annotation ToolKit (ATK) was use to obtain evidence for determining final gene definitions.

Transporter analysis was automatically done using the TransAAP program to aid in identifying all potential transporters and manually compared with final annotation definitions to check accuracy of predictions. Several references pertaining to Fusobacterium nucleatum subsp. polymorphum that might be of interest to researchers in oral biology are summarized here. Please let us know if we have missed any relevent references.

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