Streptococcus pneumoniae belongs to Gram-positive cocci that colonize normal human nasopharyngeal flora. Many antigenic types are present and their classification are based on the capsular antigens. Common diseases associated with Streptococcus pneumoniae are, sinusitis, acute bacterial otitis media, and conjunctivitis. Pneumonia, meningitis, and bacteremia are also known causes of Streptococcus pneumoniae.

Strain TIGR4 of Streptococcus pneumoniae is a highly virulent serotype 4 strain isolated from a 30 year old male patient in Norway. It is found to have a genome of approximately 2.16 Mb encoding approximately 2100 proteins and a GC content of 39.7%. The key publication reporting this work is Tettelin et al. "Complete genome sequence of a virulent isolate of Streptococcus pneumoniae". Science 2001, 293(5529):498-506. Streptococcus pneumoniae TIGR4 was sequenced by The Institute for Genomic Research (TIGR) and funded by NIAID and MGRI. The core information for the database is a table of 2125 predicted open reading frames. Each gene record is identified by a gene id, SP_0001-SP_2240. Record designations have some discontinuities and some IDs have number suffix of 1, 2, 3 etc. We did not annotate this genome but use it as one of the organisms for comparative genomic analysis of oral streptococci.

Basic summaries of specific information are available below in the Predefined Database Searches which contain links to the complete gene record. For a general perspective of the genome, we recommend you go to the Gene Image Map and browse blocks of coordinates. Caution: The entire 2.16 Mb genome can be viewed at one time, however this large file can cause some machines to freeze. Browsing and searching are also facilitated by the [Functional Classes], [EC Table], and [Biochemical Pathways] summaries. For precise inquiries on the other hand, start with the search capabilities and their associated tables. We encourage anyone with questions or suggestions to contact us at oralgen@lanl.gov

User Defined Database Searches
Basic Search
Intermediate Search
Advanced Search
Sequence Search
Protein Motif Search
Repeat Search
DNA/RNA Motif Search

Predefined Database Searches
Genomic Island Table
Secondary Structure Table
Definition Table
Functional Classes Table
EC Table
PDB Table
Metabolic Pathways
Repeat Table
Codon Usage Table

Specialized Analysis
Phylotenetic Fingerprints
ABC Transporters
Base Composition Analysis

RNA Tables and Maps
Transfer RNA Table
Ribosomal RNA Table
Transfer & Ribosomal RNA Map