Human herpesvirus 1

Human herpesvirus 1 (HSV-1)
Gene Image Map
Human herpesvirus 1, strain 17, commonly called herpes simplex virus 1, was sequenced by the McGeoch laboratory and published in a series of papers from 1985-1988. These are included in a comprehensive set of references from Medline (1980-6/2000), HSV-1 References. Human herpesvirus 1 is a member of the Herpesviridae family. General properties are available here, Herpesviridae Properties. Interesting genome information and properties specific to HSV-1 are available here, HSV-1 Properties.

An overview map of the genome and information summary is available through the Gene Image Map. The newest version of this map clearly depicts coterminal and overlapping genes, genes coding on opposite strands and repeats, all of which are common in the tightly packed genomes of herpesviruses. A double-stranded interactive visualization tool, called BugBrowser , is now available.

The core information in this database is the table of annotated records, one for each of 90 genes. Each gene record is identified by a gene id, HHVONE001-HHVONE077 (some with extensions to total 90). Seventy-eight of the genes are unique and six (gamma34.5, Orf-P, Orf-O, alpha0, alpha4, and the LAT) appear twice in the genome, once in each copy of the inverted repeats. Simple summaries of specific information are available below in the Predefined Database Searches and contain links to the complete gene record.

The power of a relational database is demonstrated in the ability to search it's information. We provide five search tools, each with different characteristics. The Basic Search allows a simple query of many fields for a text term. The Intermediate Search allows the user to search specific tables, to search a range of molecular weights or isoelectric points and to search the protein or nucleotide sequences for simple patterns. The Protein Motif Search allows searching protein sequences for sophisticated amino acid patterns. Repeat Search queries the repeat table for previously located nucleotide repeats.

User Defined Database Searches
Basic Search
Intermediate Search
Sequence Search
Protein Motif Search
Repeat Search

Predefined Database Searches
Definition Table
Functional Classes Table
EC Table
PDB Table
Essential Genes Table
Posttranslational Modifications Table
Protein-Protein Interactions Table
Repeat Tables
           Tandem
           Terminal
           Inverted
           All
Cellular Homolog Table
Visualization
Gene Image Map
Genome Visualization Tool - BugBrowser

Los Alamos National Laboratory • Est 1943