Streptococcus thermophilus is a Gram-positive lactic acid producing bacteria that are used in production of yogurt and cheese. Although mainly used in food industry, Streptococcus thermophilus is phylogenetically related to pathogenic streptococci and has potential for virulence and we included it in our group of organisms for comparative genomic analysis. Strain CNRZ1066 of Streptococcus thermophilus was isolated from yogurt in France. It has a genome of approximately 1.80 Mb encoding about 1900 proteins and a GC content of 39.1%.

The key publication reporting this work is Bolotin et al. "Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus". Nature biotechnology 2004, 22(12):1554-1558. Streptococcus thermophilus CNRZ1066 was sequenced by Institut National de la Recherche Agronomique, France and funded by Walloon Region and FNRS. The core information for the database is a table of 1916 predicted open reading frams (ORFs). Each gene record is identified by a gene id, for example: STr0001 to STr2025. Record designations have some discontinuities and some IDs have number suffix of 1, 2, 3 etc. We did not annotate this genome but use it as one of the organisms for comparative genomic analysis of oral streptococci.

Basic summaries of specific information are available below in the Predefined Database Searches which contain links to the complete gene record. For a general perspective of the genome, we recommend you go to the Gene Image Map and browse blocks of coordinates. Caution: The entire 1.80 Mb genome can be viewed at one time, however this large file can cause some machines to freeze. Browsing and searching are also facilitated by the [Functional Classes], [EC Table], and [Biochemical Pathways] summaries. For precise inquiries on the other hand, start with the search capabilities and their associated tables. We encourage anyone with questions or suggestions to contact us at oralgen@lanl.gov

User Defined Database Searches
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Sequence Search
Protein Motif Search
Repeat Search
DNA/RNA Motif Search

Predefined Database Searches
Genomic Island Table
Secondary Structure Table
Definition Table
Functional Classes Table
EC Table
PDB Table
Metabolic Pathways
Repeat Table
Codon Usage Table

Specialized Analysis
Phylotenetic Fingerprints
ABC Transporters
Base Composition Analysis

RNA Tables and Maps
Transfer RNA Table
Ribosomal RNA Table