Streptococcus mitis is a Gram-positive commensal bacteria commonly found in the human mouth, throat and nasopharynx. Although not known to be pathogenic Streptococcus mitis is phylogenetically related to pathogenic streptococci and thus we included it in our group of organisms for comparative genomic analysis. Strain NCTC 12261 of Streptococcus mitis is the type strain of this species has a genome of approximately 1.84 Mb and a GC content of 40%. Sequencing of Streptococcus mitis NCTC 12261 is not yet completed and analysis we present here is based on draft genome sequence available. For questions regarding the sequencing and the strain, please contact Dr. Hervé Tettelin.

Streptococcus mitis NCTC 12261 was sequenced by The Institute for Genomic Research (TIGR) and funded by NIDCR. The core information for the database is a table of 2149 predicted open reading frams (ORFs). Each gene record is identified by a gene id, for example: SMT0001 to SMT2149. Record designations have some discontinuities and some IDs have number suffix of 1, 2, 3 etc. We did not annotate this genome but use it as one of the organisms for comparative genomic analysis of oral streptococci.

Basic summaries of specific information are available below in the Predefined Database Searches which contain links to the complete gene record. For a general perspective of the genome, we recommend you go to the Gene Image Map and browse blocks of coordinates. Caution: The entire 1.84 Mb genome can be viewed at one time, however this large file can cause some machines to freeze. Browsing and searching are also facilitated by the [Functional Classes], [EC Table], and [Biochemical Pathways] summaries. For precise inquiries on the other hand, start with the search capabilities and their associated tables. We encourage anyone with questions or suggestions to contact us at oralgen@lanl.gov

User Defined Database Searches
Basic Search
Intermediate Search
Advanced Search
Sequence Search
Protein Motif Search
Repeat Search
DNA/RNA Motif Search

Predefined Database Searches
Secondary Structure Table
Definition Table
Functional Classes Table
EC Table
PDB Table
Metabolic Pathways
Codon Usage Table

Specialized Analysis
Base Composition Analysis

RNA Tables and Maps
Transfer RNA Table
Ribosomal RNA Table
Transfer & Ribosomal RNA Map