Porphyromonas gingivalis

Porphyromonas gingivalis ATCC 33277
Gene Image Map Porphyromonas gingivalis is a gram-negative anaerobic bacterium, which is often found in deep periodontal pockets of humans, is asaccharolytic and highly proteolytic. Porphyromonas gingivalis produces a broad array of potential virulence factors involved in tissue colonization and destruction as well as host defense perturbation. Porphyromonas gingivalis strains have been classified into virulent and less-virulent strains by mouse subcutaneous soft tissue abscess model analysis. P. gingivalis ATCC 33277 classified as a less-virulent strain is the type strain of P. gingivalis and has been widely used for characterization of pathophysiological features of the microorganism. The complete genome sequence of P. gingivalis ATCC 33277 was done by Hattori Laboratory at University of Tokyo. The paper describing the complete genome is by Naito M, et al. 2008 “Determination of the Genome Sequence of Porphyromonas gingivalis Strain ATCC 33277 and Genomic Comparison with Strain W83 Revealed Extensive Genome Rearrangements in P. gingivalis (DNA Research, 2008).

The genome of P. gingivalis ATCC 33277 contains a chromosome of approximately 2.35 Mbp. G+C content of the chromosome is about 48 % GC and there are 2090 protein-coding sequences (CDSs), 4 RNA operons, and 53 tRNA genes in the ATCC 33277 genome. By genomic comparison with the virulent strain W83, 461 ATCC 33277-specific and 415 W83-specific CDSs were identified. Annotated genome of P. gingivalis ATCC 33277 was initially provided by Hattori Laboratory and we are manually checking and curating the annotation. The Genome Annotation ToolKit (ATK) was use to obtain evidence for determining final gene definitions. Several references pertaining to P. gingivalis ATCC 33277 that might be of interest to researchers in oral biology are summarized here. Please let us know if we have missed any relevant references.

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Los Alamos National Laboratory • Est 1943