Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a Gram-positive streptococcus responsible for the leading cause of neonatal meningitis, sepsis, and pneumonia in newborn babies and also cause serious infections in adults who are immunocompromised. They can also colonize human skin and mucous membranes without causing any symptoms associated with infection. Streptococcus agalactiae 2603V/R is a serotype V clinical isolate which is the most common serotype associated with GBS-infected non-pregnant adults.

Streptococcus agalactiae 2603V/R has a genome of approximately 2.16 Mb encoding about 2200 proteins and a GC content of 35.6%. The key publication reporting this work is by Tettelin et al. "Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae". Proc Natl Acad Sci USA 2002, 99(19):12391-12396. Streptococcus agalactiae 2603V/R was sequenced by The Institute for Genomic Research (TIGR) and funded by NIAID. The core information for the database is a table of 2177 predicted open reading frams (ORFs). Each gene record is identified by a gene id, for example: SAG0001 to SAG2175. Record designations have some discontinuities and some IDs have number suffix of 1, 2, 3 etc. We did not annotate this genome but use it as one of the organisms for comparative genomic analysis of oral streptococci.

Basic summaries of specific information are available below in the Predefined Database Searches which contain links to the complete gene record. For a general perspective of the genome, we recommend you go to the Gene Image Map and browse blocks of coordinates. Caution: The entire 2.16 Mb genome can be viewed at one time, however this large file can cause some machines to freeze. Browsing and searching are also facilitated by the [Functional Classes], [EC Table], and [Biochemical Pathways] summaries. For precise inquiries on the other hand, start with the search capabilities and their associated tables. Please note that some analyses are not yet available and we removed links to these pages. We encourage anyone with questions or suggestions to contact us at oralgen@lanl.gov

User Defined Database Searches
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Intermediate Search
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Sequence Search
Protein Motif Search
Repeat Search
DNA/RNA Motif Search

Predefined Database Searches
Genomic Island Table
Secondary Structure Table
Definition Table
Functional Classes Table
EC Table
PDB Table
Metabolic Pathways
Repeat Table
Codon Usage Table

Specialized Analysis
Phylotenetic Fingerprints
ABC Transporters
Base Composition Analysis

RNA Tables and Maps
Transfer RNA Table
Ribosomal RNA Table
Transfer & Ribosomal RNA Map